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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 8-K

CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934

Date of report (Date of earliest event reported): May 28, 2009

CELLDEX THERAPEUTICS, INC.
(Exact Name of Registrant as Specified in its Charter)

Delaware
(State or Other Jurisdiction
of Incorporation)
  0-15006
(Commission
File Number)
  13-3191702
(IRS Employer
Identification No.)
119 Fourth Avenue
Needham, Massachusetts
  02494-2725
(Address of principal executive offices)   (Zip Code)

Registrant's telephone number, including area code: (781) 433-0771

        Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

ý
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))


Item 1.01.    Entry into a Material Definitive Agreement

        On May 29, 2009, Celldex Therapeutics, Inc., a Delaware corporation ("Celldex"), announced that it entered into an Agreement and Plan of Merger dated as of May 28, 2009 (the "Merger Agreement") by and among Celldex, CuraGen Corporation, a Delaware corporation ("CuraGen"), and Cottrell Merger Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of Celldex (the "Merger Sub"). The Merger Agreement has been approved by the Boards of Directors of Celldex and CuraGen and is subject to customary closing conditions, including stockholder approvals. A copy of a press release announcing the merger is attached hereto as Exhibit 99.1 and is incorporated by reference herein.

        The Merger Agreement provides that, upon the terms and subject to the conditions set forth in the Merger Agreement, Merger Sub will merge with and into CuraGen (the "Merger"), with CuraGen being the surviving corporation of the Merger and becoming a wholly-owned subsidiary of Celldex.

        Under the terms of the Merger Agreement, other than shares of CuraGen's common stock, par value $0.01 per share (the "CuraGen Common Stock") held in treasury by CuraGen or beneficially owned by Celldex, each share of CuraGen Common Stock issued and outstanding immediately prior to the effective time of the Merger (the "Effective Time"), including shares of restricted stock, shall be converted into the right to receive a number of shares of Celldex's common stock, par value $0.01 ("Celldex Common Stock"), calculated pursuant to an exchange ratio described in the Merger Agreement (the "Exchange Ratio"). The aggregate purchase price payable in the Merger, which is initially set at $94,500,000, is subject to adjustment based, in part, on CuraGen's net cash position as of the Closing. The purchase price will adjust upward if CuraGen's Cash at Closing Amount (as defined in the Merger Agreement) exceeds $54,500,000 by $1.30 for each $1.00 of excess until the aggregate purchase price reaches $97,500,000, and thereafter by $1.00 for each $1.00 of excess up to a maximum aggregate purchase price of $100,000,000. The purchase price will adjust downward if CuraGen's Cash at Closing Amount is less than $54,500,000 by $1.00 for each $1.00 of the shortfall. The foregoing adjustment is described in further detail in the Merger Agreement. Notwithstanding the foregoing, the aggregate number of shares of Celldex Common Stock issuable pursuant to the Merger shall in no event exceed 58.0% or fall beneath 32.5% of the shares of Celldex Common Stock issued and outstanding immediately after the Effective Time. No fractional shares of Celldex Common Stock will be issued in connection with the Merger, and holders of CuraGen Common Stock will be entitled to receive cash in lieu thereof.

        Under the terms of the Merger Agreement, Celldex shall, at the Effective Time, assume all CuraGen stock options that were issued under CuraGen's 2007 Stock Plan and such options will fully vest and be converted into options to acquire a number of shares of Celldex Common Stock determined by multiplying the number of shares of CuraGen Common Stock subject to such options immediately prior to the Effective Time by the Exchange Ratio. Celldex shall not assume any of CuraGen's stock options that were issued under CuraGen's 1997 Stock Plan, which stock options will, to the extent not yet vested, fully vest and terminate and be of no further force and effect upon consummation of the Merger if not exercised prior to that time.

        Further, in connection with the Merger, Celldex shall execute a supplemental indenture (the "Supplemental Indenture") to that certain Indenture, dated as of February 17, 2004, between CuraGen and The Bank of New York (the "Indenture") in respect of CuraGen's 4.0% Convertible Subordinated Notes due February 15, 2011 (the "Notes") currently outstanding under the Indenture.

        The Merger Agreement provides that, upon consummation of the Merger, the size of the Board of Directors of Celldex (the "Board") will be set at nine members, consisting of (i) Celldex's eight current directors and (ii) one additional director agreed upon by Celldex and CuraGen, who is expected to be Timothy M. Shannon, M.D. (the "CuraGen Director").

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        Pursuant to the terms of the Merger Agreement, CuraGen is not permitted to solicit other proposals and may not share information or have discussions regarding alternative proposals, except in certain circumstances. CuraGen may terminate the Merger Agreement under certain circumstances, including if its board of directors determines in good faith that it has received a Superior Proposal (as defined in the Merger Agreement) and otherwise complies with certain terms of the Merger Agreement. In connection with such termination, CuraGen must pay to Celldex a termination fee of $3,500,000. Similarly, Celldex may terminate the Merger Agreement under certain circumstances. Celldex is also required to pay to CuraGen a termination fee of $3,500,000 in connection with certain terminations of the Merger Agreement by CuraGen.

        Each of CuraGen and Celldex has made customary representations and warranties in the Merger Agreement and has agreed to customary covenants, including covenants regarding the operation of the business of CuraGen and Celldex and its subsidiaries prior to the Closing. The Closing is subject to customary closing conditions, including (i) the approval by Celldex's shareholders of the issuance of shares of Celldex Common Stock pursuant to the Merger, (ii) the adoption of the Merger Agreement by CuraGen's shareholders, (iii) the absence of certain legal impediments to the consummation of the Merger, (iv) the filing of an effective registration statement on Form S-4 with respect to the shares of Celldex Common Stock to be issued in the Merger, (v) the execution by Celldex of a Supplemental Indenture in respect of the Notes and (vi) the receipt by each party of an opinion from its counsel to the effect that the Merger will qualify as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended.

        The foregoing description of the Merger Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Merger Agreement, which is filed as Exhibit 2.1 hereto and is incorporated herein by reference.

Cautionary Statements

        The Merger Agreement has been included to provide investors with information regarding its terms. Except for its status as a contractual document that establishes and governs the legal relations among the parties thereto with respect to the transactions described above, the Merger Agreement is not intended to be a source of factual, business or operational information about the parties.

        The Merger Agreement contains representations and warranties made by the parties to each other regarding certain matters. The assertions embodied in the representations and warranties are qualified by information in confidential disclosure schedules that the parties have exchanged in connection with signing the Merger Agreement. The disclosure schedules contain information that modifies, qualifies and creates exceptions to the representations and warranties. Moreover, certain representations and warranties may not be complete or accurate as of a particular date because they are subject to a contractual standard of materiality that is different from those generally applicable to stockholders and/or were used for the purpose of allocating risk among the parties rather than establishing certain matters as facts. Accordingly, you should not rely on the representations and warranties as characterizations of the actual state of facts at the time they were made or otherwise.

Item 8.01    Other Events

        On May 29, 2009, Celldex used an Investor Presentation document in connection with the Merger Agreement and the Merger, which is attached hereto as Exhibit 99.2, and a transcript of a conference call regarding the Merger Agreement and the Merger, which is attached hereto as Exhibit 99.3.

IMPORTANT ADDITIONAL INFORMATION WILL BE FILED WITH THE SEC

        In connection with the proposed Merger, Celldex will file with the Securities and Exchange Commission ("SEC") a Registration Statement on Form S-4 that will include a joint proxy statement of

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Celldex and CuraGen that also constitutes a prospectus of Celldex. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ THESE MATERIALS WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE COMPANY, THE SELLER AND THE MERGER. The joint proxy statement/prospectus and other relevant materials (when they become available) and any other documents filed by Celldex or CuraGen with the SEC may be obtained free of charge at the SEC's website at http://www.sec.gov. In addition, investors may obtain free copies of the documents filed with the SEC (i) by contacting Celldex's Investor Relations at (781) 433-0771 or by accessing Celldex's investor relations website at www.celldextherapeutics.com; or (ii) by contacting CuraGen's Investor Relations at (203) 871-4400 or by accessing CuraGen's investor relations website at www.curagen.com. Investors and security holders are urged to read the joint proxy statement/prospectus and the other relevant materials when they become available before making any voting or investment decision with respect to the transaction.

Participants in the Solicitation

        The directors and executive officers of Celldex and CuraGen may be deemed to be participants in the solicitation of proxies from the holders of Celldex and CuraGen common stock in respect of the proposed Merger. Information about the directors and executive officers of Celldex and CuraGen are set forth in Celldex's and CuraGen's most recent Form 10-K and Form 10-K/A, which were filed with the SEC on March 5, 2009 and April 30, 2009, respectively. Investors may obtain additional information regarding the interest of Celldex and its directors and executive officers, and CuraGen and its directors and executive officers in the proposed Merger, by reading the joint proxy statement/prospectus regarding the Merger when it becomes available.

        This communication shall not constitute an offer to sell or the solicitation of an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction.

Item 9.01    Financial Statements and Exhibits

        (d) Exhibits

Exhibit No.   Description
  Exhibit 2.1   Agreement and Plan of Merger, dated as of May 28, 2009, by and among Celldex Therapeutics, Inc., CuraGen Corporation and Cottrell Merger Sub, Inc.

 

Exhibit 99.1

 

Joint Press release issued by Celldex Therapeutics, Inc. and CuraGen Corporation, dated May 29, 2009.

 

Exhibit 99.2

 

Celldex Therapeutics, Inc. Investor Presentation, May 29, 2009.

 

Exhibit 99.3

 

Transcript of conference call, May 29, 2009.

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SIGNATURE

        Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

    CELLDEX THERAPEUTICS, INC.

 

 

By:

 

/s/ AVERY W. CATLIN

Name: Avery W. Catlin
Title:
Senior Vice President/Chief Financial Officer
Dated: May 29, 2009        

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EXHIBIT INDEX

Exhibit No.   Description
  Exhibit 2.1   Agreement and Plan of Merger, dated as of May 28, 2009, by and among Celldex Therapeutics, Inc., CuraGen Corporation and Cottrell Merger Sub, Inc.(1)

 

Exhibit 99.1

 

Joint Press release issued by Celldex Therapeutics, Inc. and CuraGen Corporation, dated May 29, 2009.

 

Exhibit 99.2

 

Celldex Therapeutics, Inc. Investor Presentation, May 29, 2009.

 

Exhibit 99.3

 

Transcript of conference call, May 29, 2009.

(1)
The schedules to this agreement have been omitted from this filing. Celldex will furnish copies of any such schedules to the U.S. Securities and Exchange Commission upon request.

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EXHIBIT 2.1

AGREEMENT AND PLAN OF MERGER

BY AND AMONG

CELLDEX THERAPEUTICS, INC.,

COTTRELL MERGER SUB, INC.

AND

CURAGEN CORPORATION

May 28, 2009


TABLE OF CONTENTS

 
   
  Page

ARTICLE I DEFINITIONS

  1
   

1.1

 

Definitions

 
1
   

1.2

 

Terms Generally

  8

ARTICLE II THE MERGER

 
8
   

2.1

 

The Merger

 
8
   

2.2

 

Closing

  9
   

2.3

 

Effective Time

  9
   

2.4

 

Effects of the Merger

  9
   

2.5

 

Organizational Documents

  9
   

2.6

 

Directors and Officers of Surviving Corporation

  9
   

2.7

 

Closing Statement

  9
   

2.8

 

Disagreements Regarding Closing Statement

  10
   

2.9

 

Transaction Expenses

  11

ARTICLE III EFFECT OF THE MERGER ON THE CAPITAL STOCK OF THE CONSTITUENT CORPORATIONS

 
11
   

3.1

 

Conversion of Securities

 
11
   

3.2

 

Fractional Shares; Adjustments

  13
   

3.3

 

Exchange of Certificates

  13
   

3.4

 

Treatment of Options

  15

ARTICLE IV REPRESENTATIONS AND WARRANTIES OF THE COMPANY

 
16
   

4.1

 

Corporate Existence and Power

 
16
   

4.2

 

Corporate Authorization

  16
   

4.3

 

Governmental Authorization

  17
   

4.4

 

Non-Contravention

  17
   

4.5

 

Capitalization; Subsidiaries

  17
   

4.6

 

Reports and Financial Statements; Cash

  19
   

4.7

 

Undisclosed Liabilities

  20
   

4.8

 

Absence of Certain Changes or Events

  21
   

4.9

 

Litigation

  21
   

4.10

 

Taxes

  21
   

4.11

 

Employee Benefit Plans

  22
   

4.12

 

Compliance With Laws

  25
   

4.13

 

Finders' Fees

  25
   

4.14

 

Opinion of Financial Advisor

  25
   

4.15

 

Affiliate Transactions

  25
   

4.16

 

Anti-Takeover Provisions

  25
   

4.17

 

Voting

  26
   

4.18

 

Contracts

  26
   

4.19

 

Labor and Employee Matters

  27
   

4.20

 

Environmental

  27
   

4.21

 

Property

  28
   

4.22

 

Intellectual Property; Software

  28
   

4.23

 

Insurance

  29
   

4.24

 

Certain Business Practices

  30

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  Page
   

4.25

 

Suppliers And Manufacturers; Effect Of Transaction

  30
   

4.26

 

Government Contracts

  30
   

4.27

 

FDA Regulatory Compliance

  30

ARTICLE V REPRESENTATIONS AND WARRANTIES OF BUYER AND MERGER SUB

 
31
   

5.1

 

Corporate Existence and Power

 
32
   

5.2

 

Corporate Authorization

  32
   

5.3

 

Governmental Authorization

  32
   

5.4

 

Non-Contravention

  32
   

5.5

 

Capitalization

  32
   

5.6

 

SEC Reports

  33
   

5.7

 

Undisclosed Liabilities

  35
   

5.8

 

Absence of Certain Changes or Events

  35
   

5.9

 

Taxes

  35
   

5.10

 

Litigation

  36
   

5.11

 

Environmental

  36
   

5.12

 

Intellectual Property; Software

  36
   

5.13

 

FDA Regulatory Compliance

  37
   

5.14

 

Suppliers And Manufacturers; Effect Of Transaction

  38
   

5.15

 

No Breach of Designated Contracts

  38
   

5.16

 

Finders' Fees

  39
   

5.17

 

Opinion of Financial Advisor

  39
   

5.18

 

Merger Sub Operations

  39
   

5.19

 

Ownership of Company Common Stock

  39

ARTICLE VI CONDUCT OF BUSINESS PENDING THE MERGER

 
39
   

6.1

 

Conduct of the Company

 
39
   

6.2

 

Conduct of Buyer

  42
   

6.3

 

No Control of Other Party's Business

  43

ARTICLE VII ADDITIONAL AGREEMENTS

 
43
   

7.1

 

Stockholder Meetings; Joint Proxy Statement/Prospectus

 
43
   

7.2

 

Reasonable Best Efforts

  46
   

7.3

 

Access to Information

  46
   

7.4

 

Solicitation

  46
   

7.5

 

Director and Officer Liability

  49
   

7.6

 

Takeover Statutes

  50
   

7.7

 

Public Announcements

  50
   

7.8

 

Notice of Certain Events

  50
   

7.9

 

Employee Matters

  51
   

7.10

 

Listing

  52
   

7.11

 

Tax Matters

  52
   

7.12

 

Stockholder Litigation

  52
   

7.13

 

Exemption from Liability Under Section 16(b)

  52
   

7.14

 

Board of Directors of Buyer

  53

ARTICLE VIII CONDITIONS TO THE MERGER

 
53
   

8.1

 

Conditions to the Obligations of Each Party

 
53
   

8.2

 

Conditions to the Obligations of Buyer and Merger Sub

  53
   

8.3

 

Conditions to the Obligations of the Company

  54

ii


 
   
  Page

ARTICLE IX TERMINATION

  55
   

9.1

 

Termination

 
55
   

9.2

 

Termination Fee

  57
   

9.3

 

Effect of Termination

  57

ARTICLE X MISCELLANEOUS

 
58
   

10.1

 

Notices

 
58
   

10.2

 

Representations and Warranties

  58
   

10.3

 

Expenses

  59
   

10.4

 

Amendment

  59
   

10.5

 

Waiver

  59
   

10.6

 

Successors and Assigns

  59
   

10.7

 

Governing Law

  59
   

10.8

 

Counterparts; Effectiveness; Third Party Beneficiaries

  59
   

10.9

 

Severability

  59
   

10.10

 

Entire Agreement

  59
   

10.11

 

Remedies

  60
   

10.12

 

Jurisdiction

  60
   

10.13

 

Headings

  60
   

10.14

 

Further Assurances

  60
   

10.15

 

Authorship

  60

INDEX OF SCHEDULES AND EXHIBITS

Exhibit A    Form of Certificate of Incorporation of Surviving Corporation

Exhibit B    Form of Bylaws of Merger Sub

Buyer Disclosure Letter

Company Disclosure Letter

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AGREEMENT AND PLAN OF MERGER

        This AGREEMENT AND PLAN OF MERGER (this "Agreement") is made and entered into as of May 28, 2009, by and among CuraGen Corporation, a Delaware corporation (the "Company"), Celldex Therapeutics, Inc., a Delaware corporation ("Buyer") and Cottrell Merger Sub, Inc., a Delaware corporation and a direct wholly owned subsidiary of Buyer ("Merger Sub").

RECITALS

        WHEREAS, the parties intend that Merger Sub be merged with and into the Company upon the terms set forth herein, with the Company surviving the Merger as a wholly owned subsidiary of Buyer;

        WHEREAS the Board of Directors of the Company has (i) determined that it is in the best interests of the Company and its stockholders, and declared it advisable, to enter into this Agreement, (ii) approved this Agreement in accordance with the DGCL, and (iii) resolved to recommend the adoption of this Agreement by the stockholders of the Company;

        WHEREAS, the Board of Directors of each of Buyer and Merger Sub has approved and declared it advisable for Buyer and Merger Sub to enter into this Agreement;

        WHEREAS, the parties intend to adopt this Agreement as a plan of reorganization and for the Merger to qualify as a reorganization within the meaning of Section 368(a) of the Code and the Treasury Regulations promulgated thereunder; and

        WHEREAS, the Company, Buyer and Merger Sub desire to make certain representations, warranties, covenants and agreements in connection with the Merger and also to prescribe certain conditions to the Merger, as set forth herein.

AGREEMENT

        NOW, THEREFORE, in consideration of the foregoing and the representations, warranties, covenants and agreements contained herein, intending to be legally bound, the parties hereto agree as follows:

ARTICLE I
DEFINITIONS

        1.1    Definitions.    For purposes of this Agreement, the following terms have the respective meanings set forth below:

        "Accountant" has the meaning set forth in Section 2.8(a).

        "Acquisition Agreement" has the meaning set forth in Section 7.4(d).

        "Affiliate" means, with respect to any Person, any other Person, directly or indirectly, controlling, controlled by, or under common control with, such Person. For purposes of this definition, the term "control" (including the correlative terms "controlling," "controlled by" and "under common control with") means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of a Person, whether through the ownership of voting securities, by contract or otherwise.

        "Aggregate Exercise Price" has the meaning set forth in Section 3.1(b)(i).

        "Agreement" has the meaning set forth in the Preamble.

        "Assumed Options" means all options to acquire Company Common Stock granted under the 2007 Stock Plan outstanding immediately prior to the Effective Time.

        "Book Entry Shares" has the meaning set forth in Section 3.3(b).

        "Business Day" means any day other than the days on which banks in New York, New York are required or authorized to close.


        "Buyer" has the meaning set forth in the Preamble.

