Document and Entity Information Statement [Table] Statement Document Type Document Annual Report Document Period End Date Document Transition Report Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line Two Entity Address, Address Line Three Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Current Reporting Status Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company ICFR Auditor Attestation Flag Entity Shell Company Entity Public Float Entity Common Stock, Shares Outstanding Entity Central Index Key Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Amendment Flag Auditor Name Auditor Location Auditor Firm ID CONSOLIDATED BALANCE SHEETS Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Available-for-sale Securities, Debt Securities, Current Marketable securities Fair Value Accounts and Other Receivables, Net, Current Accounts and other receivables Prepaid Expense and Other Assets, Current Prepaid and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Operating Lease, Right-of-Use Asset Operating lease right-of-use assets, net Intangible Assets, Net (Excluding Goodwill) Intangible assets Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Accrued Liabilities, Current Accrued expenses Accrued expenses Operating Lease, Liability, Current Current portion of operating lease liabilities Other Liabilities, Current Less current portion Current portion of long-term liabilities Liabilities, Current Total current liabilities Operating Lease, Liability, Noncurrent Long-term portion of operating lease liabilities Other Liabilities, Noncurrent Other long-term liabilities Long-term portion Liabilities Total liabilities Commitments and Contingencies. Commitments and contingent liabilities Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Convertible preferred stock, $.01 par value; 3,000,000 shares authorized; no shares issued and outstanding at December 31, 2022 and 2021 Common Stock, Value, Issued Common stock, $.001 par value; 297,000,000 shares authorized; 47,200,695 and 46,730,198 shares issued and outstanding at December 31, 2022 and 2021, respectively Additional Paid in Capital, Common Stock Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders Equity Balance, ending Balance, beginning Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Convertible Preferred Stock, Par Value (in dollars per share) Preferred Stock, Shares Authorized Convertible Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Convertible Preferred Stock, Shares Issued Preferred Stock, Shares Outstanding Convertible Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common Stock, Par Value (in dollars per share) Common Stock, Shares Authorized Common Stock, Shares Authorized Common Stock, Shares, Issued Balance (in shares) Balance (in shares) Common Stock, Shares Issued Common Stock, Shares, Outstanding Common Stock, Shares Outstanding CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Products and Services [Axis] Products and Services [Domain] Service [Member] Product development and licensing agreements Grant [Member] Contracts and grants Revenues [Abstract]. Revenues: Revenue from Contract with Customer, Excluding Assessed Tax Total revenues Revenues Costs and Expenses [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense General and administrative Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) Intangible asset impairment Non-cash impairment charge Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset Gain on fair value remeasurement of contingent consideration Gain on fair value remeasurement of contingent consideration Gain (Loss) Related to Litigation Settlement Litigation settlement related loss Costs and Expenses Total operating expenses Operating Income (Loss) Operating loss Interest and Other Income Investment and other income, net Other income Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Net loss before income tax benefit Pre-tax loss Income Tax Expense (Benefit) Income tax benefit Income tax benefit (provision) Income tax benefit Income tax (benefit) provision Non-cash income tax benefit Net Income (Loss) Available to Common Stockholders, Basic Net loss Net loss Earnings Per Share, Basic Basic and diluted net loss per common share Earnings Per Share, Diluted Basic and diluted net loss per common share Weighted Average Number of Shares Outstanding, Basic Shares used in calculating basic and diluted net loss per share Weighted Average Number of Shares Outstanding, Diluted Shares used in calculating basic and diluted net loss per share Accumulated Other Comprehensive Income Comprehensive loss: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income (loss): Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized loss on marketable securities Unrealized loss on marketable securities Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY Equity Components [Axis] Equity Component [Domain] Common Stock [Member] Common Stock Additional Paid-in Capital [Member] Additional Paid-In Capital AOCI Attributable to Parent [Member] Accumulated Other Comprehensive Income Retained Earnings [Member] Accumulated Deficit Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Stock Issued During Period, Value, Employee Stock Purchase Plan Shares issued under stock option and employee stock purchase plans Stock Issued During Period, Shares, Employee Stock Purchase Plans Shares issued under stock option and employee stock purchase plans (in shares) Issued (in shares) Shares Issued In Connection With Cantor Agreement Shares issued in connection with at the market agreement Stock Issued During Period, Shares, Other Shares issued in connection with at the market agreement (in shares) Stock Issued During Period, Shares, New Issues. Shares issued in underwritten offering, net Stock Issued During Period, Shares, New Issues Shares issued in underwritten offering, net (in shares) Common stock issued (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation CONSOLIDATED STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash flows from operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: .Depreciation, Depletion and Amortization Depreciation and amortization Depreciation and amortization expense Accretion (Amortization) of Discounts and Premiums, Investments Amortization and premium of marketable securities, net Gain (Loss) on Disposition of Property Plant Equipment Loss (gain) on sale or disposal of assets Share-based Compensation Stock-based compensation expense Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts and Other Receivables Accounts and other receivables Increase (Decrease) in Prepaid Expense and Other Assets Prepaid and other current assets Increase (Decrease) in Other Operating Assets Other assets Increase (Decrease) in Accounts Payable and Accrued Liabilities Accounts payable and accrued expenses Increase (Decrease) in Other Operating Liabilities Other liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities: Proceeds from Sale and Maturity of Marketable Securities Sales and maturities of marketable securities Payments to Acquire Marketable Securities Purchases of marketable securities Payments to Acquire Property, Plant, and Equipment Acquisition of property and equipment Proceeds from Sale of Productive Assets Proceeds from sale or disposal of assets Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash flows from financing activities: Proceeds from Issuance of Common Stock Net proceeds from sale of common stock Net proceeds from stock issuances Proceeds from Stock Plans Proceeds from issuance of stock from employee benefit plans Proceeds from Issuance of Debt Issuance of term loan Repayments of Debt Payment of term loan Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net (decrease) increase in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Non-cash investing activities Construction in Progress Expenditures Incurred but Not yet Paid Accrued construction in progress Nature of Business and Overview Basis of Accounting [Text Block] Nature of Business and Overview Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Comprehensive Income (Loss) Note [Text Block] Accumulated Other Comprehensive Income Fair Value Measurements Fair Value Disclosures [Text Block] Fair Value Measurements Marketable Securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Marketable Securities Property and Equipment, Net Property, Plant and Equipment Disclosure [Text Block] Property and Equipment, Net Leases Lessee, Operating Leases [Text Block] Leases Intangible Assets Goodwill and Intangible Assets Disclosure [Text Block] Intangible Assets Accrued Expenses Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Accrued Expenses Other Long-Term Liabilities Other Liabilities Disclosure [Text Block] Other Long-Term Liabilities Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Stockholders' Equity Stock-Based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-Based Compensation Revenue Revenue from Contract with Customer [Text Block] Revenue Collaboration Agreements Collaborative Arrangement Disclosure [Text Block] Collaboration Agreements Income Taxes Income Tax Disclosure [Text Block] Income Taxes Retirement Savings Plan Pension and Other Postretirement Benefits Disclosure [Text Block] Retirement Savings Plan Kolltan Acquisition Business Combination Disclosure [Text Block] Kolltan Acquisition Basis of Accounting, Policy [Policy Text Block] Basis of Presentation Use of Estimates, Policy [Policy Text Block] Use of Estimates Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Marketable Securities, Policy [Policy Text Block] Marketable Securities Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk and of Significant Customers and Suppliers Fair Value Measurement, Policy [Policy Text Block] Fair Value Measurements Property, Plant and Equipment, Policy [Policy Text Block] Property and Equipment Lessee, Leases [Policy Text Block] Leases Business Combinations Policy [Policy Text Block] Contingent Consideration Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block] Intangible Assets Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block] Impairment of Intangible and Long-Lived Assets