Document and Entity Information Statement [Table] Common Stock Income Taxes Document Type Document Period End Date Document Transition Report Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line Two Entity Address, Address Line Three Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Central Index Key Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Amendment Flag Document Quarterly Report CONDENSED CONSOLIDATED BALANCE SHEETS Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash and cash equivalents Available-for-sale Securities, Debt Securities, Current Marketable securities Fair Value Accounts and Other Receivables, Net, Current Accounts and other receivables Prepaid Expense and Other Assets, Current Prepaid and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Operating Lease, Right-of-Use Asset Operating lease right-of-use assets, net Intangible Assets, Net (Excluding Goodwill) Intangible assets, net Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Accrued Liabilities, Current Accrued expenses Operating Lease, Liability, Current Current portion of operating lease liabilities Other Liabilities, Current Less current portion Current portion of other long-term liabilities Liabilities, Current Total current liabilities Operating Lease, Liability, Noncurrent Long-term portion of operating lease liabilities Other Liabilities, Noncurrent Other long-term liabilities Long-term portion Liabilities Total liabilities Commitments and Contingencies. Commitments and contingent liabilities Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Convertible preferred stock, $.01 par value; 3,000,000 shares authorized; no shares issued and outstanding at September 30, 2021 and December 31, 2020 Common Stock, Value, Issued Common stock, $.001 par value; 297,000,000 shares authorized; 46,663,340 and 39,603,771 shares issued and outstanding at September 30, 2021 and December 31, 2020, respectively Additional Paid in Capital, Common Stock Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders Equity Balance Balance Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Convertible Preferred Stock, Par Value (in dollars per share) Preferred Stock, Shares Authorized Convertible Preferred Stock, Shares Authorized Preferred Stock, Shares Issued Convertible Preferred Stock, Shares Issued Preferred Stock, Shares Outstanding Convertible Preferred Stock, Shares Outstanding Common Stock, Par or Stated Value Per Share Common Stock, Par Value (in dollars per share) Common Stock, Shares Authorized Common Stock, Shares Authorized Common Stock, Shares, Issued Balance (in shares) Balance (in shares) Common Stock, Shares Issued Common Stock, Shares, Outstanding Common Stock, Shares Outstanding CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Revenues [Abstract] Revenues: Revenue from Contract with Customer, Excluding Assessed Tax Total revenues Revenues Costs and Expenses [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense General and administrative Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) Intangible asset impairment Intangible Asset Impairment Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset Gain on fair value remeasurement of contingent consideration (Gain) loss on fair value remeasurement of contingent consideration Gain on Fair Value Remeasurement of Contingent Consideration Costs and Expenses Total operating expenses Operating Income (Loss) Operating loss Interest and Other Income Investment and other income, net Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Net loss before income tax benefit Income Tax Expense (Benefit) Income tax benefit Income Tax Benefit Non-Cash Income Tax Benefit Net Income (Loss) Available to Common Stockholders, Basic Net loss Net loss Earnings Per Share, Basic and Diluted Basic and diluted net loss per common share Weighted Average Number of Shares Outstanding, Basic and Diluted Shares used in calculating basic and diluted net loss per share Accumulated Other Comprehensive Income Comprehensive loss: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income (loss): Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized (loss) gain on marketable securities Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash flows from operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: .Depreciation, Depletion and Amortization Depreciation and amortization Accretion (Amortization) of Discounts and Premiums, Investments Amortization and premium of marketable securities, net Gain (Loss) on Disposition of Property Plant Equipment Gain on sale or disposal of assets Share-based Compensation Stock-based compensation expense Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts and Other Receivables Accounts and other receivables Increase (Decrease) in Prepaid Expense and Other Assets Prepaid and other current assets Increase (Decrease) in Accounts Payable and Accrued Liabilities Accounts payable and accrued expenses Increase (Decrease) in Other Operating Liabilities Other liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities: Proceeds from Sale and Maturity of Marketable Securities Sales and maturities of marketable securities Payments to Acquire Marketable Securities Purchases of marketable securities Payments to Acquire Property, Plant, and Equipment Acquisition of property and equipment Proceeds from Sale of Productive Assets Proceeds from sale or disposal of assets Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash flows from financing activities: Proceeds from Issuance of Common Stock Net proceeds from sale of common stock Net proceeds from stock issuances Proceeds from Stock Plans Proceeds from issuance of stock from employee benefit plans Proceeds from Issuance of Debt Issuance of Term Loan Repayments of Debt Payment of Term Loan Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net increase in cash and cash equivalents Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Non-cash investing activities Construction in Progress Expenditures