        "Buyer Balance Sheet Date" has the meaning set forth in Section 5.8.

        "Buyer Common Stock" has the meaning set forth in Section 3.1(b).

        "Buyer Common Stock Per Share Value" has the meaning set forth in Section 3.1(b)(ii).

        "Buyer Designated Contract" has the meaning set forth in Section 5.15.

        "Buyer Disclosure Letter" has the meaning set forth in the preamble to Article V.

        "Buyer Intellectual Property" has the meaning set forth in Section 5.12(a).

        "Buyer IP Licenses" has the meaning set forth in Section 5.12(a).

        "Buyer Material Adverse Effect" means any Effect that has had, or could reasonably be expected to have, individually or in the aggregate, a material adverse effect on the business, properties, assets, liabilities (contingent or otherwise), results of operations or condition (financial or otherwise) of Buyer; provided, however, that in no event shall any of the following, to the extent occurring after the date hereof, alone or in combination with each other, be deemed to constitute, nor shall any of the following be taken into account in determining whether there has been, a Buyer Material Adverse Effect: (A) any change in the market price or trading volume of the Buyer Common Stock, (B) any change in general economic or business conditions except to the extent that such changes have a materially disproportionate adverse effect on Buyer relative to other similarly situated participants in the business or industry in which Buyer operates, (C) any change in financial or securities market conditions generally, except to the extent that such changes have a disproportionate adverse effect on Buyer relative to other similarly situated participants in the business or industry in which Buyer operates, (D) any Effects generally affecting the United States biotechnology industry except to the extent that such changes have a disproportionate adverse effect on Buyer relative to other similarly situated participants in the business or industry which Buyer operates, (E) any change in legal, political or regulatory conditions generally or in any geographic region in which Buyer or any of its Subsidiaries operates except to the extent that such changes have a disproportionate adverse effect on Buyer relative to other similarly situated participants in the business or industry which Buyer operates, (F) the announcement of the execution of this Agreement or anticipation of the Merger or the pendency thereof, (G) acts of war, armed hostilities, sabotage or terrorism, or any escalation of any such acts of war, armed hostilities, sabotage or terrorism threatened or underway as of the date of this Agreement, except to the extent that such changes have a disproportionate adverse effect on Buyer relative to other similarly situated participants in the business or industry and in any geographic region in which Buyer operates or (H) any failure to meet any internal or published projections, forecasts or revenue or earnings predictions for any period, or (I) changes in Law or GAAP after the date of this Agreement.

        "Buyer Objection Statement" has the meaning set forth in Section 2.8(a).

        "Buyer Recommendation" has the meaning set forth in Section 7.1(a).

        "Buyer Recommendation Withdrawal" has the meaning set forth in Section 7.1(d).

        "Buyer Registrations" has the meaning set forth in Section 5.13(b).

        "Buyer Sale" means any acquisition in any manner, directly or indirectly (whether in a single transaction or a series of related transactions and whether effected as a merger, consolidation, sale of all or substantially all of the assets, sale of stock or other similar transaction) of more than 50% of any class of equity securities of the Buyer or acquisition in any manner, directly or indirectly (whether in a single transaction or a series of related transactions and including by means of license) of assets of the Buyer (including securities of Subsidiaries) equal to more than 50% of the Buyer's consolidated assets or to which more than 50% of the Buyer's consolidated revenues are attributable; in each case other

2



than the transactions contemplated by this Agreement."Buyer SEC Reports" has the meaning set forth in Section 5.6(a).

        "Buyer Securities" has the meaning set forth in Section 5.5(b).

        "Buyer Stockholder Meeting" has the meaning set forth in Section 7.1(d).

        "Buyer Termination Fee" means $3,500,000.

        "Cancelled Share" has the meaning set forth in Section 3.1(c).

        "Capitalization Date" has the meaning set forth in Section 4.5(b).

        "Cash" has the meaning set forth in Section 2.7(a).

        "Cash at Closing Amount" has the meaning set forth in Section 3.1(b)(iii).

        "Certificates" has the meaning set forth in Section 3.3(b).

        "Certificate of Merger" has the meaning set forth in Section 2.3.

        "Closing" has the meaning set forth in Section 2.2.

        "Closing Balance Sheet" has the meaning set forth in Section 2.7(b).

        "Closing Statement" has the meaning set forth in Section 2.7.

        "Closing Date" has the meaning set forth in Section 2.2.

        "Code" means the Internal Revenue Code of 1986, as amended.

        "Common Stock Exchange Ratio" has the meaning set forth in Section 3.1(b)(iv).

        "Company" has the meaning set forth in the Preamble.

        "Company Acquisition Proposal" means any inquiry, proposal or offer from any Person or "group" (as defined in Section 13(d) of the Exchange Act), other than Buyer and its Subsidiaries, relating to any (i) merger, consolidation, liquidation, dissolution, sale of substantial assets, tender offer, recapitalization, share exchange, business combination or similar transaction involving the Company or any of its Subsidiaries, (ii) acquisition in any manner, directly or indirectly (whether in a single transaction or a series of related transactions) of 15% or more of any class of equity securities of the Company or any of its Subsidiaries or (iii) acquisition in any manner, directly or indirectly (whether in a single transaction or a series of related transactions and including by means of license) of assets of the Company or any of its Subsidiaries (including securities of Subsidiaries) equal to 15% or more of the Company's consolidated assets or to which 15% or more of the Company's consolidated revenues are attributable; in each case other than the transactions contemplated by this Agreement.

        "Company Balance Sheet Date" has the meaning set forth in Section 4.8.

        "Company Benefit Plan" has the meaning set forth in Section 4.11(a).

        "Company Common Stock" has the meaning set forth in Section 3.1(b).

        "Company Common Stock Per Share Value" has the meaning set forth in Section 3.1(b)(v).

        "Company Disclosure Letter" has the meaning set forth in the preamble to Article IV.

        "Company Employees" has the meaning set forth in Section 4.11(a).

        "Company Insiders" has the meaning set forth in Section 7.13(c).

        "Company Intellectual Property" has the meaning set forth in Section 4.22(a).

        "Company IP Licenses" has the meaning set forth in Section 4.22(a).

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        "Company Options" means all options to acquire Company Common Stock granted under the Company Stock Plans outstanding immediately prior to the Effective Time.

        "Company Registrations" has the meaning set forth in Section 4.27(b).

        "Company Rights" has the meaning set forth in Section 4.5(a).

        "Company SEC Reports" has the meaning set forth in Section 4.6(a).

        "Company Securities" has the meaning set forth in Section 4.5(c).

        "Company Stockholder Meeting" has the meaning set forth in Section 4.2.

        "Company Stock Plans" has the meaning set forth in Section 4.5(b)(i).

        "Company Termination Fee" means $3,500,000.

        "Confidentiality Agreement" means the Confidentiality Agreement between Buyer and the Company, dated as of March 24, 2009.

        "Continuing Employees" has the meaning set forth in Section 7.9(a).

        "Contract" has the meaning set forth in Section 4.4.

        "Convertible Notes" has the meaning set forth in Section 4.5(b)(v).

        "Copyrights" has the meaning set forth in Section 4.22(a).

        "Current Policy" has the meaning set forth in Section 7.5(c).

        "Designated Severance Obligations" has the meaning set forth in Section 3.1(b)(vi).

        "DGCL" has the meaning set forth in Section 2.1.

        "DOL" has the meaning set forth in Section 4.11(a).

        "Effect" means any change, event, effect, fact or state of circumstances.

        "Effective Time" has the meaning set forth in Section 2.3.

        "End Date" has the meaning set forth in Section 9.1(b)(i).

        "Engagement Letter" has the meaning set forth in Section 4.13.

        "Environmental Laws" means all applicable federal, state, local and foreign Laws (including international conventions, protocols and treaties), common law, rules, regulations, orders, decrees, judgments, binding agreements or Environmental Permits issued, promulgated or entered into, by or with any Governmental Authority, relating to pollution, the release of or exposure to Hazardous Materials, natural resources or the protection, investigation or restoration of the environment as in effect on the date of this Agreement.

        "Environmental Permits" means all permits, licenses, registrations and other governmental authorizations required under applicable Environmental Laws.

        "ERISA" means the Employee Retirement Income Security Act of 1974, as amended.

        "ERISA Affiliate" has the meaning set forth in Section 4.11(b).

        "Excess Cash at Closing" has the meaning set forth in Section 3.1(b)(viii)(B).

        "Exchange Act" means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

        "Exchange Agent" has the meaning set forth in Section 3.3(a).

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        "Exchange Fund" has the meaning set forth in Section 3.3(a).

        "Exercise Period" has the meaning set forth in Section 3.4(b).

        "FDA" has the meaning set forth in Section 4.27(a).

        "FDA Laws" has the meaning set forth in Section 4.27(a).

        "Form S-4" has the meaning set forth in Section 7.1(a)(i).

        "FTC" has the meaning set forth in Section 4.27(a).

        "FTC Laws" has the meaning set forth in Section 4.27(a).

        "GAAP" means United States generally accepted accounting principles.

        "Governmental Authority" means any nation or government or any agency, public or regulatory authority, instrumentality, department, commission, court, arbitrator, ministry, tribunal or board of any nation or government or political subdivision thereof, in each case, whether foreign or domestic and whether national, supranational, federal, provincial, state, regional, local or municipal.

        "Hazardous Materials" means (i) any substance that is listed, classified or regulated as hazardous or toxic or a pollutant or contaminant under any Environmental Laws; or (ii) any petroleum product or by-product, asbestos-containing material, lead-containing paint or plumbing, polychlorinated biphenyls, radioactive material, toxic molds or radon.

        "Indenture" means the indenture between the Company and the Bank of New York, as trustee, dated as of February 17, 2004, relating to the Convertible Notes.

        "Insurance Amount" has the meaning set forth in Section 7.5(c).

        "Intellectual Property" has the meaning set forth in Section 4.22(a).

        "In the Money Options" has the meaning set forth in Section 3.1(b)(vii).

        "IRS" has the meaning set forth in Section 4.11(a).

        "Joint Proxy Statement/Prospectus" has the meaning set forth in Section 7.1(a)(i).

        "Junior Preferred Stock" has the meaning set forth in Section 4.5(a).

        "Knowledge" means (a)(i) with respect to the Company, the actual knowledge of the individuals set forth in Schedule 1.1 of the Company Disclosure Letter and (ii) with respect to Buyer, the actual knowledge of the individuals set forth in Schedule 1.1 of the Buyer Disclosure Letter or (b) in the case of an individual, the actual knowledge of such individual.

        "Law" means applicable statutes, common laws, rules, ordinances, regulations, codes, orders, judgments, injunctions, writs, decrees, governmental guidelines or interpretations having the force of law or bylaws, in each case, of a Governmental Authority.

        "Leased Real Property" has the meaning set forth in Section 4.21(b).

        "Liens" means, with respect to any asset, any mortgage, lien, pledge, charge, security interest or encumbrance of any kind in respect of such asset.

        "Material Adverse Effect on the Company" means any Effect that has had, or could reasonably be expected to have, individually or in the aggregate, a material adverse effect on the business, properties, assets, liabilities (contingent or otherwise), results of operations or condition (financial or otherwise) of the Company; provided, however, that in no event shall any of the following, to the extent occurring after the date hereof, alone or in combination with each other, be deemed to constitute, nor shall any of the following be taken into account in determining whether there has been, a Material Adverse

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Effect on the Company: (A) any change in the market price or trading volume of the Company Common Stock, (B) any change in general economic or business conditions except to the extent that such changes have a materially disproportionate adverse effect on the Company relative to other similarly situated participants in the business or industry in which the Company operates, (C) any change in financial or securities market conditions generally, except to the extent that such changes have a disproportionate adverse effect on the Company relative to other similarly situated participants in the business or industry in which the Company operates, (D) any Effects generally affecting the United States biotechnology industry except to the extent that such changes have a disproportionate adverse effect on the Company relative to other similarly situated participants in the business or industry which the Company operates, (E) any change in legal, political or regulatory conditions generally or in any geographic region in which the Company operates except to the extent that such changes have a disproportionate adverse effect on the Company relative to other similarly situated participants in the business or industry which the Company operates, (F) the announcement of the execution of this Agreement or anticipation of the Merger or the pendency thereof, (G) acts of war, armed hostilities, sabotage or terrorism, or any escalation of any such acts of war, armed hostilities, sabotage or terrorism threatened or underway as of the date of this Agreement, except to the extent that such changes have a disproportionate adverse effect on the Company relative to other similarly situated participants in the business or industry and in any geographic region in which the Company operates or (H) any failure to meet any internal or published projections, forecasts or revenue or earnings predictions for any period, or (I) changes in Law or GAAP after the date of this Agreement.

        "Material Contracts" has the meaning set forth in Section 4.18(b).

        "Material Licenses" has the meaning set forth in Section 4.18(b).

        "Materials of Environmental Concern" shall mean any hazardous, acutely hazardous, or toxic substance or waste defined and regulated as such under applicable Environmental Laws, including the federal Comprehensive Environmental Response, Compensation and Liability Act or the federal Resource Conservation and Recovery Act.

        "Merger" has the meaning set forth in Section 2.1.

        "Merger Sub" has the meaning set forth in the Preamble.

        "Multiemployer Plan" has the meaning set forth in Section 4.11(b).

        "NASDAQ" has the meaning set forth in Section 3.2(a).

        "Non-Voting Common Stock" has the meaning set forth in Section 4.5(a).

        "Patents" has the meaning set forth in Section 4.22(a).

        "Permits" means any licenses, franchises, permits, certificates, consents, approvals or other similar authorizations of, from or by a Governmental Authority possessed by or granted to or necessary for the ownership of the material assets or conduct of the business of the applicable party.

        "Permitted Liens" means (i) Liens for Taxes, assessments and governmental charges or levies not yet due and payable or that are being contested in good faith and by appropriate proceedings; (ii) mechanics', carriers', workmen's, repairmen's, materialmen's or other Liens or security interests that arise in the ordinary course of business or that are being contested in good faith and by appropriate proceedings; (iii) pledges or deposits to secure obligations under workers' compensation Laws or similar legislation or to secure public or statutory obligations; (iv) pledges and deposits to secure the performance of bids, trade contracts, leases, surety and appeal bonds, performance bonds and other obligations of a similar nature, in each case in the ordinary course of business; and (v) easements, covenants and rights of way (unrecorded and of record) and other similar restrictions of record, and zoning, building and other similar restrictions, in each case that do not adversely affect in any material

6



respect the current use of the applicable property owned, leased, used or held for use by a party or any of its Subsidiaries.

        "Person" means any individual, corporation, company, limited liability company, partnership, association, trust, joint venture or any other entity or organization, including any government or political subdivision or any agency or instrumentality thereof.

        "Purchase Price" has the meaning set forth in Section 3.1(b)(viii).

        "Pre-Closing Period" has the meaning set forth in Section 6.1.

        "Preferred Stock" has the meaning set forth in Section 4.5(a).

        "Proceeding" has the meaning set forth in Section 5.10.

        "PSV Policies" has the meaning set forth in Section 7.9(b).

        "Real Property Lease" has the meaning set forth in Section 4.21(b).

        "Recommendation" has the meaning set forth in Section 7.1(a)(i).

        "Recommendation Withdrawal" has the meaning set forth in Section 7.4(a).

        "Representatives" has the meaning set forth in Section 7.4(a).

        "Required Stockholders Meetings" has the meaning set forth in Section 7.1(d).

        "Requisite Company Stockholder Vote" means the affirmative vote of the holders of a majority of the voting power of the Company Common Stock.

        "Requisite Buyer Stockholder Vote" means the majority of the total votes cast by holders of the Buyer Common Stock at the Buyer Stockholder Meeting.

        "Restricted Shares" has the meaning set forth in Section 4.5(b)(i).

        "Rights Plan" has the meaning set forth in Section 4.5(a).

        "Sarbanes-Oxley Act" has the meaning set forth in Section 4.6(a).

        "SEC" means the United States Securities and Exchange Commission.

        "Section 16 Information" has the meaning set forth in Section 7.13(b).

        "Securities Act" means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

        "Severance Amount" has the meaning set forth in Section 4.5(h).

        "Software" has the meaning set forth in Section 4.22(a).

        "Statement" has the meaning set forth in Section 2.7.

        "Subsidiary," with respect to any Person, means any other Person of which the first Person owns, directly or indirectly, securities or other ownership interests having voting power to elect a majority of the board of directors or other persons performing similar functions (or, if there are no such voting interests, more than 50% of the equity interests of the second Person).

        "Superior Proposal" has the meaning set forth in Section 7.4(b).

        "Supplemental Indenture" means a supplemental indenture whereby the Buyer assumes the Company's obligations under the Indenture.

        "Surviving Corporation" has the meaning set forth in Section 2.1.

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        "Surviving Corporation Plan" has the meaning set forth in Section 7.9(c).

        "Tax" means (A) all federal, state, local or foreign taxes, charges, fees, imposts, levies or other comparable assessments, in each case in the nature of a tax, including all income, gross receipts, capital, sales, use, ad valorem, value added, transfer, franchise, profits, inventory, capital stock, license, withholding, payroll, employment, social security, unemployment, excise, severance, stamp, occupation, property, alternative and estimated taxes, customs duties, fees, assessments and other charges in the nature of Taxes imposed by any Tax authority or Governmental Entity, (B) all interest, penalties, fines, additions to tax or additional amounts imposed by any Tax authority or Governmental Entity in connection with any item described in clauses (A) or (B), and (C) any amounts in respect of any items described in clauses (A) and/or (B) payable by reason of contract, assumption, transferee liability, operation of Law, Treasury Regulation Section 1.1502-6(a) (or any predecessor or successor thereof or any analogous or similar provision under federal, state, local or foreign Law) or otherwise.

        "Tax Return" means any return, declaration, report, statement, information statement or other document, together with all associated schedules, filed or required to be filed with a Governmental Authority with respect to Taxes, including any claims for refunds of Taxes, any information returns and any amendments or supplements of any of the foregoing.

        "Trademarks" has the meaning set forth in Section 4.22(a).

        "Trade Secrets" has the meaning set forth in Section 4.22(a).

        "Transaction Expenses" has the meaning set forth in Section 3.1(b)(ix).

        "1993 Stock Plan" has the meaning set forth in Section 4.5(b)(iv).

        "1997 Plan Options" has the meaning set forth in Section 3.4(b).

        "1997 Stock Plan" has the meaning set forth in Section 4.5(b)(i).

        "2007 Stock Plan" has the meaning set forth in Section 4.5(b)(i).

        "2009 Budget" has the meaning set forth in Section 6.1(l).

        1.2    Terms Generally.    The definitions in Section 1.1 shall apply equally to both the singular and plural forms of the terms defined. Whenever the context may require, any pronoun shall include the corresponding masculine, feminine and neuter forms. The words "include," "includes" and "including" shall be deemed to be followed by the phrase "without limitation," unless the context expressly provides otherwise. All references herein to Sections, paragraphs, subparagraphs, clauses, Exhibits or Schedules shall be deemed references to Sections, paragraphs, subparagraphs or clauses of, or Exhibits or Schedules to this Agreement, unless the context requires otherwise. Unless otherwise expressly defined, terms defined in this Agreement have the same meanings when used in any Exhibit or Schedule hereto, including the Company Disclosure Letter. Unless otherwise specified, the words "this Agreement," "herein," "hereof," "hereto" and "hereunder" and other words of similar import refer to this Agreement as a whole (including the Schedules, Exhibits and the Company Disclosure Letter) and not to any particular provision of this Agreement.

ARTICLE II
THE MERGER

        2.1    The Merger.    On the terms and subject to the conditions set forth in this Agreement, and in accordance with the General Corporation Law of the State of Delaware (the "DGCL"), at the Effective Time, Merger Sub will merge with and into the Company (the "Merger"), the separate corporate existence of Merger Sub will cease and the Company will continue its corporate existence under the DGCL as the surviving corporation in the Merger (the "Surviving Corporation").

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        2.2    Closing.    Unless otherwise mutually agreed in writing by the Company and Buyer, the closing of the Merger (the "Closing") will take place at the offices of Lowenstein Sandler PC, 65 Livingston Ave., Roseland, New Jersey, at 10:00 a.m. on the second Business Day after the satisfaction or waiver of the conditions set forth in Article VIII (excluding conditions that, by their terms, cannot be satisfied until the Closing but subject to the satisfaction or waiver of such conditions at the Closing), or at such other place, date and time as the Company and Buyer may agree in writing. The date on which the Closing actually occurs is hereinafter referred to as the "Closing Date."

        2.3    Effective Time.    Subject to the provisions of this Agreement, at the Closing, the parties hereto shall cause the Merger to be consummated by executing and filing a certificate of merger (the "Certificate of Merger") with the Secretary of State of the State of Delaware in accordance with the DGCL. The Merger will become effective at such date and time as the Certificate of Merger has been duly filed with and accepted for recording by the Secretary of State of the State of Delaware or at such later date or time as may be agreed by the Company and Buyer in writing and specified in the Certificate of Merger in accordance with the DGCL (the effective time of the Merger being hereinafter referred to as the "Effective Time").

        2.4    Effects of the Merger.    The Merger shall have the effects set forth in this Agreement and the applicable provisions of the DGCL. Without limiting the generality of the foregoing, and subject thereto, from and after the Effective Time, all property, rights, privileges, immunities, powers, franchises, licenses and authority of the Company and Merger Sub shall vest in the Surviving Corporation, and all debts, liabilities, obligations, restrictions and duties of each of the Company and Merger Sub shall become the debts, liabilities, obligations, restrictions and duties of the Surviving Corporation.

        2.5    Organizational Documents.    At the Effective Time, (a) the Certificate of Incorporation of the Surviving Corporation shall be amended to read in its entirety in the form attached hereto as Exhibit A and (b) the bylaws of the Surviving Corporation shall be amended so as to read in their entirety as the bylaws of Merger Sub as in effect immediately prior to the Effective Time, in the form attached hereto as Exhibit B, until thereafter amended in accordance with applicable Law.

        2.6    Directors and Officers of Surviving Corporation.    The directors of the Company immediately prior to the Effective Time shall submit their resignations to be effective as of the Effective Time, which resignations shall be a condition of the Merger. Immediately after the Effective Time, Buyer shall take the necessary action to cause the directors of Merger Sub immediately prior to the Effective Time to be the directors of the Surviving Corporation, each to hold office in accordance with the certificate of incorporation and bylaws of the Surviving Corporation. The officers of the Merger Sub immediately prior to the Effective Time shall be the initial officers of the Surviving Corporation, each to hold office until the earlier of their resignation or removal.

        2.7    Closing Statement.    No later than three (3) Business Days prior to the Closing, the Company shall deliver a statement certified by the Chief Financial Officer of the Company, which shall set forth the Company's calculation of the Cash at Closing Amount and which shall include the items described in Section 2.7(a), (b) and (c), below (the "Statement"). During the period between Buyer's receipt of the Statement and the Closing, Buyer and the Company shall seek in good faith to resolve any differences that they may have with respect to the matters specified in the Statement and the Company shall afford to Buyer such access to its books and records related to the Statement as Buyer may deem necessary to verify the Statement. The Statement shall become final upon the earlier to occur of (i) the resolution (whether pursuant to the procedures set forth in Section 2.8 or otherwise) by Buyer and the Company of any disagreements they have with respect thereto (the "Closing Statement") or (ii) at 5:00 PM, New York time, on the second Business Day after the date the Company delivers the Statement to

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the Buyer, if Buyer has not notified the Company of any disagreements with respect to the Statement by that time. The Statement shall include the following:

        2.8    Disagreements Regarding Closing Statement.    

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        2.9    Transaction Expenses.    Concurrently with the delivery of the Statement and no later than three (3) Business Days prior to the Closing Date, the Company shall provide to Buyer the amount, in the aggregate, of all Transaction Expenses that have not been paid prior to Closing and shall provide Buyer with a certificate setting forth (a) the identity of each Person that is owed such amounts; (b) the amount owed or to be owed to each such Person; and (c) the bank account and wire transfer information for each such Person.

ARTICLE III
EFFECT OF THE MERGER ON THE CAPITAL STOCK
OF THE CONSTITUENT CORPORATIONS

        3.1    Conversion of Securities.    At the Effective Time, pursuant to this Agreement and by virtue of the Merger and without any action on the part of the Company, Buyer, Merger Sub or their stockholders:

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        3.2    Fractional Shares; Adjustments.    

        3.3    Exchange of Certificates.    

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        3.4    Treatment of Options.    

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ARTICLE IV
REPRESENTATIONS AND WARRANTIES OF THE COMPANY

        Except (i) as set forth in the disclosure letter (the "Company Disclosure Letter") delivered to Buyer and Merger Sub by the Company concurrently with entering into this Agreement (it being understood that any information set forth in one section or subsection of the Company Disclosure Letter shall be deemed to apply to and qualify the section or subsection of this Agreement to which it corresponds in number and each other section or subsection of this Agreement to which the relevance of such disclosure is readily apparent on its face), or (ii) as disclosed in the Company SEC Reports (as defined herein) filed prior to the date of this Agreement (other than any forward-looking disclosures set forth in any risk factor section, any disclosures in any section relating to forward-looking statements and any other similar disclosures included therein to the extent they are primarily predictive or forward-looking in nature), the Company hereby represents and warrants to Buyer and Merger Sub that:

        4.1    Corporate Existence and Power.    The Company is duly organized, validly existing and in good standing under the laws of its jurisdiction of organization. The Company has all corporate or similar powers and authority required to own, lease and operate its respective properties and to carry on its business as now conducted. The Company is duly licensed or qualified to do business in each jurisdiction in which the nature of the business conducted by it or the character or location of the properties and assets owned or leased by it makes such qualification necessary, except for any failures to be so licensed or qualified that would not reasonably be expected to have a Material Adverse Effect on the Company. The Company is not in violation of its organizational or governing documents in any respect.

        4.2    Corporate Authorization.    The Company has the corporate power and authority to execute and deliver this Agreement and, subject to the adoption of this Agreement by the Requisite Company Stockholder Vote, to consummate the Merger and the other transactions contemplated hereby and to perform each of its obligations hereunder. The execution, delivery and performance by the Company of this Agreement and the consummation by the Company of the Merger and the other transactions contemplated hereby have been duly and validly authorized by the Board of Directors of the Company. The Board of Directors of the Company at a duly held meeting has (i) determined that it is in the best interests of the Company and its stockholders to enter into this Agreement, (ii) approved the execution, delivery and performance of this Agreement and the consummation of the transactions contemplated hereby, including the Merger, and (iii) resolved to recommend that the stockholders of the Company approve the adoption of this Agreement and directed that such matter be submitted for consideration of the stockholders of the Company at a meeting called for the purpose of approving and adopting this Agreement (the "Company Stockholder Meeting").

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        4.3    Governmental Authorization.    The execution, delivery and performance by the Company of this Agreement and the consummation of the Merger by the Company do not and will not require any consent, approval, authorization or permit of, action by, filing with or notification to any Governmental Authority, other than (i) the filing of the Certificate of Merger; (ii) compliance with the applicable requirements of the Exchange Act, including the filing of the Form S-4; (iii) compliance with the rules and regulations of NASDAQ; (iv) compliance with any applicable foreign or state securities or blue sky laws; (v) such filings and consents as may be required under any environmental, health or safety law or regulation, or any health care licensure laws, reimbursement authorities and their agents, certificate of need laws and other health care laws and regulations, pertaining to any notification, disclosure or approval required by the Merger or the other transactions contemplated by this Agreement; and (vi) any such consent, approval, authorization, permit, action, filing or notification the failure of which to be made or obtained would not (A) individually or in the aggregate, reasonably be expected to have a Material Adverse Effect on the Company or (B) reasonably be expected to prevent or materially delay the consummation of the Merger.

        4.4    Non-Contravention.    Assuming compliance with the matters referenced in Section 5.3, the receipt of the Requisite Company Stockholder Vote and Buyer's execution of the Supplemental Indenture, the execution, delivery and performance by the Company of this Agreement and the consummation by the Company of the Merger and the other transactions contemplated hereby do not and will not (i) contravene or conflict with the organizational or governing documents of the Company; (ii) contravene or conflict with or constitute a violation of any provision of any Law binding upon or applicable to the Company, or any of its properties or assets; (iii) require the consent, approval or authorization of, or notice to or filing with any third party with respect to, result in any breach or violation of or constitute a default (or an event which with notice or lapse of time or both would become a default) or result in the loss of a benefit under, or give rise to any right of termination, cancellation, amendment or acceleration of any right or obligation of the Company, or result in the creation of any Lien on any of the properties or assets of the Company under, any loan or credit agreement, note, bond, mortgage, indenture, contract, agreement, lease, license, permit or other instrument or obligation (each, a "Contract") to which the Company is a party or by which the Company or its properties or assets are bound, except, in the case of clause (iii) above, as would not (A) individually or in the aggregate, reasonably be expected to have a Material Adverse Effect on the Company or (B) reasonably be expected to prevent or materially delay the consummation of the Merger.

        4.5    Capitalization; Subsidiaries.    

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        4.6    Reports and Financial Statements; Cash.    

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        4.7    Undisclosed Liabilities.    Except (i) for those liabilities that are reflected or reserved against on the balance sheet of the Company (including the notes thereto) included in the Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2009, (ii) for liabilities incurred that are reflected as current liabilities on the Closing Balance Sheet, (iii) for liabilities that have been discharged or paid in full prior to the date that is five Business Days prior to the date of this Agreement in the ordinary course of business consistent with past practice, and (iv) for liabilities in respect of the Transaction Expenses (whether absolute, accrued or contingent or otherwise and whether

20


due or to become due), the Company does not have any liabilities, commitments or obligations, asserted or unasserted, known or unknown, absolute or contingent, whether or not accrued, matured or un-matured or otherwise, of a nature required by GAAP to be reflected in a consolidated balance sheet or disclosed in the notes thereto.

        4.8    Absence of Certain Changes or Events.    Since the date of the financial statements included or incorporated by reference in the Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2009 (the "Company Balance Sheet Date"), (a) no Effect has occurred which has had or would reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect on the Company and (b) the Company has not taken or omitted to take any action that would, if taken or omitted to be taken after the date hereof, result in a breach of Section 6.1 of this Agreement.

        4.9    Litigation.    The Company is not a party to any, and there are no pending or, to the Company's Knowledge, threatened, Proceedings of any nature against the Company, in each case that, individually or in the aggregate, would reasonably be expected to have a Material Adverse Effect on the Company. Neither the Company, nor its business or properties is subject to or bound by any injunction, order, judgment, decree or regulatory restriction of any Governmental Authority specifically imposed upon the Company or its properties or assets.

        4.10    Taxes.    The representations and warranties contained in this Section 4.10 are the only representations and warranties made by the Company in this Agreement with respect to Tax matters. Except as would not reasonably be expected, individually or in the aggregate, to have a Material Adverse Effect on the Company:

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        4.11    Employee Benefit Plans.    

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        4.12    Compliance With Laws.    

        4.13    Finders' Fees.    No agent, broker, investment banker, financial advisor or other firm or person except Piper Jaffray is or will be entitled to any broker's or finder's fee or any other similar commission or fee in connection with any of the transactions contemplated by this Agreement based upon Contracts made by or on behalf of the Company. The Company has disclosed to Buyer all terms of the engagement of Piper Jaffray (the terms of such engagement, the "Engagement Letter"), including the amount of such fees and any right of first offer or other "tail" provisions, and the aggregate amount of fees payable or to become payable to Piper Jaffray is included in the Transaction Expenses.

        4.14    Opinion of Financial Advisor.    The Company has received the opinion of Piper Jaffray, dated May 28, 2009, to the effect that the Purchase Price is fair from a financial point of view to the holders of Company Common Stock, a copy of which opinion has been delivered to Buyer or will be delivered to Buyer promptly following the date of this Agreement.

        4.15    Affiliate Transactions.    Except for this Agreement and the Merger, there are no transactions, or series of related transactions, agreements, arrangements or understandings, between the Company, on the one hand, and the Company's Affiliates, on the other hand, that would be required to be disclosed under Item 404 of Regulation S-K promulgated under the Securities Act as currently applicable to the Company that are not so disclosed.

        4.16    Anti-Takeover Provisions.    Subject to the accuracy of the representation set forth in Section 5.19 hereof, the Board of Directors of the Company has taken and will take all actions necessary to ensure that the restrictions applicable to business combinations contained in Section 203 of the DGCL are, and will be, inapplicable to the execution, delivery and performance of this Agreement and to the consummation of the Merger and the other transactions contemplated by this Agreement.

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        4.17    Voting.    

        4.18    Contracts.    

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        4.19    Labor and Employee Matters.    With respect to the Company: (i) there has not been within the six (6) years preceding the Effective Time, and there are not now pending, or to the Company's Knowledge threatened, labor or employment controversies, including any Proceeding alleging unlawful harassment, employment discrimination or unfair labor practices; (ii) to the Company's Knowledge, no union organizing efforts are underway or threatened as of the date hereof with respect to any Company Employee; and (iii) there is, as of the date hereof, no strike, slowdown, work stoppage or lockout underway or, to the Company's Knowledge, threatened in writing. Section 4.19 of the Company Disclosure Letter sets forth a list of collective bargaining agreements with any labor organization to which Company is a party and a list of any labor organization with which Company is currently in labor negotiations. No "mass layoff," plant closing or similar event as defined by the Worker Adjustment and Retraining Notification Act (WARN) has occurred with respect to the Company during the six (6) years preceding the Effective Time. The Company does not have any liability for any payment to any trust or other fund governed by or maintained on behalf of any Governmental Authority with respect to unemployment compensation benefits, social security or other benefits or obligations of any employee, contractor or other service provider (other than routine payments to be made in the normal course of business consistent with past practice). Each Person classified as an independent contractor by the Company has satisfied the requirements of applicable Law to be so classified, and Company has fully and accurately reported such independent contractor's compensation on IRS Forms 1099 when required to do so. The Company has not entered into any written agreement, arrangement or understanding restricting its ability to terminate the employment of any Company Employee, for any lawful or no reason, without penalty or liability. The Company has not, directly or through agents and independent contractors, employed any unauthorized aliens, as defined in 8 U.S.C. Section 1324a(h)(3) and has complied, or caused any such agent or independent contractor, to comply with the employment verification and record-keeping requirements of 8 U.S.C. Section 1324a and 8 C.F.R. Section 274a, as amended. To the Company's Knowledge, the Company is in compliance with the Immigration and Nationality Act and the Immigration Reform and Control Act.

        4.20    Environmental.    (i) The Company is in compliance in all material respects with all applicable Environmental Laws, and possesses and complies in all material respects with all applicable Environmental Permits required under such Laws to operate as it presently operates; (ii) there are no Materials of Environmental Concern at any property owned or operated by the Company, under circumstances that are reasonably likely to result in a material liability of the Company under any applicable Environmental Law; (iii) neither the Company nor any of its Subsidiaries has received any written notification alleging that it is liable for, or request for information pursuant to section 104(e) of the Comprehensive Environmental Response, Compensation and Liability Act or similar state statute, concerning, any release or threatened release of Materials of Environmental Concern at any location except, with respect to any such notification or request for information concerning any such release or threatened release, to the extent such matter has been resolved with the appropriate foreign, federal,

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state or local regulatory authority or otherwise; and (iv) neither the Company nor any of its Subsidiaries has received any written claim or complaint, or is subject to any proceeding, relating to material noncompliance with Environmental Laws or any other material liabilities pursuant to Environmental Laws, and no such matter has been threatened in writing to the Knowledge of the Company.

        4.21    Property.    

        4.22    Intellectual Property; Software.    

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        4.23    Insurance.    The Company Disclosure Letter sets forth a list and brief description (including nature of coverage, limits, deductibles, premiums and the loss experience for the past three years with respect to each type of coverage) of all policies of insurance maintained, owned or held by the Company during the past three years. The Company shall use all reasonable best efforts to keep such insurance or comparable insurance in full force and effect through the Effective Time. The Company has complied in all material respects with each such insurance policy to which it is a party. Each such policy is in full force and effect and will not in any way be affected by or terminate or lapse by reason of the transactions contemplated by this Agreement.

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        4.24    Certain Business Practices.    Neither the Company nor, to the Knowledge of the Company, any director, officer, employee or agent of the Company has: (i) used any funds for unlawful contributions, gifts, entertainment or other unlawful payments relating to political activity; (ii) made any unlawful payment to any foreign or domestic government official or employee or to any foreign or domestic political party or campaign or violated any provision of the Foreign Corrupt Practices Act of 1977, as amended; or (iii) made any other unlawful payment.

        4.25    Suppliers And Manufacturers; Effect Of Transaction.    

        4.26    Government Contracts.    The Company has not been suspended or debarred from bidding on contracts with any Governmental Authority, and no such suspension or debarment has been initiated or, to the Knowledge of the Company, threatened. The consummation of the Merger and other transactions contemplated by this Agreement will not result in any such suspension or debarment of the Company.

        4.27    FDA Regulatory Compliance.    

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ARTICLE V
REPRESENTATIONS AND WARRANTIES OF BUYER
AND MERGER SUB

        Except (i) as set forth in the disclosure letter (the "Buyer Disclosure Letter") delivered to the Company by Buyer concurrently with entering into this Agreement (it being understood that any information set forth in one section or subsection of the Buyer Disclosure Letter shall be deemed to apply to and qualify the section or subsection of this Agreement to which it corresponds in number and each other section or subsection of this Agreement to which the relevance of such disclosure is readily apparent on its face) or (ii) as disclosed in the Buyer SEC Reports (as defined herein) filed prior to the date of this Agreement (other than any forward-looking disclosures set forth in any risk factor section, any disclosures in any section relating to forward-looking statements and any other similar

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disclosures included therein to the extent they are primarily predictive or forward-looking in nature), Buyer hereby represents and warrants to the Company that:

        5.1    Corporate Existence and Power.    Each of Buyer and Merger Sub is duly organized, validly existing and in good standing under the Laws of Delaware and has all corporate power and authority required to (a) carry on its business as presently conducted and (b) consummate the Merger and the other transactions contemplated hereby and to perform its obligations hereunder.

        5.2    Corporate Authorization.    Each of Buyer and Merger Sub has the corporate power and authority to execute and deliver this Agreement and, subject to the approval of the issuance of shares of Buyer Common Stock in connection with the Merger by the Requisite Buyer Stockholder Vote, to consummate the Merger and the other transactions contemplated hereby and to perform each of its obligations hereunder. The execution, delivery and performance by each of Buyer and Merger Sub of this Agreement and the consummation by Buyer and Merger Sub of the Merger and the other transactions contemplated hereby have been duly and validly authorized by the Board of Directors of Buyer and the Board of Directors of Merger Sub. This Agreement has been duly and validly executed and delivered by Buyer and, assuming the due and valid execution and delivery of the Agreement by the Company, constitutes a legal, valid and binding agreement of Buyer, enforceable against Buyer in accordance with its terms.