Incurred but Not yet Paid Accrued construction in progress Basis of Presentation Basis of Accounting [Text Block] Basis of Presentation Significant Accounting Policies Significant Accounting Policies [Text Block] Significant Accounting Policies Fair Value Measurements Fair Value Disclosures [Text Block] Fair Value Measurements Marketable Securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Marketable Securities Intangible Assets Goodwill and Intangible Assets Disclosure [Text Block] Intangible Assets Other Long-Term Liabilities Other Liabilities Disclosure [Text Block] Other Long-Term Liabilities Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Stockholders' Equity Stock-Based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-Based Compensation Comprehensive Income (Loss) Note [Text Block] Accumulated Other Comprehensive Income Revenue Revenue from Contract with Customer [Text Block] Revenue Income Taxes Income Tax Disclosure [Text Block] Income Taxes Net Loss Per Share Earnings Per Share [Text Block] Net Loss Per Share Kolltan Acquisition Business Combination Disclosure [Text Block] Kolltan Acquisition New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Fair Value, Assets Measured on Recurring Basis [Table Text Block] Schedule of financial assets and liabilities subject to fair value measurements Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Schedule of the contingent consideration liabilities measured at fair value using Level 3 inputs Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Schedule of marketable debt securities, classified as available-for-sale Schedule of Other Long Term Liabilities [Table Text Block] Schedule of other long-term liabilities Schedule of Stockholders Equity [Table Text Block] Schedule of Shareholder's equity Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of stock option activity Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Schedule of stock-based compensation expense Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of assumptions used for the fair value of employee stock options granted Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Schedule of changes in accumulated other comprehensive income Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of potentially dilutive common shares that have not been included in the net loss per common share calculations because the effect would have been anti-dilutive Unusual Risk or Uncertainty [Table] Unusual Risk or Uncertainty [Line Items] Cash, cash equivalents and marketable securities Indefinite-Lived Intangible Assets (Excluding Goodwill) Indefinite-lived intangible assets Fair Value Measurements, Recurring and Nonrecurring [Table] Measurement Frequency [Axis] Fair Value Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value Measurements Recurring [Member] Fair Value Measurements. Fair Value, Hierarchy [Axis] Fair Value Measurements Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value Inputs Level2 [Member] Level 2 Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair value measurements Assets: Cash and Cash Equivalents, Fair Value Disclosure Money market funds and cash equivalents Available-for-sale Securities Marketable securities Assets, Fair Value Disclosure Total financial assets at fair value Liabilities: Business Combination, Contingent Consideration, Liability Balance at end of period Balance at beginning of period Contingent milestones (Note 3) Kolltan acquisition contingent consideration Financial and Nonfinancial Liabilities, Fair Value Disclosure Total financial liabilities at fair value Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Contingent consideration liabilities measured at fair value Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Fair value adjustments included in operating expenses Business Combination, Contingent Consideration, Liability, Measurement Input Measurement input Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers out of Level 3 Asset transfer out of level 3 Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3 Asset transfer into level 3 Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers out of Level 3 Liabilities transfers out of level 3 Debt Securities, Available-for-sale [Table] Financial Instrument [Axis] Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] Financial Instruments [Domain] Corporate Debt Securities [Member] Corporate debt securities Schedule of Available-for-sale Securities [Line Items] Marketable Securities Available-for-sale Securities, Debt Maturities, Amortized Cost Basis, Fiscal Year Maturity [Abstract] Amortized Cost Available-for-sale Securities, Debt Maturities, Next Twelve Months, Amortized Cost Basis Maturing in one year or less Amount of available-for-sale debt securities at cost, net of adjustments, maturing in the second fiscal year through the third fiscal year following the latest fiscal year. Available For Sale Securities, Debt Maturities after One Through Three Years, Amortized Cost Maturing after one year through three years Available-for-sale Debt Securities, Amortized Cost Basis Amortized Cost Available-for-sale Securities, Gross Unrealized Gain [Abstract] Gross Unrealized Gains Represents the gross unrealized gains on securities, at a point in time, for those securities which are expected to mature within one year of the balance sheet date, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities within One Year Gross Unrealized Gain Maturing in one year or less Represents the gross unrealized gains on securities, at a point in time, for those securities which are expected to mature after one year and through three years from the balance sheet date, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities after One Through Three Years, Gross Unrealized Gain Maturing after one year through three years Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Gross Unrealized Gains Available For Sale Securities, Gross Unrealized Losses [Abstract] Gross Unrealized Losses