        5.3    Governmental Authorization.    The execution, delivery and performance by Buyer and Merger Sub of this Agreement and the consummation by Buyer and Merger Sub of the Merger do not and will not require any consent, approval, authorization or permit of, action by, filing with or notification to any Governmental Authority, other than (i) the filing of the Certificate of Merger; (ii) compliance with the applicable requirements of the Exchange Act; (iii) compliance with any applicable foreign or state securities or blue sky Laws; (iv) compliance with applicable environmental, health and safety Laws and regulations and any health care licensure Laws; and (v) any such consent, approval, authorization, permit, action, filing or notification the failure of which to make or obtain would not have or reasonably be expected to have a Buyer Material Adverse Effect.

        5.4    Non-Contravention.    Assuming approval of the issuance of shares of Buyer Common Stock in connection with the Merger by the Requisite Buyer Stockholder Vote and adoption of this Agreement by Buyer in its capacity as sole stockholder of Merger Sub (which Buyer shall cause to occur as soon as reasonably practicable following the execution of this Agreement), the execution, delivery and performance by Buyer and Merger Sub of this Agreement and the consummation by Buyer and Merger Sub of the Merger and the transactions contemplated hereby do not and will not (i) contravene or conflict with the organizational or governing documents of Buyer and Merger Sub, (ii) contravene, conflict with or constitute a violation of any provision of any Law binding upon or applicable to Buyer or Merger Sub or any of their respective properties or assets or (iii) require the consent, approval, or authorization of, or notice to or filing with any third party with respect to, result in any breach or violation of or constitute a default (or any event which with notice or lapse of time or both would become a default) under, or give rise to any right of termination, cancellation or acceleration of any right or obligation of Buyer or Merger Sub or to the loss of a material benefit to which Buyer is entitled under, or result in the creation of any Lien upon the properties or assets of Buyer or Merger Sub under, any Contract to which Buyer or Merger Sub is a party or by which it or any of its properties or assets are bound except in the case of clause (ii) or (iii) as would not have or reasonably be expected to have a Buyer Material Adverse Effect.

        5.5    Capitalization.    

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        5.6    SEC Reports.    

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        5.7    Undisclosed Liabilities.    Except (i) for those liabilities that are reflected or reserved against on the consolidated balance sheet of Buyer (including the notes thereto) included in Buyer's Quarterly Report on Form 10-Q for the quarter ended March 31, 2009, (ii) for liabilities incurred in the ordinary course of business consistent with past practice since March 31, 2009 that do not exceed $250,000 in the aggregate and (iii) for liabilities that have been discharged or paid in full prior to the date that is five (5) Business Days prior to the date of this Agreement in the ordinary course of business consistent with past practice, Buyer does not have any liabilities, commitments or obligations, asserted or unasserted, known or unknown, absolute or contingent, whether or not accrued, matured or un-matured or otherwise, of a nature required by GAAP to be reflected in a consolidated balance sheet or disclosed in the notes thereto.

        5.8    Absence of Certain Changes or Events.    Since the date of the financial statements included or incorporated by reference in Buyer's Quarterly Report on Form 10-Q for the quarter ended March 31, 2009 (the "Buyer Balance Sheet Date"), (a) no Effect has occurred which has had or would reasonably be expected to have, individually or in the aggregate, a Buyer Material Adverse Effect and (b) Buyer has not taken or omitted to take any action that would, if taken or omitted to be taken after the date hereof, result in a breach of Section 6.2 of this Agreement.

        5.9    Taxes.    The representations and warranties contained in this Section 5.9 are the only representations and warranties made by Buyer in this Agreement with respect to Tax matters. Except as would not reasonably be expected, individually or in the aggregate, to have a Buyer Material Adverse Effect:

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        5.10    Litigation.    As of the date hereof neither Buyer nor any of its Subsidiaries is a party to any, and there are no pending or, to Buyer's Knowledge, threatened, legal, administrative, arbitral or other material proceedings, claims, actions or governmental or regulatory investigations (a "Proceeding") of any nature against Buyer or any of its Subsidiaries, in each case that, individually or in the aggregate, would reasonably be expected to have a Buyer Material Adverse Effect. Neither Buyer, its Subsidiaries, nor any of their respective businesses or properties are subject to or bound by any injunction, order, judgment, decree or regulatory restriction of any Governmental Authority specifically imposed upon Buyer, its Subsidiaries or their respective properties or assets.

        5.11    Environmental.    (i) Buyer is in compliance in all material respects with all applicable Environmental Laws, and possesses and complies in all material respects with all applicable Environmental Permits required under such Laws to operate as it presently operates; (ii) there are no Materials of Environmental Concern at any property owned or operated by Buyer, under circumstances that are reasonably likely to result in a material liability of Buyer under any applicable Environmental Law; (iii) neither Buyer nor any of its Subsidiaries has received any written notification alleging that it is liable for, or request for information pursuant to section 104(e) of the Comprehensive Environmental Response, Compensation and Liability Act or similar state statute, concerning, any release or threatened release of Materials of Environmental Concern at any location except, with respect to any such notification or request for information concerning any such release or threatened release, to the extent such matter has been resolved with the appropriate foreign, federal, state or local regulatory authority or otherwise; and (iv) neither Buyer nor any of its Subsidiaries has received any written claim or complaint, or is subject to any proceeding, relating to material noncompliance with Environmental Laws or any other material liabilities pursuant to Environmental Laws, and no such matter has been threatened in writing to the Knowledge of Buyer.

        5.12    Intellectual Property; Software.    

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        5.13    FDA Regulatory Compliance.    

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        5.14    Suppliers And Manufacturers; Effect Of Transaction.    

        5.15    No Breach of Designated Contracts.    Neither Buyer nor any of its Subsidiaries has since January 1, 2008 received written notice of any breach of or default under any material contracts of Buyer and its Subsidiaries filed by Buyer with the SEC as exhibits to its Annual Report on Form 10-K for the fiscal year ended December 31, 2008, or incorporated by reference therein (each a "Buyer Designated Contract"), other than any breach or default that has been cured, waived or otherwise resolved in all material respects. To Buyer's Knowledge, no other party to a Buyer Designated Contract

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is in default of any of its obligations thereunder. Each Buyer Designated Contract is in full force and effect. Each Buyer Designated Contract is a legal, valid and binding obligation of Buyer or its Subsidiary and the other party thereto, except as to the legality, validity and binding nature thereof may be limited by bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium or other similar Laws now or hereafter in effect relating to creditors' rights and by general equitable principles (regardless of whether considered in a proceeding at law or equity).

        5.16    Finders' Fees.    No agent, broker, investment banker, financial advisor or other firm or Person other than WBB Securities, LLC and Brean Murray, Carret & Co., Inc., is or will be entitled to any broker's or finder's fee or any other similar commission or fee from Buyer in connection with any of the transactions contemplated by this Agreement.

        5.17    Opinion of Financial Advisor.    Buyer has received the opinion of Brean Murray, Carret & Co., Inc., dated May 28, 2009, to the effect that the Common Stock Exchange Ratio is fair, from a financial point of view, to Buyer, a copy of which opinion has been delivered to the Company or will be delivered to the Company promptly following the date of this Agreement.

        5.18    Merger Sub Operations.    

        5.19    Ownership of Company Common Stock.    Buyer does not, immediately prior to entering into this Agreement, beneficially own (within the meaning of Section 13 of the Exchange Act and the rules and regulations promulgated thereunder), or will prior to the Effective Time beneficially own any shares of Company Common Stock, and Buyer is not a party, or will prior to the Closing Date become a party, to any Contract, arrangement or understanding (other than this Agreement) for the purpose of acquiring, holding, voting or disposing of any shares of Company Common Stock, and Buyer has not within the last three years owned (within the meaning of Section 203 of the DGCL) 15% or more of the outstanding shares of Company Common Stock.

ARTICLE VI
CONDUCT OF BUSINESS PENDING THE MERGER

        6.1    Conduct of the Company.    Except for matters set forth in Section 6.1 of the Company Disclosure Letter or as otherwise contemplated by or specifically provided in this Agreement or as consented to in writing by Buyer, during the period commencing on the date of this Agreement and ending at the Effective Time or such earlier date as this Agreement may be terminated in accordance with its terms (the "Pre-Closing Period"), the Company shall (x) act and carry on its business in the ordinary course of business consistent with past practice, (y) comply with all applicable Laws and the requirements of all Material Contracts and Permits and make all voluntary disclosures deemed appropriate to Governmental Entities and (z) use commercially reasonable efforts to (i) maintain and preserve its business organization, assets and properties and preserve the goodwill of its business relationships with customers, strategic partners, suppliers, distributors and others having business dealings with it, (ii) retain the services of its current officers and key employees, and (iii) keep in full force and effect all insurance policies, other than changes to such policies made in the ordinary course of business consistent with past practice. Without limiting the generality of the foregoing, except as specifically set forth in the proviso immediately following Section 6.1(p) below, in Section 6.1 of the

39


Company Disclosure Letter or as otherwise contemplated by or specifically provided in this Agreement or as consented to in writing by Buyer, during the Pre-Closing Period the Company shall not do any of the following without the prior written consent of Buyer:

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provided, however, that nothing in this Section 6.1 shall prohibit the Company from amending the Convertible Notes and/or the terms of the Indenture as may be necessary to allow for the assumption of the Convertible Notes by Buyer pursuant to the Supplemental Indenture.

        6.2    Conduct of Buyer.    Except for matters set forth in Section 6.2 of Buyer Disclosure Letter or as otherwise contemplated by or specifically provided in this Agreement or as subsequently consented to in writing by the Company, during the Pre-Closing Period, Buyer shall use its reasonable best efforts to conduct its business in the ordinary and usual course consistent with past practice. Without limiting the generality of the foregoing, and except for matters set forth in Section 6.2 of the Buyer Disclosure Letter or as expressly contemplated or permitted by this Agreement, without the prior written consent of the Company, Buyer shall not, and shall not permit its Subsidiaries to:

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        6.3    No Control of Other Party's Business.    Nothing contained in this Agreement is intended to give Buyer, directly or indirectly, the right to control or direct the Company's operations during the Pre-Closing Period, and nothing contained in this Agreement is intended to give the Company, directly or indirectly, the right to control or direct Buyer's or its Subsidiaries' operations during the Pre-Closing Period.

ARTICLE VII
ADDITIONAL AGREEMENTS

        7.1    Stockholder Meetings; Joint Proxy Statement/Prospectus.    

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        7.2    Reasonable Best Efforts.    Subject to the terms and conditions of this Agreement, each party will use its reasonable best efforts to take, or cause to be taken, all actions, to file, or cause to be filed, all documents and to do, or cause to be done, all things necessary, proper or advisable to consummate the transactions contemplated by this Agreement, including (a) preparing and filing as promptly as practicable all documentation to effect all necessary filings, consents, waivers, approvals, authorizations, Permits or orders from all Governmental Authorities or other Persons, (b) defending any claim, investigation, action, suit or other legal proceeding, whether judicial or administrative, challenging this Agreement or the consummation of the transactions contemplated hereby; and (c) executing additional instruments necessary to consummate the transactions contemplated by this Agreement. Each party will promptly consult with the other and provide necessary information (including copies thereof) with respect to all filings made by such party with any Governmental Authority in connection with this Agreement and the transactions contemplated hereby.

        7.3    Access to Information.    

        7.4    Solicitation.    

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        7.5    Director and Officer Liability.    

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        7.6    Takeover Statutes.    The parties shall use their respective reasonable best efforts (i) to take all action necessary so that no state takeover statute is or becomes applicable to the Merger or any of the other transactions contemplated by this Agreement and (ii) if any such takeover statute is or becomes applicable to any of the foregoing, to take all action necessary so that the Merger and the other transactions contemplated by this Agreement may be consummated as promptly as practicable on the terms contemplated by this Agreement and otherwise to minimize the effect of such takeover statute on the Merger and the other transactions contemplated by this Agreement.

        7.7    Public Announcements.    Except with respect to (a) any Buyer Recommendation Withdrawal effected pursuant to, and in accordance with, Section 7.1(d) or any action pursuant to, and in accordance with, such section, (b) any Recommendation Withdrawal or any action taken pursuant to, and in accordance with, Section 7.4 or (c) any action taken pursuant to, and in accordance with, Article IX, so long as this Agreement is in effect, the parties will consult with each other before issuing any press release or making any public statement with respect to this Agreement or the transactions contemplated hereby and, except for any press release or public statement as may be required by applicable Law or the rules and regulations of NASDAQ with respect to which it is impossible without undue effort or expense to consult with the other parties, will not issue any such press release or make any such public statement without the consent of the other parties (not to be unreasonably withheld or delayed).

        7.8    Notice of Certain Events.    From and after the date of this Agreement until the Effective Time, the Company and Buyer shall promptly notify each other orally and in writing of (i) the inaccuracy in any material respect of any representation or warranty contained in this Agreement, (ii) the failure of such party to comply with or satisfy any covenant, condition or agreement to be complied with or satisfied by it pursuant to this Agreement which, individually or in the aggregate, would reasonably be expected to result in any condition to the obligations of any party to effect the Merger and the other transactions contemplated by this Agreement not to be satisfied, (iii) any actions, suits, claims, investigations or proceedings commenced or, to its Knowledge, threatened against or involving or otherwise affecting the Company or Buyer that, if pending on the date of this Agreement, would have been required to have been disclosed pursuant to this Agreement or that relate to the consummation

50



of the transactions contemplated by this Agreement, (iv) any communication from any Governmental Entity in connection with the transactions contemplated by this Agreement (and the response thereto from the Company) and (v) any communication from any Person alleging that the consent of such Person (or another Person) is or may be required in connection with the transactions contemplated by this Agreement (and the response thereto from the Company); provided, however, that the delivery of any notice pursuant to this Section 7.8 shall not cure any breach of any representation or warranty requiring disclosure of such matter prior to the date of this Agreement or otherwise limit or affect the remedies available hereunder to the party receiving such notice. With respect to any of the foregoing, the Company will consult with Buyer and its Representatives so as to permit the Company and Buyer and their respective Representatives to cooperate to take appropriate measures to avoid or mitigate any adverse consequences that may result from any of the foregoing.

        7.9    Employee Matters.    

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        7.10    Listing.    Buyer shall use its reasonable best efforts to maintain its existing listing on NASDAQ and to cause the shares of Buyer Common Stock being issued pursuant to the Merger or issuable upon exercise of Company Options assumed by Buyer in connection with the Merger to be approved for listing (subject to notice of issuance) on NASDAQ at or prior to the Effective Time.

        7.11    Tax Matters.    

        7.12    Stockholder Litigation.    Each of the Company and Buyer shall give the other party the opportunity to participate in the defense or settlement of any litigation against such party and/or its directors relating to the transactions contemplated by this Agreement, and no such settlement shall be agreed to without the other party's prior written consent, not to be unreasonably withheld or delayed.

        7.13    Exemption from Liability Under Section 16(b).    

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        7.14    Board of Directors of Buyer.    Prior to the Effective Time, Buyer shall cause, effective immediately following the Effective Time, the number of members of the Board of Directors of Buyer to be fixed at nine (9) and the person identified on Schedule 7.14 to be appointed to the Board of Directors of Buyer. If the person designated to be a director on Schedule 7.14 shall prior to the Effective Time be unable or unwilling to hold office immediately after the Effective Time, the Company and Buyer shall work together in good faith to designate another person acceptable to Buyer as a director in his or her place.

ARTICLE VIII
CONDITIONS TO THE MERGER

        8.1    Conditions to the Obligations of Each Party.    The obligations of the Company, Merger Sub and Buyer to consummate the Merger are subject to the satisfaction of the following conditions:

        8.2    Conditions to the Obligations of Buyer and Merger Sub.    The obligations of Buyer and Merger Sub to consummate the Merger are subject to the satisfaction or valid waiver of the following further conditions:

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        8.3    Conditions to the Obligations of the Company.    The obligation of the Company to consummate the Merger is subject to the satisfaction or valid waiver of the following further conditions:

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ARTICLE IX
TERMINATION

        9.1    Termination.    This Agreement may be terminated and the Merger may be abandoned at any time prior to the Effective Time (notwithstanding any prior adoption of this Agreement by the stockholders of the Company):

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        9.2    Termination Fee.    

        9.3    Effect of Termination.    If this Agreement is terminated pursuant to Section 9. 1, this Agreement shall forthwith become null and void and there shall be no liability or obligation on the part of the Company, Buyer, Merger Sub or their respective Subsidiaries or Affiliates, except that the provisions of Sections 7.3(c), 9.2, 9.3 and Article X will survive the termination hereof; provided, however, that nothing herein shall relieve any party from liability for willful breach or fraud.

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ARTICLE X
MISCELLANEOUS

        10.1    Notices.    All notices, requests and other communications to any party hereunder shall be in writing (including facsimile or similar writing) and shall be given:

or such other address or facsimile number as such party may hereafter specify by notice to the other parties hereto. Each such notice, request or other communication shall be effective (i) if given by telecopier, when such telecopy is transmitted to the facsimile number specified above and electronic confirmation of transmission is received or (ii) if given by any other means, when delivered at the address specified in this Section 10.1.

        10.2    Representations and Warranties.    None of the representations, warranties, covenants and agreements in this Agreement or in any instrument delivered pursuant to this Agreement shall survive the Effective Time, except for those covenants and agreements contained herein and therein which by their terms apply in whole or in part after the Effective Time and then only to such extent. Each of the Company, Merger Sub and Buyer acknowledges and agrees that, except for the representations and warranties expressly set forth in this Agreement (a) no party makes, and has not made, any representations or warranties relating to itself or its businesses or otherwise in connection with the Merger, (b) no person has been authorized by any party to make any representation or warranty relating to itself or its businesses or otherwise in connection with the Merger and, if made, such representation or warranty must not be relied upon as having been authorized by such party, and (c) any estimates, projections, predictions, data, financial information, memoranda, presentations or any other materials or information provided or addressed to any party or any of its Representatives are not

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and shall not be deemed to be or to include representations or warranties unless any such materials or information are expressly the subject of any representation or warranty set forth in this Agreement.

        10.3    Expenses.    Except as otherwise expressly provided in Sections 7.5 and 9.2, all costs and expenses incurred in connection with this Agreement shall be paid by the party incurring such cost or expense.

        10.4    Amendment.    This Agreement may be amended by the parties hereto by action taken by or on behalf of their respective Boards of Directors or Board of Managers, as applicable, at any time prior to the Effective Time, whether before or after adoption of this Agreement by the stockholders of the Company; provided, however, that, after adoption of this Agreement by the stockholders of the Company, no amendment may be made which under applicable Law requires the further approval of the stockholders of the Company without such further approval. This Agreement may not be amended except by an instrument in writing signed by the parties hereto.

        10.5    Waiver.    At any time prior to the Effective Time, any party hereto may (i) extend the time for the performance of any of the obligations or other acts of the other parties hereto, (ii) waive any inaccuracies in the representations and warranties contained herein or in any document delivered pursuant hereto and (iii) subject to the requirements of applicable Law, waive compliance with any of the agreements or conditions contained for the benefit of such party contained herein. Any such extension or waiver shall be valid if set forth in an instrument in writing signed by the party or parties to be bound thereby. The failure of any party to assert any rights or remedies shall not constitute a waiver of such rights or remedies.

        10.6    Successors and Assigns.    The provisions of this Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns, provided that no party may assign, delegate or otherwise transfer any of its rights or obligations under this Agreement without the consent of the other parties hereto (and any purported assignment without such consent shall be void and without effect).

        10.7    Governing Law.    This Agreement shall be governed by and construed in accordance with the Laws of the State of Delaware (without regard to conflict of Laws principles).

        10.8    Counterparts; Effectiveness; Third Party Beneficiaries.    This Agreement may be executed by facsimile signatures and in any number of counterparts, each of which shall be an original, with the same effect as if the signatures thereto and hereto were upon the same instrument. This Agreement shall become effective only when actually signed by each party hereto and each such party has received counterparts hereof signed by all of the other parties hereto. No provision of this Agreement is intended to or shall confer upon any Person other than the parties hereto any rights or remedies hereunder or with respect hereto, except as otherwise expressly provided in Section 7.5 (which is intended to be for the benefit of the persons covered thereby).

        10.9    Severability.    If any term or other provision of this Agreement is invalid, illegal or incapable of being enforced by virtue of any Law, or due to any public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner so that the transactions contemplated hereby are fulfilled to the extent possible.

        10.10    Entire Agreement.    This Agreement (including the exhibits and schedules thereto) constitutes the entire agreement of the parties hereto with respect to its subject matter and supersedes all oral or written prior or contemporaneous agreements and understandings among the parties with respect to such subject matter.

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        10.11    Remedies.    The parties hereto agree that irreparable damage would occur in the event that any provision of this Agreement were not performed in accordance with its specific terms or were otherwise breached. It is accordingly agreed that the parties shall be entitled to an injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement, in addition to any other remedy they may have at law or in equity.

        10.12    Jurisdiction.    

        10.13    Headings.    The headings contained in this Agreement are for convenience of reference only, shall not be deemed to be a part of this Agreement and shall not be referred to in connection with the construction or interpretation of this Agreement.

        10.14    Further Assurances.    Each party will, and will cause its Subsidiaries to, execute such further documents and instruments and take such further actions as may reasonably be requested by any other party in order to consummate the Merger in accordance with the terms hereof.

        10.15    Authorship.    The parties agree that the terms and language of this Agreement were the result of negotiations between the parties and their respective advisors and, as a result, there shall be no presumption that any ambiguities in this Agreement shall be resolved against any party. Any controversy over construction of this Agreement shall be decided without regard to events of authorship or negotiation.

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        IN WITNESS WHEREOF, the parties hereto have caused this Agreement and Plan of Merger to be duly executed by their respective authorized officers as of the day and year first written above.

    CELLDEX THERAPEUTICS, INC.

 

 

By:

 

/s/ Anthony S. Marucci

    Its:   President and Chief Executive Officer


 

 

COTTRELL MERGER SUB, INC.

 

 

By:

 

/s/ Anthony S. Marucci

    Its:   President


 

 

CURAGEN CORPORATION

 

 

By:

 

/s/ Timothy Shannon

    Its:   President and Chief Executive Officer


EXHIBIT A

FORM OF CERTIFICATE OF INCORPORATION
OF
SURVIVING CORPORATION

CERTIFICATE OF INCORPORATION
OF
[    •    ]

        FIRST. The name of the corporation is [    •    ]

        SECOND. The address of its registered office in the State of Delaware is Corporation Service Company, 2711 Centerville Road, Suite 400, City of Wilmington, County of New Castle, Delaware 19808. The name of its registered agent at such address is Corporation Service Company.

        THIRD. The purpose of the corporation is to engage in any lawful act or activity for which corporations may be organized under the General Corporation Law of the State of Delaware.

        FOURTH. The total number of shares of stock which the corporation shall have authority to issue is 1,000. All such shares are to be Common Stock, par value of $.01 per share, and are to be of one class.

        FIFTH. The incorporator of the corporation is Eric J. Weiner, whose mailing address is c/o Lowenstein Sandler PC, 65 Livingston Avenue, Roseland, New Jersey 07068.

        SIXTH. Unless and except to the extent that the bylaws of the corporation shall so require, the election of directors of the corporation need not be by written ballot.

        SEVENTH. In furtherance and not in limitation of the powers conferred by the laws of the State of Delaware, the Board of Directors of the corporation is expressly authorized to make, alter and repeal the bylaws of the corporation.

        EIGHTH. A director of the corporation shall not be liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except to the extent such exemption from liability or limitation thereof is not permitted under the General Corporation Law of the State of Delaware as the same exists or may hereafter be amended. Any amendment, modification or repeal of the foregoing sentence shall not adversely affect any right or protection of a director of the corporation hereunder in respect of any act or omission occurring prior to the time of such amendment, modification or repeal.

        NINTH. The corporation reserves the right at any time, and from time to time, to amend, alter, change or repeal any provision contained in this Certificate of Incorporation, and other provisions authorized by the laws of the State of Delaware at the time in force may be added or inserted, in the manner now or hereafter prescribed by law; and all rights, preferences and privileges of any nature conferred upon stockholders, directors or any other persons by and pursuant to this Certificate of Incorporation in its present form or as hereafter amended are granted subject to the rights reserved in this article.

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EXHIBIT B

FORM OF BY-LAWS
OF
SURVIVING CORPORATION

BYLAWS
OF
[    •    ]

ARTICLE I
Meetings of Stockholders

        Section 1.1.    Annual Meetings.    If required by applicable law, an annual meeting of stockholders shall be held for the election of directors at such date, time and place, if any, either within or without the State of Delaware, as may be designated by resolution of the Board of Directors from time to time. Any other proper business may be transacted at the annual meeting.

        Section 1.2.    Special Meetings.    Special meetings of stockholders for any purpose or purposes may be called at any time by the Board of Directors, but such special meetings may not be called by any other person or persons. Business transacted at any special meeting of stockholders shall be limited to the purposes stated in the notice.

        Section 1.3.    Notice of Meetings.    Whenever stockholders are required or permitted to take any action at a meeting, a notice of the meeting shall be given that shall state the place, if any, date and hour of the meeting and, in the case of a special meeting, the purpose or purposes for which the meeting is called. Unless otherwise provided by law, the certificate of incorporation or these bylaws, the notice of any meeting shall be given not less than ten (10) nor more than sixty (60) days before the date of the meeting to each stockholder entitled to vote at such meeting. If mailed, such notice shall be deemed to be given when deposited in the United States mail, postage prepaid, directed to the stockholder at such stockholder's address as it appears on the records of the corporation.

        Section 1.4.    Adjournments.    Any meeting of stockholders, annual or special, may adjourn from time to time to reconvene at the same or some other place, and notice need not be given of any such adjourned meeting if the time and place thereof are announced at the meeting at which the adjournment is taken. At the adjourned meeting the corporation may transact any business which might have been transacted at the original meeting. If the adjournment is for more than thirty (30) days, or if after the adjournment a new record date is fixed for the adjourned meeting, notice of the adjourned meeting shall be given to each stockholder of record entitled to vote at the meeting.

        Section 1.5.    Quorum.    Except as otherwise provided by law, the certificate of incorporation or these bylaws, at each meeting of stockholders the presence in person or by proxy of the holders of a majority in voting power of the outstanding shares of stock entitled to vote at the meeting shall be necessary and sufficient to constitute a quorum. In the absence of a quorum, the stockholders so present may, by a majority in voting power thereof, adjourn the meeting from time to time in the manner provided in Section 1.4 of these bylaws until a quorum shall attend. Shares of its own stock belonging to the corporation or to another corporation, if a majority of the shares entitled to vote in the election of directors of such other corporation is held, directly or indirectly, by the corporation, shall neither be entitled to vote nor be counted for quorum purposes; provided, however, that the foregoing shall not limit the right of the corporation or any subsidiary of the corporation to vote stock, including but not limited to its own stock, held by it in a fiduciary capacity.

        Section 1.6.    Organization.    Meetings of stockholders shall be presided over by the Chairperson of the Board, if any, or in his or her absence by the Vice Chairperson of the Board, if any, or in his or

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her absence by the President, or in his or her absence by a Vice President, or in the absence of the foregoing persons by a chairperson designated by the Board of Directors, or in the absence of such designation by a chairperson chosen at the meeting. The Secretary shall act as secretary of the meeting, but in his or her absence the chairperson of the meeting may appoint any person to act as secretary of the meeting.

        Section 1.7.    Voting; Proxies.    Except as otherwise provided by or pursuant to the provisions of the certificate of incorporation, each stockholder entitled to vote at any meeting of stockholders shall be entitled to one vote for each share of stock held by such stockholder which has voting power upon the matter in question. Each stockholder entitled to vote at a meeting of stockholders or to express consent to corporate action in writing without a meeting may authorize another person or persons to act for such stockholder by proxy, but no such proxy shall be voted or acted upon after three years from its date, unless the proxy provides for a longer period. A proxy shall be irrevocable if it states that it is irrevocable and if, and only as long as, it is coupled with an interest sufficient in law to support an irrevocable power. A stockholder may revoke any proxy which is not irrevocable by attending the meeting and voting in person or by delivering to the Secretary of the corporation a revocation of the proxy or a new proxy bearing a later date. Voting at meetings of stockholders need not be by written ballot. At all meetings of stockholders for the election of directors at which a quorum is present a plurality of the votes cast shall be sufficient to elect. All other elections and questions presented to the stockholders at a meeting at which a quorum is present shall, unless otherwise provided by the certificate of incorporation, these bylaws, the rules or regulations of any stock exchange applicable to the corporation, or applicable law or pursuant to any regulation applicable to the corporation or its securities, be decided by the affirmative vote of the holders of a majority in voting power of the shares of stock of the corporation which are present in person or by proxy and entitled to vote thereon.

        Section 1.8.    Fixing Date for Determination of Stockholders of Record.    In order that the corporation may determine the stockholders entitled to notice of or to vote at any meeting of stockholders or any adjournment thereof, or to express consent to corporate action in writing without a meeting, or entitled to receive payment of any dividend or other distribution or allotment of any rights, or entitled to exercise any rights in respect of any change, conversion or exchange of stock or for the purpose of any other lawful action, the Board of Directors may fix a record date, which record date shall not precede the date upon which the resolution fixing the record date is adopted by the Board of Directors, and which record date: (1) in the case of determination of stockholders entitled to vote at any meeting of stockholders or adjournment thereof, shall, unless otherwise required by law, not be more than sixty (60) nor less than ten (10) days before the date of such meeting; (2) in the case of determination of stockholders entitled to express consent to corporate action in writing without a meeting, shall not be more than ten (10) days from the date upon which the resolution fixing the record date is adopted by the Board of Directors; and (3) in the case of any other action, shall not be more than sixty (60) days prior to such other action. If no record date is fixed: (1) the record date for determining stockholders entitled to notice of or to vote at a meeting of stockholders shall be at the close of business on the day next preceding the day on which notice is given, or, if notice is waived, at the close of business on the day next preceding the day on which the meeting is held; (2) the record date for determining stockholders entitled to express consent to corporate action in writing without a meeting, when no prior action of the Board of Directors is required by law, shall be the first date on which a signed written consent setting forth the action taken or proposed to be taken is delivered to the corporation in accordance with applicable law, or, if prior action by the Board of Directors is required by law, shall be at the close of business on the day on which the Board of Directors adopts the resolution taking such prior action; and (3) the record date for determining stockholders for any other purpose shall be at the close of business on the day on which the Board of Directors adopts the resolution relating thereto. A determination of stockholders of record entitled to notice of or to vote at a meeting of stockholders shall apply to any adjournment of the meeting; provided, however, that the Board of Directors may fix a new record date for the adjourned meeting.

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        Section 1.9.    List of Stockholders Entitled to Vote.    The officer who has charge of the stock ledger shall prepare and make, at least ten (10) days before every meeting of stockholders, a complete list of the stockholders entitled to vote at the meeting, arranged in alphabetical order, and showing the address of each stockholder and the number of shares registered in the name of each stockholder. Such list shall be open to the examination of any stockholder, for any purpose germane to the meeting at least ten (10) days prior to the meeting (i) on a reasonably accessible electronic network, provided that the information required to gain access to such list is provided with the notice of meeting or (ii) during ordinary business hours at the principal place of business of the corporation. The list of stockholders must also be open to examination at the meeting as required by applicable law. Except as otherwise provided by law, the stock ledger shall be the only evidence as to who are the stockholders entitled to examine the list of stockholders required by this Section 1.9 or to vote in person or by proxy at any meeting of stockholders.

        Section 1.10.    Action By Written Consent of Stockholders.    Unless otherwise restricted by the certificate of incorporation, any action required or permitted to be taken at any annual or special meeting of the stockholders may be taken without a meeting, without prior notice and without a vote, if a consent or consents in writing, setting forth the action so taken, shall be signed by the holders of outstanding stock having not less than the minimum number of votes that would be necessary to authorize or take such action at a meeting at which all shares entitled to vote thereon were present and voted and shall be delivered to the corporation by delivery to its registered office in the State of Delaware, its principal place of business, or an officer or agent of the corporation having custody of the book in which minutes of proceedings of stockholders are recorded. Delivery made to the corporation's registered office shall be by hand or by certified or registered mail, return receipt requested. Prompt notice of the taking of the corporate action without a meeting by less than unanimous written consent shall, to the extent required by law, be given to those stockholders who have not consented in writing and who, if the action had been taken at a meeting, would have been entitled to notice of the meeting if the record date for such meeting had been the date that written consents signed by a sufficient number of holders to take the action were delivered to the corporation.

        Section 1.11.    Inspectors of Election.    The corporation may, and shall if required by law, in advance of any meeting of stockholders, appoint one or more inspectors of election, who may be employees of the corporation, to act at the meeting or any adjournment thereof and to make a written report thereof. The corporation may designate one or more persons as alternate inspectors to replace any inspector who fails to act. In the event that no inspector so appointed or designated is able to act at a meeting of stockholders, the person presiding at the meeting shall appoint one or more inspectors to act at the meeting. Each inspector, before entering upon the discharge of his or her duties, shall take and sign an oath to execute faithfully the duties of inspector with strict impartiality and according to the best of his or her ability. The inspector or inspectors so appointed or designated shall (i) ascertain the number of shares of capital stock of the corporation outstanding and the voting power of each such share, (ii) determine the shares of capital stock of the corporation represented at the meeting and the validity of proxies and ballots, (iii) count all votes and ballots, (iv) determine and retain for a reasonable period a record of the disposition of any challenges made to any determination by the inspectors, and (v) certify their determination of the number of shares of capital stock of the corporation represented at the meeting and such inspectors' count of all votes and ballots. Such certification and report shall specify such other information as may be required by law. In determining the validity and counting of proxies and ballots cast at any meeting of stockholders of the corporation, the inspectors may consider such information as is permitted by applicable law. No person who is a candidate for an office at an election may serve as an inspector at such election.

        Section 1.12.    Conduct of Meetings.    The date and time of the opening and the closing of the polls for each matter upon which the stockholders will vote at a meeting shall be announced at the meeting by the person presiding over the meeting. The Board of Directors may adopt by resolution such rules

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and regulations for the conduct of the meeting of stockholders as it shall deem appropriate. Except to the extent inconsistent with such rules and regulations as adopted by the Board of Directors, the person presiding over any meeting of stockholders shall have the right and authority to convene and to adjourn the meeting, to prescribe such rules, regulations and procedures and to do all such acts as, in the judgment of such presiding person, are appropriate for the proper conduct of the meeting. Such rules, regulations or procedures, whether adopted by the Board of Directors or prescribed by the presiding person of the meeting, may include, without limitation, the following: (i) the establishment of an agenda or order of business for the meeting; (ii) rules and procedures for maintaining order at the meeting and the safety of those present; (iii) limitations on attendance at or participation in the meeting to stockholders of record of the corporation, their duly authorized and constituted proxies or such other persons as the presiding person of the meeting shall determine; (iv) restrictions on entry to the meeting after the time fixed for the commencement thereof; and (v) limitations on the time allotted to questions or comments by participants. The presiding person at any meeting of stockholders, in addition to making any other determinations that may be appropriate to the conduct of the meeting, shall, if the facts warrant, determine and declare to the meeting that a matter or business was not properly brought before the meeting and if such presiding person should so determine, such presiding person shall so declare to the meeting and any such matter or business not properly brought before the meeting shall not be transacted or considered. Unless and to the extent determined by the Board of Directors or the person presiding over the meeting, meetings of stockholders shall not be required to be held in accordance with the rules of parliamentary procedure.

ARTICLE II
Board of Directors

        Section 2.1.    Number; Qualifications.    The Board of Directors shall consist of one or more members, the number thereof to be determined from time to time by resolution of the Board of Directors. Directors need not be stockholders.

        Section 2.2.    Election; Resignation; Vacancies.    The Board of Directors shall initially consist of the persons named as directors in the certificate of incorporation or elected by the incorporator of the corporation, and each director so elected shall hold office until the first annual meeting of stockholders or until his or her successor is duly elected and qualified. At the first annual meeting of stockholders and at each annual meeting thereafter, the stockholders shall elect directors each of whom shall hold office for a term of one year or until his or her successor is duly elected and qualified, subject to such director's earlier death, resignation, disqualification or removal. Any director may resign at any time upon notice to the corporation. Unless otherwise provided by law or the certificate of incorporation, any newly created directorship or any vacancy occurring in the Board of Directors for any cause may be filled by a majority of the remaining members of the Board of Directors, although such majority is less than a quorum, or by a plurality of the votes cast at a meeting of stockholders, and each director so elected shall hold office until the expiration of the term of office of the director whom he or she has replaced or until his or her successor is elected and qualified.

        Section 2.3.    Regular Meetings.    Regular meetings of the Board of Directors may be held at such places within or without the State of Delaware and at such times as the Board of Directors may from time to time determine.

        Section 2.4.    Special Meetings.    Special meetings of the Board of Directors may be held at any time or place within or without the State of Delaware whenever called by the President, any Vice President, the Secretary, or by any member of the Board of Directors. Notice of a special meeting of the Board of Directors shall be given by the person or persons calling the meeting at least twenty-four hours before the special meeting.

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        Section 2.5.    Telephonic Meetings Permitted.    Members of the Board of Directors, or any committee designated by the Board of Directors, may participate in a meeting thereof by means of conference telephone or other communications equipment by means of which all persons participating in the meeting can hear each other, and participation in a meeting pursuant to this by-law shall constitute presence in person at such meeting.

        Section 2.6.    Quorum; Vote Required for Action.    At all meetings of the Board of Directors the directors entitled to cast a majority of the votes of the whole Board of Directors shall constitute a quorum for the transaction of business. Except in cases in which the certificate of incorporation, these bylaws or applicable law otherwise provides, a majority of the votes entitled to be cast by the directors present at a meeting at which a quorum is present shall be the act of the Board of Directors.

        Section 2.7.    Organization.    Meetings of the Board of Directors shall be presided over by the Chairperson of the Board, if any, or in his or her absence by the Vice Chairperson of the Board, if any, or in his or her absence by the President, or in their absence by a chairperson chosen at the meeting. The Secretary shall act as secretary of the meeting, but in his or her absence the chairperson of the meeting may appoint any person to act as secretary of the meeting.

        Section 2.8.    Action by Unanimous Consent of Directors.    Unless otherwise restricted by the certificate of incorporation or these bylaws, any action required or permitted to be taken at any meeting of the Board of Directors, or of any committee thereof, may be taken without a meeting if all members of the Board of Directors or such committee, as the case may be, consent thereto in writing or by electronic transmission and the writing or writings or electronic transmissions are filed with the minutes of proceedings of the board or committee in accordance with applicable law.

ARTICLE III
Committees

        Section 3.1.    Committees.    The Board of Directors may designate one or more committees, each committee to consist of one or more of the directors of the corporation. The Board of Directors may designate one or more directors as alternate members of any committee, who may replace any absent or disqualified member at any meeting of the committee. In the absence or disqualification of a member of the committee, the member or members thereof present at any meeting and not disqualified from voting, whether or not he, she or they constitute a quorum, may unanimously appoint another member of the Board of Directors to act at the meeting in place of any such absent or disqualified member. Any such committee, to the extent permitted by law and to the extent provided in the resolution of the Board of Directors, shall have and may exercise all the powers and authority of the Board of Directors in the management of the business and affairs of the corporation, and may authorize the seal of the corporation to be affixed to all papers which may require it.

        Section 3.2.    Committee Rules.    Unless the Board of Directors otherwise provides, each committee designated by the Board of Directors may make, alter and repeal rules for the conduct of its business. In the absence of such rules each committee shall conduct its business in the same manner as the Board of Directors conducts its business pursuant to Article II of these bylaws.

ARTICLE IV
Officers

        Section 4.1.    Officers; Election; Qualifications; Term of Office; Resignation; Removal; Vacancies.    The Board of Directors shall elect a President and Secretary, and it may, if it so determines, choose a Chairperson of the Board and a Vice Chairperson of the Board from among its members. The Board of Directors may also choose one or more Vice Presidents, one or more Assistant Secretaries, a Treasurer and one or more Assistant Treasurers and such other officers as it shall from time to time deem necessary or desirable. Each such officer shall hold office until the first meeting of the Board of

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Directors after the annual meeting of stockholders next succeeding his or her election, and until his or her successor is elected and qualified or until his or her earlier resignation or removal. Any officer may resign at any time upon written notice to the corporation. The Board of Directors may remove any officer with or without cause at any time, but such removal shall be without prejudice to the contractual rights of such officer, if any, with the corporation. Any number of offices may be held by the same person. Any vacancy occurring in any office of the corporation by death, resignation, removal or otherwise may be filled for the unexpired portion of the term by the Board of Directors at any regular or special meeting.

        Section 4.2.    Powers and Duties of Officers.    The officers of the corporation shall have such powers and duties in the management of the corporation as may be prescribed in a resolution by the Board of Directors and, to the extent not so provided, as generally pertain to their respective offices, subject to the control of the Board of Directors. The Board of Directors may require any officer, agent or employee to give security for the faithful performance of his or her duties.

        Section 4.3.    Appointing Attorneys and Agents; Voting Securities of Other Entities.    Unless otherwise provided by resolution adopted by the Board of Directors, the Chairperson of the Board, the President or any Vice President may from time to time appoint an attorney or attorneys or agent or agents of the corporation, in the name and on behalf of the corporation, to cast the votes which the corporation may be entitled to cast as the holder of stock or other securities in any other corporation or other entity, any of whose stock or other securities may be held by the corporation, at meetings of the holders of the stock or other securities of such other corporation or other entity, or to consent in writing, in the name of the corporation as such holder, to any action by such other corporation or other entity, and may instruct the person or persons so appointed as to the manner of casting such votes or giving such consents, and may execute or cause to be executed in the name and on behalf of the corporation and under its corporate seal or otherwise, all such written proxies or other instruments as he or she may deem necessary or proper. Any of the rights set forth in this Section 4.3 which may be delegated to an attorney or agent may also be exercised directly by the Chairperson of the Board, the President or the Vice President.

ARTICLE V
Stock

        Section 5.1.    Certificates.    The shares of the corporation shall be represented by certificates, provided that the Board of Directors may provide by resolution or resolutions that some or all of any or all classes or series of stock shall be uncertificated shares. Any such resolution shall not apply to shares represented by a certificate until such certificate is surrendered to the corporation. Every holder of stock represented by certificates shall be entitled to have a certificate signed by or in the name of the corporation by the Chairperson or Vice Chairperson of the Board of Directors, if any, or the President or a Vice President, and by the Treasurer or an Assistant Treasurer, or the Secretary or an Assistant Secretary, of the corporation certifying the number of shares owned by such holder in the corporation. Any of or all the signatures on the certificate may be a facsimile. In case any officer, transfer agent or registrar who has signed or whose facsimile signature has been placed upon a certificate shall have ceased to be such officer, transfer agent, or registrar before such certificate is issued, it may be issued by the corporation with the same effect as if such person were such officer, transfer agent, or registrar at the date of issue.

        Section 5.2.    Lost, Stolen or Destroyed Stock Certificates; Issuance of New Certificates.    The corporation may issue a new certificate of stock in the place of any certificate theretofore issued by it, alleged to have been lost, stolen or destroyed, and the corporation may require the owner of the lost, stolen or destroyed certificate, or such owner's legal representative, to give the corporation a bond sufficient to indemnify it against any claim that may be made against it on account of the alleged loss, theft or destruction of any such certificate or the issuance of such new certificate.

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ARTICLE VI
Indemnification and Advancement of Expenses

        Section 6.1.    Right to Indemnification.    The corporation shall indemnify and hold harmless, to the fullest extent permitted by applicable law as it presently exists or may hereafter be amended, any person (a "Covered Person") who was or is made or is threatened to be made a party or is otherwise involved in any action, suit or proceeding, whether civil, criminal, administrative or investigative (a "proceeding"), by reason of the fact that he or she, or a person for whom he or she is the legal representative, is or was a director or officer of the corporation or, while a director or officer of the corporation, is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation or of a partnership, joint venture, trust, enterprise or nonprofit entity, including service with respect to employee benefit plans, against all liability and loss suffered and expenses (including attorneys' fees) reasonably incurred by such Covered Person. Notwithstanding the preceding sentence, except as otherwise provided in Section 6.3, the corporation shall be required to indemnify a Covered Person in connection with a proceeding (or part thereof) commenced by such Covered Person only if the commencement of such proceeding (or part thereof) by the Covered Person was authorized in the specific case by the Board of Directors of the corporation.

        Section 6.2.    Prepayment of Expenses.    The corporation shall to the fullest extent not prohibited by applicable law pay the expenses (including attorneys' fees) incurred by a Covered Person in defending any proceeding in advance of its final disposition, provided, however, that, to the extent required by law, such payment of expenses in advance of the final disposition of the proceeding shall be made only upon receipt of an undertaking by the Covered Person to repay all amounts advanced if it should be ultimately determined that the Covered Person is not entitled to be indemnified under this Article VI or otherwise.

        Section 6.3.    Claims.    If a claim for indemnification (following the final disposition of such action, suit or proceeding) or advancement of expenses under this Article VI is not paid in full within thirty days after a written claim therefor by the Covered Person has been received by the corporation, the Covered Person may file suit to recover the unpaid amount of such claim and, if successful in whole or in part, shall be entitled to be paid the expense of prosecuting such claim to the fullest extent permitted by law. In any such action the corporation shall have the burden of proving that the Covered Person is not entitled to the requested indemnification or advancement of expenses under applicable law.

        Section 6.4.    Nonexclusivity of Rights.    The rights conferred on any Covered Person by this Article VI shall not be exclusive of any other rights which such Covered Person may have or hereafter acquire under any statute, provision of the certificate of incorporation, these bylaws, agreement, vote of stockholders or disinterested directors or otherwise.

        Section 6.5.    Other Sources.    The corporation's obligation, if any, to indemnify or to advance expenses to any Covered Person who was or is serving at its request as a director, officer, employee or agent of another corporation, partnership, joint venture, trust, enterprise or nonprofit entity shall be reduced by any amount such Covered Person may collect as indemnification or advancement of expenses from such other corporation, partnership, joint venture, trust, enterprise or non-profit enterprise.

        Section 6.6.    Amendment or Repeal.    Any repeal or modification of the foregoing provisions of this Article VI shall not adversely affect any right or protection hereunder of any Covered Person in respect of any act or omission occurring prior to the time of such repeal or modification.

        Section 6.7.    Other Indemnification and Prepayment of Expenses.    This Article VI shall not limit the right of the corporation, to the extent and in the manner permitted by law, to indemnify and to

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advance expenses to persons other than Covered Persons when and as authorized by appropriate corporate action.

ARTICLE VII
Miscellaneous

        Section 7.1.    Fiscal Year.    The fiscal year of the corporation shall be determined by resolution of the Board of Directors.

        Section 7.2.    Seal.    The corporate seal shall have the name of the corporation inscribed thereon and shall be in such form as may be approved from time to time by the Board of Directors.

        Section 7.3.    Manner of Notice.    Except as otherwise provided herein or permitted by applicable law, notices to directors and stockholders shall be in writing and delivered personally or mailed to the directors or stockholders at their addresses appearing on the books of the corporation. Without limiting the manner by which notice otherwise may be given effectively to stockholders, and except as prohibited by applicable law, any notice to stockholders given by the corporation under any provision of applicable law, the certificate of incorporation, or these bylaws shall be effective if given by a single written notice to stockholders who share an address if consented to by the stockholders at that address to whom such notice is given. Any such consent shall be revocable by the stockholder by written notice to the corporation. Any stockholder who fails to object in writing to the corporation, within 60 days of having been given written notice by the corporation of its intention to send the single notice permitted under this Section 7.3, shall be deemed to have consented to receiving such single written notice. Notice to directors may be given by telecopier, telephone or other means of electronic transmission.

        Section 7.4.    Waiver of Notice of Meetings of Stockholders, Directors and Committees.    Any waiver of notice, given by the person entitled to notice, whether before or after the time stated therein, shall be deemed equivalent to notice. Attendance of a person at a meeting shall constitute a waiver of notice of such meeting, except when the person attends a meeting for the express purpose of objecting, at the beginning of the meeting, to the transaction of any business because the meeting is not lawfully called or convened. Neither the business to be transacted at nor the purpose of any regular or special meeting of the stockholders, directors, or members of a committee of directors need be specified in a waiver of notice.

        Section 7.5.    Form of Records.    Any records maintained by the corporation in the regular course of its business, including its stock ledger, books of account, and minute books, may be kept on, or by means of, or be in the form of, any information storage device or method, provided that the records so kept can be converted into clearly legible paper form within a reasonable time.

        Section 7.6.    Amendment of By-Laws.    These bylaws may be altered, amended or repealed, and new bylaws made, by the Board of Directors, but the stockholders may make additional bylaws and may alter and repeal any bylaws whether adopted by them or otherwise.

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QuickLinks


Exhibit 99.1

 

GRAPHIC

 

Celldex Therapeutics, Inc. Enhances Precision Targeted Immunotherapy Platform with the Acquisition of CuraGen Corporation

 

—Conference call scheduled for Friday, May 29, 2009 at 8:30 AM ET—

 

·                  Transaction adds 11 oncology-focused antibodies, including CR011, to expand Celldex’s Precision Targeted Immunotherapy Platform

·                  Increases potential value of both CuraGen and Celldex assets through combined technologies and intellectual property

·                  Increases Celldex’s pro forma cash to an expected $96 million at close; extends cash resources into 2012

 

NEEDHAM, MA and BRANFORD, CT (May 29, 2009):  Celldex Therapeutics, Inc. (Nasdaq: CLDX) today announced it has entered into a definitive agreement to acquire CuraGen Corporation (Nasdaq: CRGN). The acquisition will add a portfolio of oncology-focused, fully-owned antibodies to Celldex’s Precision Targeted Immunotherapy Platform. Celldex will acquire CuraGen in a tax-free stock-for-stock transaction, which values CuraGen at approximately $94.5 million, subject to certain adjustments described within the definitive agreement. In addition to its pipeline, CuraGen is expected to have a cash balance of at least $54.5 million net of certain acquisition-related costs and CuraGen convertible debt at the transaction’s close, which is anticipated to occur in the third quarter of 2009. Concurrent with the closing of the transaction, Dr. Timothy Shannon, President and Chief Executive Officer of CuraGen, will join the Celldex Board of Directors.

 

Anthony Marucci, President and Chief Executive Officer of Celldex, stated, “The CuraGen acquisition fulfills a major initiative to identify, acquire and integrate value-creating, synergistic assets to fuel our Precision Targeted Immunotherapy Platform and

 

119 FOURTH AVENUE   NEEDHAM, MA  02494-2725 USA   781-433-0771   FAX  781-433-0262

www.celldextherapeutics.com

 



 

enhance Celldex’s antibody-based technology pipeline. In addition, this acquisition further strengthens Celldex’s intellectual property estate and balance sheet, providing cash resources to advance our clinical development programs into 2012. Further, on behalf of the Celldex board and management team, I’d like to welcome Tim to our Board of Directors. We believe this transaction represents a combination that clearly exceeds the sum of its parts.”

 

Timothy Shannon, M.D., President and Chief Executive Officer of CuraGen, commented, “CuraGen’s Board of Directors considered a range of strategic alternatives to increase shareholder value and concluded that this transaction represents the best opportunity for our shareholders. We believe Celldex’s immunotherapy expertise and platform technology provide an excellent fit for our antibody portfolio, industry collaborations, technological assets and intellectual property. The deal also offers CuraGen investors reduced risk via ownership of a broader portfolio, while still retaining upside potential of CR011 in the combined company.”

 

CuraGen Corporation has a portfolio of 11 fully-owned, human antibodies that the Company selected, optimized and advanced during its collaboration with Abgenix (acquired by Amgen). CR011, currently in Phase 2 studies, is an antibody-drug conjugate that targets GPNMB, a protein that is highly expressed in metastatic breast cancer and melanoma. CR011 has shown promising early evidence of anti-tumor activity, including objective tumor responses, in patients with breast cancer and unresectable stage III and IV melanoma.

 

“Celldex’s expertise in developing novel antibody-based therapeutics will enable us to seamlessly integrate CuraGen’s antibody programs into our Precision Targeted Immunotherapy Platform and selectively identify and advance the candidates we

 

2



 

believe hold the most therapeutic promise,” said Thomas Davis, M.D., Chief Medical Officer of Celldex.

 

Celldex Therapeutics is discovering and developing innovative targeted immunotherapeutics for the treatment of cancer, infectious and inflammatory diseases. The Company’s focus is on the use of tumor-specific targets and human monoclonal antibodies to precisely deliver therapeutic agents through their novel targeted immunization approach. Celldex’s deep pipeline consists of product candidates in varying stages of development, with lead candidate CDX-110, partnered with Pfizer, currently undergoing evaluation in a Phase 2 clinical trial in newly diagnosed glioblastoma multiforme (GBM) and CDX-1307, currently enrolling in a Phase 1 study in epithelial tumors. In addition, the Company recently completed the successful preclinical development of CDX-1401, a candidate for study in multiple solid tumors.

 

The acquisition of CuraGen adds to Celldex’s clinical development program a number of important milestones anticipated over the next 12 to 18 months including:

 

·

 

Present data at ASCO in June of 2009

 

 

 

 

 

· Phase 2 CDX-110 ACT II and ACTIVATE data in GBM

 

 

 

 

 

· Phase 2 CR011 breast cancer and melanoma data

 

 

 

 

 

· Phase 1 CDX-1307 combination data in epithelial cancers

 

 

 

·

 

Continue development of and/or enrollment in core clinical programs

 

 

 

 

 

· Phase 2 ACT III study of CDX-110 in GBM; design of randomized study in GBM

 

 

 

 

 

· Phase 2 CR011 studies in breast cancer and melanoma; determine next steps for CR011 development in breast cancer and melanoma

 

 

 

 

 

· Phase 1 CDX-1307 novel combination therapy study in epithelial cancers

 

 

 

·

 

Initiate new clinical studies

 

 

 

 

 

· Phase 2 CDX-1307 randomized study in bladder cancer

 

 

 

 

 

· Phase 1/2 CDX-1401 study in multiple solid tumors

 

3



 

·

 

File at least one IND resulting from recent business development and licensing activities

 

 

 

·

 

Drive internal research to fuel an exciting pipeline of opportunities for future years

 

Transaction Terms

 

Under the terms of the definitive agreement, Celldex will acquire CuraGen in a tax-free stock-for-stock transaction, representing an equity value of approximately $94.5 million. The purchase price payable in this transaction is subject to certain adjustments described within the definitive agreement, including a collar of between 32.5% and 58% of Celldex’s outstanding common stock. The transaction, which is subject to the receipt of CuraGen and Celldex stockholder approvals and other customary closing conditions, is expected to be completed in the third quarter of 2009.

 

CuraGen is expected to deliver $68.6 million in cash, net of acquisition-related costs, including transaction fees and severance payments and a closing balance sheet adjustment. At the close of the transaction, Celldex will assume $14.1 million of CuraGen’s 4% convertible debt due in February 2011, resulting in an expected $54.5 million of net cash. The Boards of Directors of each of Celldex and CuraGen have approved the transaction and unanimously recommended that their stockholders approve the transaction.

 

Celldex was advised by WBB Securities, LLC, Brean Murray, Carret & Co., LLC and Lowenstein Sandler PC. CuraGen was advised by Piper Jaffray & Co. and Wilmer Cutler Pickering Hale and Dorr LLP.

 

Conference Call Information

 

A joint conference call will be held on Friday, May 29, 2009 at 8:30 AM ET to discuss the proposed acquisition. The conference call may be accessed by visiting 

 

4



 

www.celldextherapeutics.com or www.curagen.com. The webcast and telephonic replay will be available following the filing of the conference call transcript with the SEC.

 

Callers may also access the call with the following dial-in information:

 

Domestic phone number: (800) 299-0433

Passcode: 10533463

International phone number: (617) 801-9712

Passcode: 10533463

 

 

Callers may access the replay with the following dial-in information:

 

 

Domestic phone number: (888) 286-8010

Passcode: 97792467

International phone number: (617) 801-6888

Passcode: 97792467

 

About Celldex Therapeutics, Inc.

 

Celldex Therapeutics (Nasdaq: CLDX)  is an integrated biopharmaceutical company that applies its comprehensive Precision Targeted Immunotherapy Platform to generate a pipeline of candidates to treat cancer and other difficult-to-treat diseases. Celldex’s immunotherapy platform includes a complementary portfolio of monoclonal antibodies, antibody-targeted vaccines and immunomodulators to create novel disease-specific drug candidates. For more information, please visit www.celldextherapeutics.com.

 

About CuraGen Corporation

 

CuraGen Corporation (Nasdaq: CRGN) is a biopharmaceutical company dedicated to improving the lives of patients by developing promising pharmaceutical products that address unmet medical needs. CuraGen’s therapeutics are based on research into novel drug targets and mechanisms that are believed to play a role in the underlying disease. CuraGen has translated this research and understanding into a pipeline of protein, antibody and antibody-drug conjugate drugs. For more information, please visit www.curagen.com.

 

5



 

Additional Information about the Transaction and Where to Find It

 

This communication contains “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements are typically preceded by words such as “believes,” “expects,” “anticipates,” “intends,” “will,” “may,” “should,” or similar expressions. These forward-looking statements are subject to risks and uncertainties that may cause actual future experience and results to differ materially from those discussed in these forward-looking statements. Important factors that might cause such a difference include, but are not limited to, costs related to the transaction; failure of Celldex’s and CuraGen’s stockholders to approve the transaction; Celldex’s and CuraGen’s inability to satisfy the conditions of the transaction; the risk that Celldex’s and CuraGen’s businesses will not be integrated successfully; the combined company’s inability to further identify, develop and achieve commercial success for new products and technologies; the possibility of delays in the research and development necessary to select drug development candidates and delays in clinical trials; the risk that clinical trials may not result in marketable products; the risk that the combined company may be unable to successfully secure regulatory approval of and market its drug candidates; the risks associated with reliance on outside financing to meet capital requirements; risks of the development of competing technologies; risks related to the combined company’s ability to protect its proprietary technologies; risks related to patent-infringement claims; risks of new, changing and competitive technologies and regulations in the U.S. and internationally; and other events and factors disclosed previously and from time to time in Celldex’s and CuraGen’s filings with the SEC, including Celldex’s and CuraGen’s Annual Reports on Form 10-K for the year ended December 31, 2008. The companies do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.

 

6



 

In connection with the proposed transaction, Celldex and CuraGen intend to file relevant materials with the SEC, including a joint proxy statement/prospectus. INVESTORS ARE URGED TO READ THESE MATERIALS WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE TRANSACTION. The joint proxy statement/prospectus and other relevant materials (when they become available) and any other documents filed by Celldex or CuraGen with the SEC may be obtained free of charge at the SEC’s website at http://www.sec.gov. In addition, investors may obtain free copies of the documents filed with the SEC (i) by contacting CuraGen’s Investor Relations at (888) 436-6642 or by accessing CuraGen’s investor relations website at www.curagen.com; or (ii) by contacting Celldex’s Investor Relations at (781) 433-0771 or by accessing Celldex’s investor relations website at www.celldextherapeutics.com. Investors are urged to read the joint proxy statement/prospectus and the other relevant materials when they become available before making any voting or investment decision with respect to the transaction.

 

Participants in the Solicitation

 

The directors and executive officers of Celldex and CuraGen may be deemed to be participants in the solicitation of proxies from the holders of Celldex and CuraGen common stock in respect of the proposed transaction.  Information about the directors and executive officers of Celldex and CuraGen are set forth in Celldex’s and CuraGen’s most recent Form 10-K and Form 10-K/A, which were filed with the SEC on March 5, 2009 and April 30, 2009, respectively. Investors may obtain additional information regarding the interest of Celldex and its directors and executive officers, and CuraGen and its directors and executive officers in the proposed transaction, by reading the joint proxy statement/prospectus regarding the transaction when it becomes available.

 

7



 

This communication shall not constitute an offer to sell or the solicitation of an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction.

 

Celldex Contacts:

Avery W. Catlin

Celldex Therapeutics

Chief Financial Officer

(781) 433-0771

info@celldextherapeutics.com

 

Celldex Investor Relations:

Sarah Cavanaugh

MacDougall Biomedical Communications

(781) 235-3060

scavanaugh@macbiocom.com

 

Celldex Media:

Dan Budwick

BMC Communications Group

(973) 271-6085

dbudwick@bmccommunications.com

 

CuraGen Contacts:

Sean Cassidy

Curagen Corporation

Vice President and CFO

scassidy@curagen.com

(888) 436-6642

 

CRGN-P

 

8




Exhibit 99.2

 

GRAPHIC

Conference Call to Discuss CuraGen Acquisition May 29, 2009

 


GRAPHIC

Forward Looking Statement This communication contains "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are statements that could be forward-looking statements. You can identify these forward-looking statements through our use of words such as “may,” “will,” “can,” “anticipate,” “assume,” “should,” “indicate,” “would,” “believe,” “contemplate,” “expect,” “seek,” “estimate,” “continue,” “plan,” “point to,” “project,” “predict,” “could,” “intend,” “target,” “potential” and other similar words and expressions of the future. These forward-looking statements are subject to risks and uncertainties that may cause actual future experience and results to differ materially from those discussed in these forward-looking statements. Important factors that might cause such a difference include, but are not limited to, costs related to the transaction with CuraGen; failure of CuraGen's or Celldex's shareholders to approve Celldex's proposed acquisition of CuraGen (the "Acquisition"); CuraGen's or Celldex's inability to satisfy the conditions of the merger agreement with respect to the Acquisition; the timing, cost and uncertainty of obtaining regulatory approvals for product candidates; our ability to develop and commercialize products before competitors that are superior to the alternatives developed by such competitors; the validity of our patents and our ability to avoid intellectual property litigation, which can be costly and divert management time and attention; and the other factors listed under “Risk Factors” in our annual report on Form 10-K. Neither Celldex nor CuraGen undertakes any obligation to release publicly any revisions to such forward-looking statement to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. This communication may be deemed to be soliciting material in respect of the proposed Acquisition. In connection with the Acquisition, Celldex and CuraGen intend to file relevant materials with the SEC, including Celldex's joint registration statement/proxy statement on Form S-4. SHAREHOLDERS OF CELLDEX AND CURAGEN ARE URGED TO READ ALL RELEVANT DOCUMENTS FILED WITH THE SEC, INCLUDING CELLDEX'S JOINT REGISTRATION STATEMENT/PROXY STATEMENT, BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED ACQUISITION. Investors and shareholders will be able to obtain the documents free of charge at the SEC's web site, http://www.sec.gov, and Celldex and CuraGen shareholder will receive information at an appropriate time on how to obtain transaction-related documents for free from Celldex or CuraGen. Such documents are not currently available. Participants in the Solicitation The directors and executive officers of Celldex may be deemed to be participants in the solicitation of proxies from holders of Celldex common stock, and the directors and executive officers of CuraGen may be deemed to be participants in the solicitation of proxies from holders of CuraGen common stock, in respect of the proposed Acquisition. Information about the directors and executive officers of Celldex is set forth in Celldex's Annual Report on Form 10-K, which was filed with the SEC on March 2, 2009. Information about the directors and executive officers of CuraGen is set forth in CuraGen's Proxy Statement with respect to the election of directors, which was filed with the SEC on May 19, 2009. Investors may obtain additional information regarding the interest of Celldex and its directors and executive officers, and CuraGen and its directors and executive officers, in the proposed transaction by reading the proxy statement regarding the Acquisition when it becomes available.

 


GRAPHIC

Expands Celldex’s Precision Targeted Immunotherapy Platform with a portfolio of 11 oncology-focused antibodies, including CR011, for use as monotherapy and in novel combination approaches Increases value of both CuraGen and Celldex Increases cash to at least $96 million pro forma; extending runway into 2012 Fulfills a major initiative to identify and bring value-creating assets in-house Benefits of CuraGen Acquisition

 


GRAPHIC

Transaction Details All-stock transaction valued at $94.5 million CRGN to deliver a minimum of $68.6 million in cash CLDX to assume $14.1 million in CRGN debt Minimum yield of $54.5 million net cash; increases Company cash to at least $96 million and runway into 2012 Net of acquisition related costs, including transaction fees and severance payments 4% coupon; due in 2011 Timothy Shannon, M.D., President and CEO of CuraGen, will join the Celldex Board of Directors Anticipated close in Q3 2009

 


GRAPHIC

CuraGen: An Ideal Strategic Fit Robust portfolio of 11 oncology-focused promising human antibodies Vetted and selected from target/antibody deal with Abgenix; fully-owned Phase 2 Candidate CR011 (breast cancer and melanoma) Antibody-drug conjugate targeting GPNMB IND-track CR014 (renal and ovarian cancers) Antibody-drug conjugate targeting TIM-1 CR011 and CR014 also have potential as therapeutic antibodies Nine other novel antibody programs ready for or in preclinical studies Extensive antibody-focused IP portfolio Anticipated $54.5 million in net cash Synergistic technology, IP and resources

 


GRAPHIC

The Precision Targeted Immunotherapy Engine: Fueling New Treatments for Serious Diseases

 


GRAPHIC

Celldex Therapeutics: Leader in Immunotherapy Precision Targeted Immunotherapy Platform Primary focus is oncology and inflammatory diseases Lead candidate CDX-110 in Phase 2 study in glioblastoma multiforme Vaccine targeting the tumor-specific molecule EGFRvIII Partnered with Pfizer CDX-1307 completing Phase 1 study in epithelial tumors; will initiate Phase 2 clinical studies by year-end 2009 Antibody-vaccine to fight cancers that express hCG-β CDX-1401 entering Phase 1/2 studies in multiple solid tumors Fully-human mAb targeting cancers that express NY-ESO-1 Additional IND candidates in development

 


GRAPHIC

Significant Value Driving Events ASCO 2009 data presentations Phase 2 CDX-110 ACT II and ACTIVATE data in GBM Phase 2 CR011 breast cancer and melanoma data Phase 1 CDX-1307 combination data in epithelial cancers Ongoing enrollment/development Phase 2 ACT III study of CDX-110; design of randomized study in GBM Phase 2 CR011 studies in breast and melanoma; define next development steps by YE09 Phase 1 CDX-1307 novel combination-therapy study in epithelial cancers

 


GRAPHIC

Significant Value Driving Events Continued Initiate Phase 2 CDX-1307 randomized study in bladder cancer Initiate Phase 1/2 CDX-1401 study in multiple solid tumors Ongoing internal research to fuel a sustainable pipeline for future years File at least one IND in 2010

 


GRAPHIC

= Significant Value Creation at All Levels Combination Exceeds the Sum of its Parts Synergistic technologies and infrastructure Ability to drive exponential value instead of sequential value Programs in the clinic or promising antibody-based therapeutics Cash

 


GRAPHIC

www.celldextherapeutics.com

 



Exhibit 99.3

 

CORPORATE PARTICIPANTS

Anthony Marucci

Celldex Therapeutics, Inc. - President & CEO

Tim Shannon

CuraGen Corporation - President & CEO

Tibor Keler

Celldex Therapeutics, Inc. - SVP & CSO

Chip Catlin

Celldex Therapeutics, Inc. - SVP & CFO

Tom Davis

Celldex Therapeutics, Inc. - SVP & CMO

 

CONFERENCE CALL PARTICIPANTS

Jonathan Aschoff

Brean Murray, Carret & Co. - Analyst

Glen Gechlik

Needham & Co. - Analyst

Jason Kantor

RBC Capital Markets - Analyst

David Sugarman

CQS - Analyst

Richard Mansouri

DellaCamera Capital Management - Analyst

Thayer Koboroski

CCS Financial - Analyst

Jonathan Van Orden

Dominick & Dominick - Analyst

Jeremy Stoval

Polly Co. - Analyst

Scott Middleton

AM Investment Partners — Analyst

 

PRESENTATION

Operator

Good morning and welcome to the Celldex Therapeutics, Inc. conference call to discuss the proposed acquisition of CuraGen Corporation. My name is Erica and I will be your operator on today’s call. Before we begin our discussion, I would like to refer you to slide 2 and caution listeners that today’s speakers will be making forward-looking statements. These forward-looking statements are subject to risks and uncertainties that may cause actual future experience and results to differ materially from those discussed in the forward-looking statements.

 

This communication may be deemed to be solicitation of material in respect to the proposed acquisition by Celldex of CuraGen. The directors and executive officers of Celldex and CuraGen may be deemed as participants in the solicitation of proxies from the holders of Celldex and CuraGen common stock and respect the proposed transaction.

 

Please be advised that the question-and-answer period will be held at the close of the call. I would now like to turn the call over to Mr. Anthony Marucci, President and CEO of Celldex Therapeutics. You may proceed, sir.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Good morning and thank you for joining us. I am Anthony Marucci, President and CEO of Celldex. Joining me on the call today are Dr. Tim Shannon, President and CEO of CuraGen Corporation and the Celldex senior management team, which includes Chip Catlin, our Senior Vice President and Chief Financial Officer; Dr. Tom Davis, our Senior Vice President and Chief Medical Officer; and Dr. Tibor Keler, our Senior Vice President and Chief Scientific Officer.

 

As you know, this morning, Celldex announced that we have entered into a definitive agreement to acquire CuraGen Corporation and I want to welcome both Celldex and CuraGen shareholders to this morning’s call. We think today’s announcement is a significant milestone for both companies and we look forward to walking you through the transaction and the resulting benefits.

 

Now as you will see on slide 3, the strategic acquisition expands Celldex’s Precision Targeted Immunotherapy Platform, or PTI, with a portfolio of 11 oncology-focused antibodies that will help fuel the development of our new therapeutics in the field of cancer immunotherapy. We believe this transaction increases the value of both CuraGen and Celldex assets through a combination of technologies that should result in increased value-creating milestones and partnering opportunities. When the transaction closes, Celldex’s cash will increase to approximately $96 million, extending our reserves into 2012.

 



 

Importantly, the execution of this transaction fulfills a major Celldex initiative to identify and bring value-creating synergistic assets in-house that can then be leveraged through our integration with our PTI platform, which I will discuss in more detail later in the call.

 

[It’s] Celldex’s growth engine [and] works by combining synergistic technologies to fuel a rational design of new therapeutics and targeted regimens that maximize the beneficial aspects of the immune system. We believe CuraGen’s antibody portfolio is an ideal strategic fit for the platform and in a moment, I will turn the call over to Tim to tell you more about the CuraGen assets. But first, I would like to outline the transaction terms on slide 4. This is an all-stock transaction valued at $94.5 million dollars.

 

At the close of the deal, CuraGen will deliver a minimum of $68.6 million in cash, net of all acquisition-related costs, including transaction fees and severance payments. Celldex will assume the $14.1 million in CuraGen convertible debt, which carries a 4% coupon and is due in February of 2011. When taking both the cash and the debt into consideration, the transaction will yield a minimum of $54.5 million in net cash to Celldex at close. As I said earlier, this will increase Celldex’s cash to approximately $96 million and provide us with a runway into 2012. We will also welcome Tim Shannon of CuraGen to the Celldex Board of Directors and believe he will be a valuable addition to the Board, bringing both significant clinical and scientific experience. Lastly, we anticipate the deal to close in the third quarter of 2009. With this, I will now ask Tim to tell you more about CuraGen.

 

Tim Shannon - CuraGen Corporation - President & CEO

Thank you, Anthony. I would also like to thank our listeners for joining us today. CuraGen considered a broad range of strategic options to increase shareholder value over the last few months. And based on the synergies Anthony just outlined, we felt strongly that this transaction represented the best opportunity for our shareholders. We believe Celldex’s immunotherapy expertise and platform technology provide an excellent fit for our antibody portfolio, industry collaborations, technological assets and intellectual property.

 

Let me take a minute to walk you through CuraGen’s portfolio on slide 5. CuraGen has a robust portfolio of 11 oncology-focused, promising, fully-human antibodies. These antibodies were thoroughly studied, vetted and ultimately selected from a target antibody deal we executed with Abgenix, since bought by Amgen, to develop antibody therapeutics against the most promising antibody drug targets within the human genome.

 

The lead candidate resulting from this deal is CR011, an antibody drug conjugate that targets GPNMB, approaching overexpressed on the surface of cancer cells, including breast cancer, melanoma and glioma. CR011 utilizes antibody drug conjugation technology, which links vcMMAE, a potent chemotherapeutic, to the CR011 antibody resulting in antibody drug conjugate CR011-vcMMAE. This is the same drug conjugation technology used by Seattle Genetics in their ongoing Phase III program. CR011 has shown promising early data, including objective tumor responses in patients with advanced breast cancer and with unresectable stage III and IV melanoma. The candidate is currently in two Phase II studies, one in breast cancer and one in melanoma. We look forward to presenting updated data on CR011 at ASCO this week. The second candidate in the portfolio is CR014. CR014 is an antibody drug conjugate that targets TIM-1, a protein expressed on the surface of certain cancer cells. CR014-vcMMAE is being studied as a potential treatment for ovarian cancer and renal cell carcinoma and is prepared for IND-enabling studies. In addition, CR011 and CR014 may also have potential as therapeutic monoclonal antibodies using non-ADC mechanisms. CuraGen also brings to this transaction nine other novel antibody programs that are either currently in or ready to enter preclinical studies. We believe these programs will be highly valuable to Celldex’s Precision Targeted Immunotherapy pipeline, particularly in combination with the antibody-focused intellectual property portfolio CuraGen has built. Beyond our core clinical and technology assets, CuraGen also has a strong cash position and will deliver a minimum of $54.5 million in total net cash at the close of this transaction to support the continued development of Celldex’s broadened Precision Targeted Immunotherapy Platform, which Anthony will now discuss in more detail. Anthony?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Thank you, Tim. As I said earlier, the PTI platform is Celldex’s growth engine. It works by combining synergistic technologies to fuel the rational design of new therapeutics and targeted treatment regimens that maximize the beneficial aspects of the immune system. As you will see on slide 6, we fuel this engine with three fundamental components — immune system modulators, our antigen-presenting cell technology or APC and our therapeutic monoclonal antibody programs. I am going to take a few minutes to walk you through each of these components so you can see how the CuraGen assets fit into our overall development strategy. One of the core components includes immune system modulators or drugs that activate or suppress the immune system. For example, this includes our TLR agonists, our FLT3 program and our antibody programs targeting CD27 and CD89, which we envision as part of a combination immunotherapy regimen.

 

The next component of PTI is our APC [plat] technology, which uses human monoclonal antibodies to deliver disease-specific antigens to dendritic cells, which then direct the immune system to fight disease. The APC technology overcomes the cumbersome need for specifically manipulating each patient’s dendritic cells by directly targeting dendritic cells in vivo. This novel technology is currently in Phase I development with our lead APC candidate, CDX-1307, which also draws from our immune-modulating assets. Our therapeutic antibody programs

 



 

round out the PTI platform. These are based on a well-validated approach using antibodies to target cancer and other diseases directly or by interfering with critical interactions between the patient and the disease. With the acquisition of CuraGen, we have significantly added to the antibody component of this platform. We believe some of these antibodies have considerable therapeutic value as single agents and others have therapeutic potential that can be more fully realized as part of a combination regimen that draws from the components of the PTI platform. Celldex’s core competencies lies here in our ability to leverage these unique combined assets as appropriate for each of these three components to create novel therapeutic regimens that harness the immune system to fight disease. Turning to slide 7, I would like to tell you a little bit about Celldex and the programs the PTI platform has driven to date. While we have assets in both inflammatory and infectious diseases, our primary focus is in oncology. Our lead candidate, CDX-110, is currently in Phase II studies in glioblastoma multiforme, the most aggressive form of brain cancer. This drug was partnered with Pfizer in April of 2008 in one of the largest cancer immunotherapy deals done to date. CDX-110 is an investigational immunotherapeutic vaccine that targets the tumor-specific molecule, epidermal growth factor receptor variant III, or as it is commonly called EGFRvIII. EGFRvIII is a mutated form of the epidermal growth factor receptor that is only expressed in cancer cells and not in normal tissue and is a transforming oncogene that can directly contribute to cancer cell growth, which it does in about 40% of GBM tumors. Our second candidate in the clinic is CDX-1307, a dendritic cell targeting immunotherapy designed to focus the immune system against beta hCG, which is frequently expressed in epithelial tumors. We are currently completing a Phase I study in patients with epithelial tumors, including colorectal, pancreatic, bladder, ovarian and breast cancers. Third in the pipeline is CDX-1401, a fusion protein consisting of a fully human monoclonal antibody with specificity to the dendritic cell receptor, DEC-205 and is linked to NY-ESO-1 tumor antigen. NY-ESO-1 represents an important target for developing therapeutics against multiple cancers and CDX-1401 is intended to selectively deliver the NY-ESO-1 antigen to antigen-presenting cells that generate a robust human response against these cells that express NY-ESO-1. CDX-1401 is expected to enter Phase I/II studies in the third quarter of this year. In addition to the lead clinical programs, we have a number of additional IND candidates in active development. So as I believe you have seen in the last few slides, the combination of Celldex and CuraGen assets equates both to a robust near term product portfolio and a longer-term pipeline of opportunities in future years.

 

As we look to the next 12 to 18 months on slide 8 and 9, it is all about the execution and building and advancing a robust clinical pipeline program utilizing these combined assets. In the near term, there is a significant amount of value-driving news resulting from this transaction. First, at the American Society of Clinical Oncology annual meeting later this week, data will be presented from all four of the clinical programs we discussed here this morning, including CDX-110, Phase II, ACT II and ACTIVATE data in GBM, CR011 Phase II breast cancer and melanoma data and CDX-1301 Phase I combination data in epithelial cancers. We will continue to put a priority on the ongoing advancement of the Phase II, ACT III study in CDX-110 in GBM with Pfizer, the Phase II breast cancer and melanoma studies of CR011 and the novel combination study of CDX-1307 in epithelial cancers. We believe we’ll be in a position to make decisions on next steps for CR011 breast cancer and melanoma programs by year-end and are also working with Pfizer on the design of a randomized controlled study for CDX-110 in GBM. By year-end, we intend to initiate a Phase II study in CDX-1307 in bladder cancer and as I said previously, a Phase I/II study of CDX-1401 in multiple solid tumors.

 

We will also continue to focus on driving internal research to fuel a sustainable pipeline for the future and we will file a least one IND in 2010 resulting from our business development activities over the last year.

 

In closing, on behalf of both the Celldex and CuraGen teams, I want to thank you for joining us today. As outlined on slide 10, we believe the acquisition of CuraGen by Celldex creates a combination that exceeds the sum of its parts. As Celldex’s undertook our initiative to in-license and acquire synergistic technologies and adjuvant products, we developed a list of criteria that an ideal transaction would offer and CuraGen met all of them.

 

They bring synergistic technologies and infrastructure, which will result in an increased value for both the CuraGen and Celldex assets through a combination of technologies that should result in increased value-creating milestones and partnering opportunities. Importantly, CuraGen also brings both promising programs in the clinic and promising early-stage antibody-based therapeutics with a significant amount of cash that will help further the development plan as a whole. As a result, we believe Celldex’s acquisition of CuraGen creates significant value at all levels. With this, I would like to turn the call over to the operator and take our first question. Operator?

 

QUESTIONS AND ANSWERS

 

Operator

(Operator Instructions). Jonathan Aschoff, Brean Murray.

 

Jonathan Aschoff - Brean Murray, Carret & Co. - Analyst

Thank you. Good morning, Anthony and Tim, how are you?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

 



 

Good morning, Jonathan. We are fine; thank you.

 

Jonathan Aschoff - Brean Murray, Carret & Co. - Analyst

It’s really nice to see the cash runway for sure. And I guess I just have three questions. That was — the first would be could you discuss 011 and 014 against the closest competition, as well as which of the other nine products might get some aggressive development at CuraGen? Or are they substantially more on the back burner compared to 011 and 014? And I guess the final curiosity was what was the strike on the debt?

 

Tim Shannon - CuraGen Corporation - President & CEO

Okay, Jonathan, this is Tim Shannon and I will start with the CR011 and CR014 questions. We are very enthused about CR011.

 

That is not new and I think the combined company is very enthused about it as well. The target GPNMB really had emergent biology over the last year and a half that has increased our interest in the target — as a target in breast cancer. We alluded to earlier in the year and then have shown in the abstracts that came out, an abstract, that we are seeing clear evidence of activity in breast cancer and we will be able to update that at ASCO for both companies’ investors.

 

In terms of competition, I think the beauty about this is this is really a new target in breast cancer, which can carve out its own space based on that target expression. So again, we believe the target of GPNMB is expressed in about 25% to 40% of breast cancer patients. That compares to HER2/neu, which again is about 25%. So again, that is a very nice target and that is a definable population. So we are trying to work out the scenario where expression of GPNMB will let us select for patients who have a better chance of response to the drug, which certainly theoretically makes sense. And if we can do that, we think CR011 will fit in very nicely to the existing treatment paradigms in breast cancer where treatment choices are very much made by selection of specific agents based on receptor expression. So again, we think CR011 can be very competitive in breast cancer.

 

In melanoma, that space remains wide open. So again, GPNMB in melanoma is expressed in about 80% to 90% of metastatic melanoma patients. So again, it is a target in melanoma that should be useful in the preponderance of patients in need. Again, we think the activity we have shown thus far is very competitive with both the approved agents, as well as agents in development.

 

So again, we think CR011 can be very competitive in the melanoma space as well.

 

Jonathan Aschoff - Brean Murray, Carret & Co. - Analyst

Thank you very much for that. How about the other products beyond O11 or 014 or are they substantially on the back burner comparatively?

 

Tibor Keler - Celldex Therapeutics, Inc. - - SVP & CSO

Not at all. Jonathan, this is Tibor. So we certainly see a lot of value and opportunity within the other nine antibody programs, which have all been selected through a terrific scientific program that has really allowed the development of antibodies that target important cancers, both as potential standard therapeutic antibodies, anti-angiogenic targets, as well as drug conjugates. So from our perspective, this really provides the Celldex team as an opportunity to develop and investigate these and we will be actively looking at how to prioritize the best targets to bring them forward clinically in the near future.

 

Tim Shannon - CuraGen Corporation - President & CEO

So let me just add to that. A frustration of ours has been our inability to move those forward just because of the constraints we face. A nice synergy in this combination is the fact that Celldex has internal capabilities that can allow these to advance in a very cost-efficient fashion. Those are research capabilities, analytical capabilities, animal model capabilities and manufacturing capabilities. So again, we bring to those assets capabilities that we did not have internally any more or even at certain points in the history of CuraGen. And again, we think that is a very valuable synergy in this combination that will allow for cost-efficient potential development of those assets.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

And because we can do these activities in-house, Jonathan, it is not going to have a significant impact on burn at all.

 

Jonathan Aschoff - Brean Murray, Carret & Co. - Analyst

And how’s about the strike on the debt and you don’t owe anything on these products, correct?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Correct. They are fully paid up of milestones and royalties. And the strike on the debt I believe is $9.69.

 

Jonathan Aschoff - Brean Murray, Carret & Co. - Analyst

Okay, thank you very much.

 



 

Operator

Mark Monane, Needham & Co.

 

Glen Gechlik - Needham & Co. - Analyst

Hi, this is [Glen Gechlik] for Mark Monane. My first question is on Celldex’s combinatorial approach and I was curious if the combinatorial approach for the CuraGen assets, will they include ADCs or do you think just the naked mAbs?

 

Tibor Keler - Celldex Therapeutics, Inc. - - SVP & CSO

I think they will likely use both technologies, so certainly we are very excited about the data so far with the drug conjugates.

 

Clearly, it is an approach that is gaining a lot of credibility and effort and certainly we will be pushing along those lines. At the same time, we really see opportunities for these antibodies as standard therapeutic antibodies. Much more is known about these targets than when they were originally developed and clearly there will be opportunities to develop them through the use of their effective functions or blocking functions. So both avenues will be pursued aggressively.

 

Glen Gechlik - Needham & Co. - Analyst

I have just a couple financial questions. The first is what do you think your burn going forward will be for 2009 and 2010, just approximately?

 

Chip Catlin - Celldex Therapeutics, Inc. - - SVP & CFO

Well, I think we are going to be doing a full financial — this is Chip, I think we’ll be doing full financial projections after the close, which we expect in the third quarter. But as we said in the press release earlier, at the close of the acquisition, we expect to have cash in the range of $96 million, which really extends our cash resources into 2012.

 

Glen Gechlik - Needham & Co. - Analyst

And perhaps you can review just the financial terms of the transaction. I noted the collar between 32% and 58%. How does that work out going forward and when does the investment community get informed of the decision of the actual final deal?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Well, Glen, we will file the S-4 and the way we will work out the final price is we are going to use a 15-day random pull on the average 30-day close prior to the close of the deal. So we will take an average of the 15-days on a random basis.

 

Glen Gechlik - Needham & Co. - Analyst

And the day that the deal is finished, is that written in stone or that has to be sort of just agreed upon going forward?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Well, we are going to file the S-4 as soon as we can and we expect to close the deal sometime in the third quarter.

 

Glen Gechlik - Needham & Co. - Analyst

Thank you very much.

 

Operator

Jason Kantor, RBC Capital Markets.

 

Jason Kantor - RBC Capital Markets - Analyst

Hi, congratulations to both parties. My question is really on — it is obvious that this brings a lot of critical mass to both companies, but how does this really change the resource allocation for any of these programs? Where are the synergies in terms of cost reductions and which programs on either company are going to get increased asset allocation as a result of the transaction?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Thank you, Jason. This is Anthony Marucci. Well, the programs that are in the clinic now we believe are all doing fairly well and the data to date on 110 and CR011 and 1307 all have early good promising data. So the allocations there will not change at this point in time.

 

As far as prioritizing programs that are in preclinical development, since we do have the infrastructure in-house and the people and the expertise, we are just going to let the science drive which programs make it to the front of the line.

As far as burn goes, as I said prior, we have a lot of the expertise in-house and the infrastructure, so we don’t see a significant burn while we are able to bring forth additional products going forward.

 



 

Operator

[David Sugarman], CQS.

 

David Sugarman - CQS - Analyst

Yes, hi, guys. So some of my questions have been already asked, so just one quick bit of semantics. Can you guys give me an updated number of shares for both companies as of today?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Sure. The outstanding shares for Celldex at this point is 15.8 million.

 

Tim Shannon - CuraGen Corporation - President & CEO

And CuraGen is about 57 million.

 

David Sugarman - CQS - Analyst

Okay. And that includes all — that will — all options that will vest on closing of the deal or are there any kind of [tag-ins] around after that?

 

Tim Shannon - CuraGen Corporation - President & CEO

Well, again, it would be 57 million — about 57 million outstanding and about 3.5 million of options that would be in the money that are outstanding.

 

David Sugarman - CQS - Analyst

Okay, great. That is it. Thanks, guys.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Thank you.

 

Operator

Richard Mansouri, DellaCamera Capital Management.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

Hi, yes, thank you. Just a couple of questions. Just as far as this transaction, is there any breakup fee on either side? And also the share count with the collar, that refers to the pro forma Celldex shares outstanding? That is my first question.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Correct.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

Am I correct?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Yes.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

And in terms of — is there any like breakup fees, termination fees, anything like that?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

There will be mutual termination fees that will affect both sides equally.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

And then separately, what is your position on the potential partnering of the compound CR011? I mean I know it is just early, but it looks like there is some pretty encouraging data and I know that you guys at Celldex have been very successful and you alluded to the Pfizer transaction that you did last year. What is your thought about partnering a compound like CR011?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

If the opportunity comes about, Richard, and it makes sense for the Company to do so, we will do that. We are impressed with the data to date and we fully intend on developing the program to create even additional value. But if a company comes along and makes an attractive offer, we will certainly listen to it.

 

Tom Davis - Celldex Therapeutics, Inc. - - SVP & CMO

 



 

Maybe I can just quickly add that it has cleared the first and major hurdle in cancer drug development, which is getting clinical responses in early phase development and that, of course, is very promising. So we do think with additional data, we likely will be able to even further increase the value in CR011. So at least from my perspective, I think its value could increase significantly with some additional work. There may be a fast-track to approval if these responses are real. And with that said, it may be something that we want to keep to ourselves. So we are keeping our options open at this point. We really need to define the potential better. Just so you know, this is Tom Davis.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

So Richard, at the end of the day, we are going to do what is best for the program and the Company, whether it is keeping it or partnering it out.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

Understood. Okay, thank you.

 

Operator

[Thayer Koboroski], CCS Financial.

 

Thayer Koboroski - CCS Financial - Analyst

Hi, gentlemen. My question was regarding the terms of the deals and the closing price you are going to use, which I believe you already answered, so I don’t have any questions. Thank you.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

And in terms of — is there any like breakup fees, termination fees, anything like that?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

There will be mutual termination fees that will affect both sides equally.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

And then separately, what is your position on the potential partnering of the compound CR011? I mean I know it is just early, but it looks like there is some pretty encouraging data and I know that you guys at Celldex have been very successful and you alluded to the Pfizer transaction that you did last year. What is your thought about partnering a compound like CR011?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

If the opportunity comes about, Richard, and it makes sense for the Company to do so, we will do that. We are impressed with the data to date and we fully intend on developing the program to create even additional value. But if a company comes along and makes an attractive offer, we will certainly listen to it.

 

Tom Davis - Celldex Therapeutics, Inc. - - SVP & CMO

Maybe I can just quickly add that it has cleared the first and major hurdle in cancer drug development, which is getting clinical responses in early phase development and that, of course, is very promising. So we do think with additional data, we likely will be able to even further increase the value in CR011. So at least from my perspective, I think its value could increase significantly with some additional work. There may be a fast-track to approval if these responses are real. And with that said, it may be something that we want to keep to ourselves. So we are keeping our options open at this point. We really need to define the potential better. Just so you know, this is Tom Davis.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

So Richard, at the end of the day, we are going to do what is best for the program and the Company, whether it is keeping it or partnering it out.

 

Richard Mansouri - DellaCamera Capital Management - Analyst

Understood. Okay, thank you.

 

Operator

[Thayer Koboroski], CCS Financial.

 

Thayer Koboroski - CCS Financial - Analyst

Hi, gentlemen. My question was regarding the terms of the deals and the closing price you are going to use, which I believe you already answered, so I don’t have any questions. Thank you.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Thank you.

 



 

Operator

(Operator Instructions). Jonathan Van Orden, Dominick & Dominick.

 

Jonathan Van Orden - Dominick & Dominick - Analyst

Hi, good morning. Thanks for taking the questions. What is the exchange ratio?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Right now, as of yesterday’s close, the exchange ratio would be that the CuraGen shareholders would receive about 11.5 million shares of the Company.

 

Jonathan Van Orden - Dominick & Dominick - Analyst

11.5 million shares.  And can you kind of simply walk us through the collar and maybe provide an example of how that would work?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Sure. We have put together an upper and lower boundary on the amount of the stock that can be issued for the fixed value of the transaction. And as you know, these are customary in these transactions. So we basically are looking at the 52-week high and low for the Company just to get lower bounds and top it out what they — 32.5 on the upper bound of the spectrum if the stock price goes up to approximately $12.40. So those are basically the ranges we are looking at for Celldex’s stock.

 

Jonathan Van Orden - Dominick & Dominick - Analyst

Okay. And in terms of regulatory approvals, what is going to be required?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Well, we will file the S-4 and go through SEC approval. We don’t believe we are going to need HSR approval here, so it is just the normal SEC filings.

 

Jonathan Van Orden - Dominick & Dominick - Analyst

Okay. And have you spoken to regulators about that or is that just your assumption through your own counsel?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

It’s my assumption.

 

Jonathan Van Orden - Dominick & Dominick - Analyst

Okay. One other thing was — in the press release, you had mentioned certain closing balance sheet adjustments. What are those and are they going to affect the terms?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Well, again, we said that they will come to the table with net $54.5 million and we will have an adjustment up or down based on whether the cash is higher or lower.

 

Jonathan Van Orden - Dominick & Dominick - Analyst

Okay. Can you be more specific on that?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

We will do basically a dollar-for-dollar band on increased value.

 

Jonathan Van Orden - Dominick & Dominick - Analyst

Got you. Okay, thank you very much.

 

Operator

[Jeremy Stoval], [Polly Company].

 

Jeremy Stoval - Polly Co. - Analyst

Hi, thank you. A few quick questions. Have you received any feedback from CuraGen or Celldex shareholders about the transaction? And as far as closing conditions, is the deal subject to anything such as minimum net cash balance for CuraGen? And lastly, were there any other bids for CuraGen during this process?

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

As far as feedback from CuraGen or Celldex shareholders, not yet.  I am sure we will get some after the call. As far as the CuraGen issue —

 



 

Tim Shannon - CuraGen Corporation - President & CEO

Yes, again, I think all I can say there is, again, we had a public and very broad process again trying to identify the best option in terms of value creation for CuraGen shareholders and we think this is it.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

And to your question about minimum cash, we are looking at this as a totally synergistic deal. So we are fairly confident that all the issues can be addressed and dealt with.

 

Jeremy Stoval - Polly Co. - Analyst

Thank you.

 

Operator

Scott Middleton, AM Investment Partners.

 

Scott Middleton - AM Investment Partners - Analyst

Hi, my questions actually have all been answered. Congratulations, guys.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Thank you.

 

Operator

There are no further questions at this time.

 

Anthony Marucci - Celldex Therapeutics, Inc. - President & CEO

Thank you, operator and thank you to everyone for joining us today. I would like to encourage you to please visit either companies’ websites where you’ll find pertinent information on the transactions and transaction-related documents. In addition, we are available to answer your questions and look forward to seeing many of you at upcoming events. We will continue to report to you thoroughly throughout the year as we move our programs forward and thank you for your continued support. Have a great day.

 

Operator

Thank you for your participation in today’s conference. This concludes the presentation. Everyone, have a great day.

 



 

Additional Information about the Transaction and Where to Find It

 

This communication contains “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements are typically preceded by words such as “believes,” “expects,” “anticipates,” “intends,” “will,” “may,” “should,” or similar expressions. These forward-looking statements are subject to risks and uncertainties that may cause actual future experience and results to differ materially from those discussed in these forward-looking statements. Important factors that might cause such a difference include, but are not limited to, costs related to the transaction; failure of Celldex’s and CuraGen’s stockholders to approve the transaction; Celldex’s and CuraGen’s inability to satisfy the conditions of the transaction; the risk that Celldex’s and CuraGen’s businesses will not be integrated successfully; the combined company’s inability to further identify, develop and achieve commercial success for new products and technologies; the possibility of delays in the research and development necessary to select drug development candidates and delays in clinical trials; the risk that clinical trials may not result in marketable products; the risk that the combined company may be unable to successfully secure regulatory approval of and market its drug candidates; the risks associated with reliance on outside financing to meet capital requirements; risks of the development of competing technologies; risks related to the combined company’s ability to protect its proprietary technologies; risks related to patent-infringement claims; risks of new, changing and competitive technologies and regulations in the U.S. and internationally; and other events and factors disclosed previously and from time to time in Celldex’s and CuraGen’s filings with the SEC, including Celldex’s and CuraGen’s Annual Reports on Form 10-K for the year ended December 31, 2008. The companies do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.

 

In connection with the proposed transaction, Celldex and CuraGen intend to file relevant materials with the SEC, including a joint proxy statement/prospectus. INVESTORS ARE URGED TO READ THESE MATERIALS WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE TRANSACTION. The joint proxy statement/prospectus and other relevant materials (when they become available) and any other documents filed by Celldex or CuraGen with the SEC may be obtained free of charge at the SEC’s website at http://www.sec.gov. In addition, investors may obtain free copies of the documents filed with the SEC (i) by contacting CuraGen’s Investor Relations at (888) 436-6642 or by accessing CuraGen’s investor relations website at www.curagen.com; or (ii) by contacting Celldex’s Investor Relations at (781) 433-0771 or by accessing Celldex’s investor relations website at www.celldextherapeutics.com. Investors are urged to read the joint proxy statement/prospectus and the other relevant materials when they become available before making any voting or investment decision with respect to the transaction.

 

Participants in the Solicitation

 

The directors and executive officers of Celldex and CuraGen may be deemed to be participants in the solicitation of proxies from the holders of Celldex and CuraGen common stock in respect of the proposed transaction.  Information about the directors and executive officers of Celldex and CuraGen are set forth in Celldex’s and CuraGen’s most recent Form 10-K and Form 10-K/A, which were filed with the SEC on March 5, 2009 and April 30, 2009, respectively. Investors may obtain additional information regarding the interest of Celldex and its directors and executive officers, and CuraGen and its directors and executive officers in the proposed transaction, by reading the joint proxy statement/prospectus regarding the transaction when it becomes available.

 

This communication shall not constitute an offer to sell or the solicitation of an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction.