Nominees for Election as
Directors
J. Barrie Ward, Ph.D. Dr.
Ward has served as Chairman of the Board of Directors of AVANT since August 1998. Until January 2006, Dr. Ward was Chief Executive Officer and a
Director of KuDOS Pharmaceuticals Ltd. in Cambridge, England. Previously, he was Chairman of the Board of Directors and Chief Executive Officer of
Virus Research Institute, Inc. from July 1994 to August 1998. From 1984 to 1994, Dr. Ward was Director of the Microbiology Division of Glaxo Research
and Development Ltd. He is currently Chairman of the Board of Directors and a member of the Compensation Committee of Onyvax Ltd and on the Board of
Directors of Biotica Technology Ltd.
Una S. Ryan,
Ph.D. Dr. Ryan has been Chief Executive Officer of AVANT since August 1996 and President, Chief Operating Officer and a
director of AVANT since May 1996. Dr. Ryan joined us as Vice President, Research and Chief Scientific Officer in May 1993. She is also Research
Professor of Medicine at the Whitaker Cardiovascular Institute of the Boston University School of Medicine. Prior to joining AVANT, Dr. Ryan was
Director of Health Sciences at Monsanto Company from January 1990 to November 1992 and Research Professor of Surgery, Medicine and Cell Biology at
Washington University School of Medicine from 1990 to 1993. Dr. Ryan is a member of the Governing Body of Biotechnology Industry Organizations
(BIO) Emerging Companies Section and serves on the Board of BIO and she is the Chairman of the Massachusetts Biotechnology Council. She is currently a
director of IQuum, Inc.
Harry H. Penner,
Jr. Mr. Penner has been a director since January 1997. He is currently Chairman, Chief Executive Officer and a director of
Marinus Pharmaceuticals, Inc. He is also President and Chief Executive Officer of Nascent BioScience, LLC, a firm engaged in the creation and
development of new biotechnology companies. From 1993 to 2001, he was President, Chief Executive Officer and a director of Neurogen Corporation.
Previously, he served as Executive Vice President of Novo Nordisk A/S and President of Novo Nordisk of North America, Inc. from 1988 to 1993. From 1985
to 1988 he was Executive Vice President and General Counsel of Novo Nordisk A/S. He is Chairman of the Connecticut Board of Governors for Higher
Education and has served as Chairman of the Board for the Connecticut Technology Council and Co-Chairman of Connecticut United for Research Excellence.
He currently serves on the Boards of Altus Pharmaceuticals, Inc, Ikonisys, Inc., RHEI Pharmaceuticals, Inc. and chairs the Boards of Rib-X
Pharmaceuticals, Inc. and RxGen, Inc.
Peter A.
Sears. Mr. Sears has been a director since May 1999. Since August 2004, Mr. Sears has served as a consultant to Quaker
BioVenures, a venture capital fund. He retired in 1999 as Vice President, Business Investments, SmithKline Beecham Corporation (now GlaxoSmithKline),
and President and Founder of S.R. One, Limited, SmithKlines venture capital fund. He was with SmithKline from 1963 and S.R. One, Limited from
1985 to 1999. Since 1997 through June 2003, Mr. Sears was Adjunct Professor of Management, Johnson School of Management, Cornell University. He
currently serves on the Board of Directors of Vybion, Inc., Protez Pharmaceuticals, Inc., Smart BioSciences, Inc., Immune Control, Inc., and Fox Chase
Bank.
Karen Shoos
Lipton. Ms. Lipton has been a director since May 2001. Ms. Lipton was appointed Chief Executive Officer of the American
Association of Blood Banks in October 1994. Previously she has held senior positions at the American Red Cross since 1984, including Acting Senior Vice
President, Biomedical Services (19931994) and Secretary and General Counsel (19901993). Prior to the American Red Cross, Ms. Lipton was a
lawyer in private practice. Ms. Lipton currently serves on the Department of Health and Human Services, Advisory Committee on Blood Safety and
Availability.
Larry
Ellberger. Mr. Ellberger has been a director since August 2003. He is currently Interim Chief Executive Officer of PDI,
Inc., a diversified sales and marketing services provider to the biopharmaceutical, medical device and diagnostic industries. He was a Founder and
Principal of Healthcare Ventures Associates, Inc., a consulting firm for the pharmaceutical, biotechnology and medical device industries. From 2000 to
2003, he was Senior Vice President of Powderject plc. He served as a director of Powderject since 1997. Previously, Mr. Ellberger was an employee of
W.R. Grace & Co. from 1995 to 1999, serving as Chief
4
Financial Officer from 1996
and Senior Vice President, Strategic Planning and Development from 1995. From 1975 to 1995, Mr. Ellberger held numerous senior executive positions at
American Cyanamid Company, serving the last four years as Vice President, Corporate Development for the company.
Alf A. Lindberg, M.D.,
Ph.D. Dr. Lindberg is currently the Chief Executive Officer of Nobel Web AB, the official website of the Nobel Foundation,
and is a non-executive Director of Catella Health Care and Medivir AB in Sweden, Pharmexa A/S in Denmark and Proteome Sciences plc in the United
Kingdom. From 1993 through 2003, he was an adjunct professor in Microbiology at the Karolinska Institutet. In 1995, Dr. Lindberg was appointed
Executive Vice President of R&D at Pasteur Merieux Connaught (from 2000 Aventis Pasteur, and from 2005 Sanofi Pasteur) in Lyon, France, a position
he held until his retirement in 2001. From 1992 to 1995, Dr. Lindberg held the position of Chief Scientific Officer and Head of R&D at Wyeth
Vaccines in Pearl River, New York. From 1985 to 1993, Dr. Lindberg was a member of the Nobel Assembly and its Nobel Committee, which selects the Nobel
Laureates in Physiology and Medicine, at the Karolinska Institutet. During 1991 and 1992, he was the secretary of the Medicine Prize and a member of
the Board of Directors of the Nobel Assembly.
Francis R. Cano,
Ph.D. Dr. Cano is currently President of Cano Biotechnology Corporation. In 1996, he started the Cano Biotechnology
Corporation, where he consults with vaccine leaders, small private and public biotechnology companies, venture groups, and universities. Dr. Cano
formerly served as Chairman and Chief Executive Officer of Vaxin Inc. from 2003 to 2005 and as a director from 2001 to 2005. From 1992 to 1996, he
served as President and Chief Operating Officer of Aviron, a public biotechnology company focused on developing viral vaccines for disease prevention.
Dr. Cano began his career as a microbiologist in the vaccines division of Lederle Laboratories and during his 21-year career there he licensed seven
human vaccines. He left Lederle Laboratories as Vice President and General Manager of the vaccines division. Dr. Cano sits on the Boards of Biomerica,
Inc., Lancer Orthodontics, Inc. and Arbor Vita Corporation.
Executive
Officers
The following persons are
executive officers who are not directors of AVANT. Officers are elected annually by the Board of Directors until their successors are duly elected and
qualified.
Name of Individual
|
|
|
|
Age
|
|
Position and Office
|
M. Timothy
Cooke, Ph.D. |
|
|
|
|
47 |
|
|
Chief Operating Officer |
Avery W.
Catlin |
|
|
|
|
56 |
|
|
Senior Vice President, Chief Financial Officer and Secretary |
Ronald W.
Ellis, Ph.D. |
|
|
|
|
53 |
|
|
Senior Vice President, Research and Development |
Henry C.
Marsh, Jr., Ph.D. |
|
|
|
|
54 |
|
|
Vice President, Research |
Taha Keilani,
M.D. |
|
|
|
|
49 |
|
|
Vice President, Medical and Regulatory Affairs |
M. Timothy Cooke,
Ph.D. Dr. Cooke joined AVANT in August 2004 as Senior Vice President, Commercial Development. In March 2005, he was promoted
to Chief Operating Officer. Prior to joining the company, he was Chief Executive Officer and a Director of Mojave Therapeutics, Inc., an early stage
biopharmaceutical company developing therapeutic vaccines based on heat shock protein technology. Mojave Therapeutics was purchased by Antigenics in
July 2004. From 1991 to 2000, Dr. Cooke held a number of marketing and sales positions at the Merck Vaccine Division, most recently as Senior Director,
Worldwide Marketing Planning. He was a founding member of Merck Vaccine Divisions European and Eastern European operations, negotiated and
launched the Aventis Pasteur-MSD European vaccines joint venture and created a new vaccine-focused sales force in the United States. Dr. Cooke holds a
Ph.D. in bio-organic chemistry from Columbia University and an MBA from Columbia Business School.
Avery W.
Catlin. Mr. Catlin joined AVANT in January 2000. Prior to joining us, he served as Vice President, Operations and Finance,
and Chief Financial Officer of Endogen, Inc., a public life science research products company, from 1996 to 1999. From 1992 to 1996, Mr. Catlin held
various financial positions at
5
Repligen Corporation, a
public biopharmaceutical company, serving the last two years as Chief Financial Officer. Earlier in his career, Mr. Catlin held the position of Chief
Financial Officer at MediSense, Inc., a Massachusetts-based medical device company.
Ronald W. Ellis,
Ph.D. Dr. Ellis joined AVANT in January 2006. In 1998, Dr. Ellis joined BioChem Pharma to establish a Boston-area vaccine
development subsidiary, and continued as Senior Vice President, Development, through purchases by Shire Pharmaceuticals in 2001 and by ID Biomedical in
September 2004. In 1994, Dr. Ellis joined Astra Research Center Boston and directed their program. Previously, he spent 14 years at Merck Research
Laboratories, where he became responsible for preclinical vaccine research and was chairman of collaborations in developing pediatric combination
vaccines with partner companies.
Henry C. Marsh, Jr.,
Ph.D. Dr. Marsh joined AVANT as Senior Scientist in 1986 and has been Vice President, Research since May 1998. Prior to
joining us, he was employed as a scientist at Abbott Laboratories of North Chicago and the Research Triangle Institute in North
Carolina.
Taha Keilani,
MD, Dr. Keilani joined AVANT in June 2004 as Vice President of Medical and Regulatory Affairs. Prior to joining AVANT, Dr.
Keilani had more than eighteen years of clinical research experience in the pharmaceutical and biotechnology industries and in academic research. His
clinical development experience has been focused primarily in immunology and chronic inflammatory disease. Previously, he was Medical Director of
Clinical Development and Regulatory Affairs at Serono, Inc. where he was project leader on three global development programs. Between 1996 and 2000, he
was leading the transplant R&D team at Fujisawa Healthcare, Inc. and before that he was Research Assistant Professor of Medicine at Northwestern
University Medical School and VA Lakeside Medical Center in Chicago.
The Board of Directors and Its
Committees
Board of
Directors. AVANT is managed by a eight member Board of Directors, a majority of whom are independent of our management. Our
Board of Directors met six times in 2005. Each of the Directors attended at least 75% of the aggregate of (i) the total number of meetings of our Board
of Directors (held during the period for which such directors served on the Board of Directors) and (ii) the total number of meetings of all committees
of our Board of Directors on which the Director served (during the periods for which the director served on such committee or
committees).
Audit
Committee. The Board of Directors has established an Audit Committee consisting of Peter A. Sears, Chairman, Harry H.
Penner, Jr., and Larry Ellberger. The Audit Committee makes recommendations concerning the engagement of independent public accountants, reviews with
the independent public accountants the scope and results of the audit engagement, approves professional services provided by the independent public
accountants, reviews the independence of the independent public accountants, considers the range of audit and non-audit fees, and reviews the adequacy
of our internal accounting controls. Each member of the Audit Committee is independent as that term is defined in the rules of the
Securities and Exchange Commission and the applicable listing standards of Nasdaq. The Board has determined that each Audit Committee member has
sufficient knowledge in financial and auditing matters to serve on the Committee. The Board has designated Larry Ellberger as an audit committee
financial expert, as defined under the applicable rules of the Securities and Exchange Commission and the Nasdaq. The Audit Committee met seven
times during 2005. Our Board has adopted an Audit Committee Charter, which is available for viewing at www.avantimmune.com.nio
Compensation Committee.
The Board of Directors has established a Compensation Committee consisting of J. Barrie Ward, Chairman, Karen Shoos Lipton and Larry Ellberger. The
primary function of the Compensation Committee is to assist the Board in the establishment of compensation for the Chief Executive Officer and, upon
her recommendation, to approve the compensation of other officers and senior employees and to approve certain other personnel and employee benefit
matters. The Compensation Committee met once
6
during 2005. Our Board has
adopted a Compensation Committee Charter, which is available for viewing at www.avantimmune.com.
Nominating and Corporate
Governance Committee. The Board of Directors has established a Nominating and Corporate Governance Committee consisting of
Karen Shoos Lipton, Chairman, Harry H. Penner, Jr., and Peter A. Sears. The primary function of the Nominating and Corporate Governance Committee is to
assist the Board in reviewing, investigating and addressing issues regarding Board composition, policy and structure; membership on Board committees;
and other matters regarding the governance of the Company. The Nominating and Corporate Governance Committee met four times during 2005. Our Board has
adopted a Nominating and Corporate Governance Charter, which is available for viewing at www.avantimmune.com. Each member of the Nominating and
Corporate Governance Committee is independent as that term is defined in the rules of the Securities and Exchange Commission and the
applicable listing standards of Nasdaq.
The process followed by the
Nominating and Corporate Governance Committee to identify and evaluate candidates includes (i) the review of requests from Board members, management,
members of the Nominating and Corporate Governance Committee, stockholders and other external sources; (ii) meetings from time to time to evaluate
biographical information and background material relating to potential candidates to the Board; and (iii) interviews of selected candidates by members
of the Committee and the Board. All nominees must have, at a minimum, high personal and professional integrity, exceptional ability and judgment, and
be effective in collectively serving the long-term interests of all stockholders. Other qualifications that may be considered by the Committee are
described in the Nominating and Corporate Governance Charter.
Stockholders may recommend
individuals to the Nominating and Corporate Governance Committee for consideration as potential director candidates by submitting their names and
background to the Secretary of the Company at the address set forth below under Stockholder Communications. All such recommendations will
be forwarded to the Nominating and Corporate Governance Committee, which will review and consider only such recommendations if appropriate biographical
and other information is provided, as described below, on a timely basis. All securityholder recommendations for director candidates must be submitted
to the Company not less than 120 calendar days prior to the date on which the Companys proxy statement was released to stockholders in connection
with the previous years annual meeting, and must include the following information:
|
|
the name and address of record of the
securityholder; |
|
|
a representation that the securityholder is a record holder of
the Companys securities, or if the securityholder is not a record holder, evidence of ownership in accordance with Rule 14a-8(b)(2) of the
Securities Exchange Act of 1934; |
|
|
the name, age, business and residential address, educational
background, current principal occupation or employment, and principal occupation or employment for the preceding five (5) full fiscal years of the
proposed director candidate; |
|
|
a description of the qualifications and background of the
proposed director candidate which addresses the minimum qualifications and other criteria for Board membership approved by the Board from time to time
and set forth in the Committees written charter; |
|
|
A description of any arrangements or understandings between the
securityholder and the proposed director candidate; and |
|
|
The consent of the proposed director candidate to be named in
the proxy statement relating to the Companys annual meeting of stockholders and to serve as a director if elected at such annual
meeting. |
Assuming that appropriate
information is provided for candidates recommended by stockholders, the Committee will evaluate those candidates by following substantially the same
process, and applying
7
substantially the same
criteria, as for candidates submitted by Board members or other persons, as described above and as set forth in their written charter.
Stockholder Communications
The Board will give appropriate
attention to written communications that are submitted by stockholders, and will respond if and as appropriate. Absent unusual circumstances or as
contemplated by committee charters, and subject to advice from legal counsel, the Secretary of the Company is primarily responsible for monitoring
communications from stockholders and for providing copies or summaries of such communications to the Board as he considers
appropriate.
Communications from stockholders
will be forwarded to all directors if they relate to important substantive matters or if they include suggestions or comments that the Secretary
considers to be important for the Board to know. Communication relating to corporate governance and corporate strategy are more likely to be forwarded
to the Board than communications regarding personal grievances, ordinary business matters, and matters as to which the Company tends to receive
repetitive or duplicative communications.
Stockholders who wish to send
communications to the Board should address such communications to: The Board of Directors, AVANT Immunotherapeutics, Inc., 119 Fourth Avenue, Needham,
MA 02494, Attention: Corporate Secretary.
Section 16(a) Beneficial Ownership Reporting
Compliance
Section 16(a) of the Securities
Exchange Act of 1934, as amended, requires AVANTs directors, officers and key employees, and persons who are beneficial owners of more than 10%
of a registered class of our equity securities, to file reports of ownership and changes in ownership with the Securities and Exchange Commission (the
SEC). Officers, directors and greater than 10% beneficial owners are required by SEC regulations to furnish AVANT with copies of all
Section 16(a) forms they file. To our knowledge, based solely on a review of the copies of such reports furnished to us, and written representations
that no other reports were required during the fiscal year ended December 31, 2005, all Section 16(a) filing requirements applicable to such persons
were satisfied.
Code of Business Conduct and Ethics
We have adopted a Code of
Business Conduct and Ethics that applies to our directors, officers, and employees. The purpose of the Code of Business Conduct and Ethics is to deter
wrongdoing and to promote, among other things, honest and ethical conduct and to ensure to the extent possible that our business is conducted in a
consistently legal and ethical manner. Our Code of Business Conduct and Ethics is publicly available on our website at www.avantimmune.com. If
we make any substantive amendments to the Code of Business Conduct and Ethics or grant any waiver, including any implicit waiver from a provision of
the Code of Business Conduct and Ethics to our directors or executive officers, we will disclose the nature of such amendments or waiver on our website
or in a current report on Form 8-K.
PRINCIPAL AND MANAGEMENT STOCKHOLDERS
The following table sets forth
the amount of common stock beneficially owned as of March 1, 2006 by the following people:
|
|
each director and nominee for director; |
|
|
the Chief Executive Officer and the other most highly
compensated executive officers whose total salary and bonus exceeded $100,000 during 2005; |
8
|
|
all directors and officers as a group; and |
|
|
each person known by AVANT to hold more than 5% of our
outstanding common stock. |
Name and Business Address of Beneficial
Owners*
|
|
|
|
Amount and Nature of Beneficial
Ownership(1)
|
|
Percentage of Common Stock(2)
|
Directors
and Executive Officers
|
|
|
|
|
|
|
|
|
|
|
J. Barrie
Ward, Ph.D. |
|
|
|
|
496,415 (3 |
) |
|
|
** |
|
Una S. Ryan,
Ph.D. |
|
|
|
|
1,484,913 (4 |
) |
|
|
1.97 |
% |
Harry H.
Penner, Jr. |
|
|
|
|
105,000 (5 |
) |
|
|
** |
|
Peter A.
Sears |
|
|
|
|
152,739 (6 |
) |
|
|
** |
|
Karen Shoos
Lipton |
|
|
|
|
60,000 (7 |
) |
|
|
** |
|
Larry
Ellberger |
|
|
|
|
40,000 (8 |
) |
|
|
** |
|
Alf A.
Lindberg, M.D., Ph.D. |
|
|
|
|
|
|
|
|
|
|
Francis R.
Cano, Ph.D. |
|
|
|
|
|
|
|
|
|
|
M. Timothy
Cooke, Ph.D. |
|
|
|
|
62,000 (9 |
) |
|
|
** |
|
Avery W.
Catlin |
|
|
|
|
267,000 (10 |
) |
|
|
** |
|
Henry C.
Marsh, Jr., Ph. D. |
|
|
|
|
132,335 (11 |
) |
|
|
** |
|
Taha Keilani,
M.D. |
|
|
|
|
63,000 (12 |
) |
|
|
** |
|
|
5%
Holders
|
|
|
|
|
|
q> |
|
|
|
|
BVF
Investments, LLC |
|
|
|
|
4,515,156 (13 |
) |
|
|
6.1 |
% |
|
All
Directors and Executive Officers as a group
|
|
|
|
|
|
|
|
|
|
|
(Consisting of
12 persons) |
|
|
|
|
2,663,402 (14 |
) |
|
|
3.75 |
% |
* |
|
Unless otherwise indicated, the address is c/o AVANT
Immunotherapeutics, Inc., 119 Fourth Avenue, Needham, Massachusetts 02494-2725. |
(1) |
|
Unless otherwise indicated, the persons shown have sole voting
and investment power over the shares listed. |
(2) |
|
Common stock includes all outstanding common stock plus, as
required for the purpose of determining beneficial ownership (in accordance with Rule 13d-3(d)(1) of the Securities Exchange Act of 1934, as amended),
all common stock subject to any right of acquisition, through exercise or conversion of any security, within 60 days of the record date. |
(3) |
|
Includes 128,500 shares of common stock issuable upon exercise
of options, which are vested or will vest within 60 days of the record date. The business address of Dr. Ward is 16 St. Peters Way, Chorleywood, Herts,
WD3 5QE, England. |
(4) |
|
Includes 1,085,000 shares of common stock issuable upon exercise
of options, which are vested or will vest within 60 days of the record date. Includes 300,000 Restricted Stock Units, which are vested or will vest
within 60 days of the record date. Includes 32,000 shares owned by Dr. Ryans husband, of which Dr. Ryan disclaims beneficial
ownership. |
(5) |
|
Includes 100,000 shares of common stock issuable upon exercise
of options, which are vested or will vest within 60 days of the record date. The business address of Mr. Penner is Marinus Pharmaceuticals, Inc., 21
Business Park Drive, Branford, Connecticut 06405. |
(6) |
|
Includes 80,000 shares of common stock issuable upon exercise of
options, which are vested or will vest within 60 days of the record date. The business address of Mr. Sears is Quaker BioVentures, 1811 Chestnut
Street, Philadelphia, Pennsylvania 19103. |
(7) |
|
Includes 60,000 shares of common stock issuable upon exercise of
options, which are vested or will vest within 60 days of the record date. The business address of Ms. Lipton is American Association of Blood Banks,
8101 Glenbrook Road, Bethesda, MD 20814. |
9
(8) |
|
Includes 40,000 shares of common stock issuable upon exercise of
options, which are vested or will vest within 60 days of the record date. The business address of Mr. Ellberger is PDI, Inc., Saddle River Executive
Centre, One Route 17 South, Saddle River, NJ 07458. |
(9) |
|
Includes 62,000 shares of common stock issuable upon exercise of
options, which are vested or will vest within 60 days of the record date. |
(10) |
|
Includes 251,500 shares of common stock issuable upon exercise
of options, which are vested or will vest within 60 days of the record date. |
(11) |
|
Includes 126,500 shares of common stock issuable upon exercise
of options, which are vested or will vest within 60 days of the record date. |
(12) |
|
Includes 62,000 shares of common stock issuable upon exercise of
options, which are vested or will vest within 60 days of the record date. |
(13) |
|
On February 10, 2006, Biotechnology Value Fund, L.P.
(BVF) filed a Schedule 13G with the SEC reporting its beneficial ownership of common stock of AVANT. This Schedule 13G was filed jointly
with Biotechnology Value Fund II, L.P. (BVF2), BVF Investments, L.L.C. (Investments), Investments 10, L.L.C.
(ILL10), BVF Partners, L.P. (Partners) and BVF Inc. (BVF Inc.). Each of the these entities reported beneficial
ownership as of December 31, 2005 of 4,515,156 shares of common stock consisting of: (i) 503,037 shares of common stock beneficially owned by BVF; (ii)
349,109 shares of common stock beneficially owned by BVF2, (ii) 1,293,122 shares of common stock beneficially owned by Investments, and (iv) 112,310
shares of common stock beneficially owned by ILL10. Beneficial ownership by Partners and BVF Inc. includes 2,257,578 shares of common stock. The
principal business address of the persons comprising the group filing the Schedule 13G is 900 North Michigan Avenue, Suite 1100, Chicago, Il,
60611. |
(14) |
|
Includes 1,995,500 shares of common stock issuable upon exercise
of options and 300,000 Restricted Stock Units, which are vested or will vest within 60 days of the record date. |
COMPENSATION OF DIRECTORS AND EXECUTIVE
OFFICERS
Director Compensation
Directors who are not employees
of AVANT are each entitled to receive a retainer fee of $15,000 each fiscal year, with the Chairman of the Board receiving $20,000. Each Board
committee Chairman receives an additional retainer fee of $3,000, with the Audit Committee Chairman receiving $5,000. In addition, each non-employee
director is entitled to receive $1,500 for attendance at each meeting of the Board of Directors and $1,000 for attendance at each meeting of a Board
committee. The AVANT 1999 Stock Option and Incentive Plan provides for annual automatic grants to each independent director of an option to purchase
10,000 shares of common stock with vesting after one year, a ten year term, and an exercise price equal to the fair market value of the common stock on
the day of grant. As of the record date, the current independent directors had the following stock options outstanding: J. Barrie Ward128,500;
Harry H. Penner, Jr.100,000; Peter A. Sears80,000, Karen Shoos Lipton60,000, and Larry Ellberger40,000, Alf A.
Lindberg20,000 and Francis R. Cano20,000.
Executive Compensation
Summary Compensation
Table. The following table shows, for the fiscal years ended December 31, 2005, December 31, 2004 and December 31, 2003, the
cash compensation paid by AVANT, as well as other compensation paid or accrued for these fiscal years, to the Chief Executive Officer and the other
most highly compensated officers whose total compensation for 2005 exceeded $100,000.
10
Summary Compensation Table
|
|
|
|
|
|
|
|
|
|
Long-Term Compensation Awards
|
|
|
|
|
|
|
|
Annual Compensation
|
|
Name
and Principal Position
|
|
|
|
Year
|
|
Salary ($)
|
|
Bonus ($)
|
|
Restricted Stock Awards ($)
|
|
Securities Underlying Options (#)
|
|
All Other Compensation (2) ($)
|
Una
S. Ryan, Ph.D. |
|
|
|
|
2005 |
|
|
|
395,500 |
|
|
|
87,010 |
|
|
|
270,000 |
(1) |
|
|
|
|
|
|
2,700 |
|
President
and Chief |
|
|
|
|
2004 |
|
|
|
380,000 |
|
|
|
45,600 |
|
|
|
832,000 |
(1) |
|
|
|
|
|
|
3,940 |
|
Executive
Officer |
|
|
|
|
2003 |
|
|
|
362,000 |
|
|
|
86,880 |
|
|
|
1,104,000 |
(1) |
|
|
100,000 |
|
|
|
3,700 |
|
|
M. Timothy
Cooke, Ph.D. (3) |
|
|
|
|
2005 |
|
|
|
248,623 |
|
|
|
37,500 |
|
|
|
|
|
|
|
12,000 |
|
|
|
420 |
|
Chief
Operating Officer |
|
|
|
|
2004 |
|
|
|
96,923 |
|
|
|
6,048 |
|
|
|
|
|
|
|
200,000 |
|
|
|
180 |
|
|
|
|
|
|
2003 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Avery W.
Catlin |
|
|
|
|
2005 |
|
|
|
232,847 |
|
|
|
24,216 |
|
|
|
|
|
|
|
12,000 |
|
|
|
2,659 |
|
Senior
Vice President and |
|
|
|
|
2004 |
|
|
|
223,891 |
|
|
|
13,433 |
|
|
|
|
|
|
|
12,000 |
|
|
|
3,045 |
|
Chief
Financial Officer |
|
|
|
|
2003 |
|
|
|
215,280 |
|
|
|
25,834 |
|
|
|
|
|
|
|
10,000 |
|
|
|
2,779 |
|
|
Henry C.
Marsh, Jr., Ph.D. |
|
|
|
|
2005 |
|
|
|
187,206 |
|
|
|
19,469 |
|
|
|
|
|
|
|
10,000 |
|
|
|
2,279 |
|
Vice
President, Research |
|
|
|
|
2004 |
|
|
|
180,876 |
|
|
|
12,000 |
|
|
|
|
|
|
|
12,000 |
|
|
|
2,461 |
|
|
|
|
|
|
2003 |
|
|
|
173,919 |
|
|
|
20,870 |
|
|
|
|
|
|
|
10,000 |
|
|
|
2,346 |
|
|
Taha
Keilani, M.D. (4) |
|
|
|
|
2005 |
|
|
|
234,600 |
|
|
|
26,275 |
|
|
|
|
|
|
|
12,000 |
|
|
|
2,520 |
|
Vice
President, Medical and |
|
|
|
|
2004 |
|
|
|
128,269 |
|
|
|
6,900 |
|
|
|
|
|
|
|
50,000 |
|
|
|
934 |
|
Regulatory Affairs |
|
|
|
|
2003 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1) |
|
On September 21, 2005, AVANT awarded Dr. Ryan 200,000 Restricted
Stock Units. The Restricted Stock Units vest over four years but will vest in their entirety upon the earlier of the sale of the Company or Dr.
Ryans retirement at or after age 65. AVANT valued the Restricted Stock Units at $270,000, based on $1.35 per share, the closing price of
AVANTs common stock on the award date. On November 5, 2004, the Company awarded Dr. Ryan 400,000 Restricted Stock Units, which were valued at
$832,000 based on $2.08 per share, the closing price of AVANTs common stock on the award date, and vest over four years. On September 18, 2003,
the Company awarded Dr. Ryan 400,000 Restricted Stock Units, which were valued at $1,104,000 based on $2.76 per share, the closing price of
AVANTs common stock on the award date, and vest over four years. The value of all Restricted Stock Units as of December 31, 2005 was $1,880,000
based on $1.88 per share, the closing price of AVANTs common stock on that date. In the event that AVANT pays a stock or cash dividend on its
common stock, dividend equivalents will be paid on the Restricted Stock Units. |
(2) |
|
Includes AVANTs matching cash contribution to the 401(k)
Savings Plan of each named executive officer and premiums paid for life insurance under the Companys nondiscriminatory group plan for each named
executive officer. |
(3) |
|
Dr. Cooke joined AVANT on August 2, 2004. |
(4) |
|
Dr. Keilani joined AVANT on June 7, 2004. |
11
Options Granted in Last Fiscal Year
The following table sets forth
each grant of stock options made during the 2005 fiscal year to each of the executive officers named in the Summary compensation Table
above:
|
|
|
|
|
|
|
|
|
|
|
|
Potential Realizable Value at Assumed Annual Rates
of Price Appreciation for Option Term
|
|
|
|
|
|
Individual Grants
|
|
Name
|
|
|
|
Number of Securities Underlying Options
Granted (#)
|
|
Percent of Total Options Granted to
Employees in Fiscal Year (1)
|
|
Exercise Per Share Price ($/Sh) (2)
|
|
Expiration Date
|
|
5% ($)
|
|
10% ($)
|
Una S. Ryan,
Ph.D. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
M. Timothy Cooke,
Ph.D. |
|
|
|
|
12,000 |
|
|
|
5 |
% |
|
|
2.0750 |
|
|
|
01/03/15 |
|
|
|
15,659 |
|
|
|
39,684 |
|
Avery W.
Catlin |
|
|
|
|
12,000 |
|
|
|
5 |
% |
|
|
2.0750 |
|
|
|
01/03/15 |
|
|
|
15,659 |
|
|
|
39,684 |
|
Henry C. Marsh,
Jr., Ph.D. |
|
|
|
|
10,000 |
|
|
|
4 |
% |
|
|
2.0750 |
|
|
|
01/03/15 |
|
|
|
13,050 |
|
|
|
33,070 |
|
Taha Keilani,
M.D. |
|
|
|
|
12,000 |
|
|
|
5 |
% |
|
|
2.0750 |
|
|
|
01/03/15 |
|
|
|
15,659 |
|
|
|
39,684 |
|
(1) |
|
During the 2005 fiscal year, a total of 46,000 stock options
were granted to the executive officers named in the Summary Compensation Table above. These options vest over four years and have a ten-year term.
During 2005, a total of 222,300 stock options were granted to employees of AVANT. |
(2) |
|
Equal to the average of the high and low market prices of the
common stock on the grant date. |
Aggregated Option Exercises in Last Fiscal Year and Fiscal
Year End Option Values
The following table sets forth,
for each of the executive officers named in the Summary Compensation Table above, the shares of common stock acquired and the value realized in each
exercise of stock options during the 2005 fiscal year and the fiscal year end number and value of unexercised options:
|
|
|
|
|
|
|
|
Number of Securities Underlying Unexercised
Options at Fiscal Year End (#)
|
|
Value of Unexercised In-the-Money Options at
Fiscal Year End (1) ($)
|
|
Name
|
|
|
|
Shares Acquired on Exercise (#)
|
|
Value Realized ($)
|
|
Exercisable
|
|
Unexercisable
|
|
Exercisable
|
|
Unexercisable
|
Una S. Ryan,
Ph.D. |
|
|
|
|
|
|
|
|
|
|
|
|
1,060,000 |
|
|
|
50,000 |
|
|
|
208,950 |
|
|
|
37,000 |
|
M. Timothy Cooke,
Ph.D. |
|
|
|
|
|
|
|
|
|
|
|
|
62,000 |
|
|
|
150,000 |
|
|
|
|
|
|
|
3,700 |
|
Avery W.
Catlin |
|
|
|
|
5,000 |
|
|
|
3,150 |
|
|
|
249,000 |
|
|
|
5,000 |
|
|
|
|
|
|
|
|
|
Henry C. Marsh,
Jr., Ph.D. |
|
|
|
|
|
|
|
|
|
|
|
|
129,000 |
|
|
|
5,000 |
|
|
|
7,691 |
|
|
|
3,700 |
|
Taha Keilani,
M.D. |
|
|
|
|
|
|
|
|
|
|
|
|
62,000 |
|
|
|
|
|
|
|
|
|
|
|
|
|
(1) |
|
Based on the $1.88 per share closing price of AVANTs
common stock on December 31, 2005. |
Employment Contracts, Termination of Employment and
Change-of-Control Arrangements
Dr. Ryan entered into an
agreement with AVANT on August 20, 1998 which was amended and restated as of December 23, 2002 and again as of September 18, 2003. The term of the
agreement is for one (1) year with rolling automatic one-year extensions. If prior to a change in control (as defined in the AVANT Immunotherapeutics,
Inc. 1999 Stock Option and Incentive Plan), Dr. Ryans employment is terminated by the Company without cause (as defined in the agreement), Dr.
Ryan will be eligible to receive a lump sum amount equal to one years salary, at the rate then in effect, and continuation of group health plan
benefits for a period of up to twelve (12) months. If within a year after a change in control, Dr. Ryans employment is terminated by the Company
without cause or by Dr. Ryan for good reason (as defined in the agreement), or if a change in control occurs within one (1) year after Dr. Ryan is
terminated without cause by the Company, Dr. Ryan is entitled to receive a lump sum amount equal to three (3) times the base amount (as defined in
Section 280G(b)(3) of the Internal Revenue Code of 1986, as
12
amended) applicable to Dr.
Ryan, less one dollar ($1.00). Such severance may be further reduced to the extent necessary to preserve the Companys tax
deduction.
Dr. Cooke entered into a letter
agreement with AVANT on June 10, 2004 (the Letter Agreement), which provides for the Companys employment of Dr. Cooke, as a Senior
Vice President of Commercial Development, on an at-will basis, beginning on June 21, 2004. Under the terms of the Letter Agreement, if (1) there has
been a Change of Control of the Company (as defined in the Letter Agreement) and Dr. Cookes employment is thereafter terminated by Dr. Cooke for
other than Good Reason (as defined in the Letter Agreement), or (2) there has been a Change of Control of the Company and Dr. Cookes employment
is thereafter terminated for Cause (as defined in the Letter Agreement) by the Company, death, Disability or Retirement (each as defined in the Letter
Agreement), then no benefits shall be payable to Dr. Cooke. If Dr. Cookes employment is terminated within one (1) year following a Change in
Control of the Company by Dr. Cooke for Good Reason or by the Company other than for Cause, death, Disability or Retirement, then Dr. Cookes
benefits shall be those described in the Letter Agreement, including the continuance of Dr. Cookes base salary for 12 months and a 100% vesting
of all unvested options. On June 14, 2004 Dr. Cookes employment terms were amended (the Amended Letter Agreement) such that the
Company agreed to pay Dr. Cooke six months of severance (at the rate of his final base pay) if Dr. Cookes employment is terminated by the
Company without cause. This Amended Letter Agreement also allows for Dr. Cooke to receive health and dental benefits during this severance period. Dr.
Cooke has since been promoted to Chief Operating Officer, however, his employment terms pursuant to this Letter Agreement remain the
same.
Mr. Catlin has an agreement with
AVANT under which he is eligible for a severance payment of twelve months base salary, continuation of health insurance benefits and 100% vesting
of all stock option grants in the event of his termination following a change-of-control, as defined in the AVANT Immunotherapeutics, Inc. 1999 Stock
Option and Incentive Plan.
13
REPORT OF THE COMPENSATION COMMITTEE
The Compensation Committee of the
Board of Directors, which is comprised of non-employee directors, is responsible for establishing and administering the policies governing the
compensation of AVANTs employees, including salary, bonus and stock option grants. The policy of the Compensation Committee is to compensate our
employees with competitive salaries based on their level of experience and job performance. All permanent employees, including executive officers, are
eligible for annual bonus awards based on achievement of AVANTs strategic corporate goals, and participation in our stock option program. The
bonus awards and stock option grants are made in accordance with the AVANT Performance Plan and 1999 Stock Option and Incentive Plan. The Compensation
Committee is also responsible for the administration of our 1994 Employee Stock Purchase Plan, in which employees participate on a voluntary
basis.
In order to both attract and
retain experienced and qualified executives to manage AVANT, the Compensation Committees policy on executive compensation is to (i) pay salaries
which are competitive with the salaries of executives in comparable positions in the biotechnology industry, and (ii) allow for additional compensation
upon achievement of goals under the Performance Plan and through the appreciation of stock-based incentive awards. This policy is designed to have a
significant portion of each executives total compensation be tied to AVANTs progress in order to incentivize the executive to fully
dedicate himself or herself to achievement of corporate goals, and to align the executives interest with those of our stockholders through equity
incentive compensation.
Each executive officer (except
the Chief Executive Officer whose performance is reviewed by the Compensation Committee) has an annual performance review with the Chief Executive
Officer who makes recommendations on salary increases, promotions and stock option grants to the Compensation Committee. The recommended salary
increases are based on the average salary increases expected in the biotechnology industry in the Boston, Massachusetts area, with the salaries in 2005
either at or slightly above the average of the salaries paid to persons in comparable positions using an independently prepared 2005 employee
compensation survey of over 400 biotechnology companies.
The bonus award is based on
achievement of AVANTs strategic goals which are set at the beginning of each fiscal year and measured against performance at the end of the year
by AVANT in accordance with the Performance Plan. For 2005 two sets of goals were applicable to all employees, including the executive officers: (i)
overall corporate goals and (ii) goals applicable to the therapeutic programs. Both sets of goals were allocated between specific product and financial
performance targets.
Dr. Una Ryan, our President and
Chief Executive Officer, received a salary increase of 4% in 2005. Dr. Ryans current base salary, which reflects the salary increase, is within
the range of base salaries paid to other Chief Executive Officers in similar sized, publicly traded companies in the biotechnology industry, based on
the previously referenced 2005 employee compensation survey. As discussed above, the Compensation Committee determined that Dr. Ryan had met certain
milestones in 2005 and that a cash payout of $87,010 would be made to Dr. Ryan under the Performance Plan for 2005.
On January 6, 2006, Drs. Cooke,
Marsh and Keilani and Mr. Catlin were granted options to purchase 100,000 shares, 12,000 shares, 50,000 shares and 25,000 shares, respectively, of
AVANT common stock at an exercise price of $2.04. These options vest over four years and have a ten-year term.
Compensation
Committee
J. Barrie Ward,
Chairman
Karen Shoos Lipton
Larry Ellberger
14
Compensation Committee Interlocks and Insider
Participation
The Compensation Committee of the
Board of Directors was composed of three non-employee directors during the year, Messrs. J. Barrie Ward, Karen Shoos Lipton and Larry Ellberger. None
of these Compensation Committee members is an officer or employee of AVANT. Dr. Ward was formerly an employee of AVANT and was a consultant for the
Company until December 31, 2004. Dr. Ward did not participate in actions or discussions with respect to his own compensation. No Compensation Committee
interlocks between AVANT and another entity exist.
REPORT OF THE AUDIT COMMITTEE
The undersigned members of the
Audit Committee of the Board of Directors of AVANT submit this report in connection with the committees review of the financial reports for the
fiscal year ended December 31, 2005 as follows:
1. |
|
The Audit Committee has reviewed and discussed with management
the audited financial statements for AVANT for the fiscal year ended December 31, 2005. |
2. |
|
The Audit Committee has discussed with representatives of
PricewaterhouseCoopers LLP the matters which are required to be discussed with them under the provisions of SAS 61. That Statement of Accounting
Standards requires the auditors to ensure that the Audit Committee received information regarding the scope and results of the audit.
PricewaterhouseCoopers LLP has also communicated with the Audit Committee on matters required by Rule 2-07 of Regulation S-X. |
3. |
|
The Audit Committee has discussed with PricewaterhouseCoopers
LLP, the independent public accounting firm, the auditors independence from management and AVANT including the matters in the written disclosures
and the letter from the independent auditors required by the Independence Standards Board, Standard No. 1. |
In addition, the Audit Committee
considered whether the provision of information technology services or other non-audit services by PricewaterhouseCoopers LLP is compatible with
maintaining its independence. In reliance on the reviews and discussions referred to above, the Audit Committee recommended to the Board of Directors
(and the Board has approved) that the audited financial statements be included in AVANTs Annual Report on Form 10-K for the fiscal year ended
December 31, 2005 for filing with the Securities and Exchange Commission.
Audit
Committee
Peter A. Sears,
Chairman
Harry H. Penner, Jr.
Larry Ellberger
15
INDEPENDENT REGISTERED PUBLIC ACCOUNTING
FIRM
The Audit Committee has approved
the engagement of PricewaterhouseCoopers, LLP as the Companys independent registered public accounting firm. We expect that a representative from
PricewaterhouseCoopers, LLP will be present at the annual meeting to make a statement if he or she desires to do so and to respond to appropriate
questions.
Audit Fees
Represents fees for professional
services provided in connection with the audit of the Companys annual audited financial statements and reviews of the Companys quarterly
financial statements, advice on accounting matters directly related to the audit and audit services provided in connection with other statutory or
regulatory filings. Fees, including out of pocket expenses, for the fiscal year 2005 audit, including assurance services provided in connection with
the assessment and testing of internal controls pursuant to Section 404 of the Sarbanes-Oxley Act of 2002, and the quarterly reviews of Forms 10-Q
during fiscal 2005 were $315,075, of which an aggregate amount of $126,275 had been billed through December 31, 2005. Audit fees for fiscal 2004,
including out of pocket expenses, were $248,320.
Audit-Related Fees
Audit-related fees are for
assurance and other activities not explicitly related to the audit of the Companys financial statements, and consisted principally of fees for
consultations concerning financial accounting and reporting standards. No audit-related fees, including out of pocket expenses, were billed by
PricewaterhouseCoopers, LLP in fiscal year 2005. Audit-related fees for fiscal 2004, including out of pocket expenses, were $38,000.
Tax Fees
Tax fees are associated with tax
compliance, tax advice, tax planning and tax preparation services. In 2005 and 2004, we engaged another public accounting firm to perform these
services.
All Other Fees
Other fees of $1,500 were billed
by PricewaterhouseCoopers, LLP in fiscal years 2005 and 2004.
The Audit Committee is
responsible for appointing, setting compensation and overseeing the work of the independent auditors. The Audit Committee has established a policy
regarding pre-approval of all auditing services and the terms thereof and non-audit services (other than non-audit services prohibited under Section
10A(g) of the Exchange Act or the applicable rules of the SEC or the Public Company Accounting Oversight Board) to be provided to the Company by the
independent auditor. However, the pre-approval requirement may be waived with respect to the provision of non-audit services for the Company if the
de minimus provisions of Section 10A(i)(1)(B) of the Exchange Act are satisfied.
The Audit Committee has
considered whether the provision of Audit-Related Fees, Tax Fees, and all other fees as described above is compatible with maintaining
PricewaterhouseCoopers, LLPs independence and has determined that such services for fiscal years 2005, 2004 and 2003 were compatible. All such
services were approved by the Audit Committee pursuant to Rule 2-01 of Regulation S-X under the Exchange Act to the extent that rule was
applicable.
16
STOCK PERFORMANCE GRAPH
The graph below represents a
comparison of the cumulative shareholder return on the common stock for AVANTs last five fiscal years, including the fiscal year ended December
31, 2005, with the cumulative total stockholder return of the Nasdaq Stock Market (U.S.) Index and Nasdaq Pharmaceutical Stock Index (which is made up
of companies quoted on the Nasdaq National Market whose Primary Industrial Classification Code is 283, Pharmaceutical Companies). The graph assumes an
investment of $100 made on December 31, 2000 in AVANTs common stock and in the two indexes.
|
|
|
|
12/29/00
|
|
12/31/01
|
|
12/31/02
|
|
12/31/03
|
|
12/31/04
|
|
12/30/05
|
AVANT
Immunotherapeutics, Inc. |
|
|
|
$ |
100 |
|
|
$ |
58 |
|
|
$ |
17 |
|
|
$ |
40 |
|
|
$ |
29 |
|
|
$ |
27 |
|
Nasdaq Stock
Market (U.S.) Index |
|
|
|
$ |
100 |
|
|
$ |
79 |
|
|
$ |
55 |
|
|
$ |
82 |
|
|
$ |
89 |
|
|
$ |
91 |
|
Nasdaq
Pharmaceutical Stock Index |
|
|
|
$ |
100 |
|
|
$ |
85 |
|
|
$ |
55 |
|
|
$ |
81 |
|
|
$ |
86 |
|
|
$ |
95 |
|
17
OTHER MATTERS
Expenses of Solicitation
The expense of preparing,
printing and mailing the notice of annual meeting of stockholders and proxy material, and all other expenses of soliciting proxies will be borne by
AVANT. We have retained ADP Financial Services, Inc. as agent for soliciting proxies. Officers or other employees of AVANT may, without additional
compensation therefore, solicit proxies in person, by telephone, facsimile, mail or the Internet. We may also reimburse brokerage firms, banks,
trustees, nominees and other persons for their expenses in forwarding proxy material to the beneficial owners of shares held by them of
record.
Stockholder Proposals for 2007 Annual
Meeting
Any stockholder proposals
submitted pursuant to Exchange Act Rule 14a-8 for inclusion in AVANTs proxy statement and form of proxy for our 2007 annual meeting must be
received by AVANT on or before December 20, 2006 in order to be considered for inclusion in our proxy statement and form of proxy. Such proposal must
also comply with the requirements as to form and substance established by the SEC if such proposals are to be included in the proxy statement and form
of proxy. Any such proposal shall be mailed to: AVANT Immunotherapeutics. Inc., 119 Fourth Avenue, Needham, MA 02494-2725, Attn.:
Secretary.
Shareholder proposals to be
presented at AVANTs 2007 annual meeting, other than stockholder proposals submitted pursuant to Exchange Act Rule 14a-8, must be received in
writing at the principal executive office of AVANT Immunotherapeutics, Inc., 119 Fourth Avenue, Needham, MA 02494-2725 not earlier than January 8, 2007
nor later than March 4, 2007 unless our 2007 annual meeting of stockholders is scheduled to take place before April 8, 2007 or after July 7, 2007. Our
by-laws state that the stockholder must provide timely written notice of such nomination or proposal and supporting documentation as well as be present
at such meeting, either in person or by a representative. A stockholders notice shall be timely received by AVANT at our principal executive
office not less than seventy-five (75) days nor more than one hundred twenty (120) days prior to the anniversary date of the immediately preceding
annual meeting (the Anniversary Date); provided, however, that in the event the annual meeting is scheduled to be held on a date more than
thirty (30) days before the Anniversary Date or more than sixty (60) days after the Anniversary Date, a stockholders notice shall be timely if
received by AVANT at our principal executive office not later than the close of business on the later of (1) the seventy-fifth (75th) day prior to the scheduled date of such annual meeting or (2) the fifteenth (15th) day following the day on which such public announcement of the date of such annual meeting
is first made by AVANT. Proxies solicited by our Board of Directors will confer discretionary voting authority with respect to these proposals, subject
to SEC rules and regulations governing the exercise of this authority. Any such proposal shall be mailed to: AVANT Immunotherapeutics. Inc., 119 Fourth
Avenue, Needham, MA 02494-2725, Attn.: Corporate Secretary.
18
AVANT IMMUNOTHERAPEUTICS, INC.
119 FOURTH AVENUE
NEEDHAM, MASSACHUSETTS 02494 |
VOTE BY
INTERNET - www.proxyvote.com
Use the Internet to transmit your voting instructions and for electronic
delivery of information up until 11:59 P.M. Eastern Time the day before
the cut-off date or meeting date. Have your proxy card in hand when
you access the web site and follow the instructions to obtain your records
and to create an electronic voting instruction form.
ELECTRONIC DELIVERY OF FUTURE SHAREHOLDER
COMMUNICATIONS
If you would like to reduce the costs incurred by AVANT Immunotherapeutics,
Inc. in mailing proxy materials, you can consent to receiving all future
proxy statements, proxy cards and annual reports electronically via
e-mail or the Internet. To sign up for electronic delivery, please follow
the instructions above to vote using the Internet and, when prompted,
indicate that you agree to receive or access shareholder communications
electronically in future years.
VOTE BY PHONE - 1-800-690-6903
Use any touch-tone telephone to transmit your voting instructions up
until 11:59 P.M. Eastern Time the day before the cut-off date or meeting
date. Have your proxy card in hand when you call and then follow the
instructions.
VOTE
BY MAIL
Mark, sign and date your proxy card and return it in the postage-paid
envelope we have provided or return it to AVANT Immunotherapeutics,
Inc., c/o ADP, 51 Mercedes Way, Edgewood, NY 11717.
|
TO
VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS: |
AVANT1 |
KEEP
THIS PORTION FOR YOUR RECORDS |
|
|
DETACH
AND RETURN THIS PORTION ONLY |
THIS
PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. |
AVANT
IMMUNOTHERAPEUTICS, INC. |
|
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|
|
|
|
|
|
|
1. |
Election
of Directors. |
|
|
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|
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|
Nominees: |
|
|
|
|
|
|
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|
|
|
(01) J. Barrie
Ward
(02) Una S. Ryan
(03) Harry H. Penner, Jr.
(04) Peter A. Sears
(05) Karen Shoos Lipton
(06) Larry Ellberger
(07) Alf A. Lindberg
(08) Francis R. Cano |
|
For
All
o
|
|
Withhold
All
o |
|
For
All
Except
o |
|
To
withhold authority to vote, mark "For All Except"
and write the nominee's number on the line below.
|
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|
Please
sign exactly as your name(s) appear(s) on the books of the Company. Joint
owners should each sign personally. Trustees and other fiduciaries should
indicate the capacity in which they sign, and where more than one name
appears, a majority must sign. If a corporation, this signature should
be that of an authorized officer who should state his or her title. |
|
|
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|
Please
be sure to sign and date this Proxy. |
|
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HOUSEHOLDING
ELECTION - Please indicate if you consent to receive certain
future investor communications in a single package per household. |
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Signature [PLEASE
SIGN WITHIN BOX] |
Date |
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Signature (Joint
Owners) |
Date |
AVANT IMMUNOTHERAPEUTICS, INC.
Proxy Solicited by the Board of Directors for the
Annual Meeting of Stockholders
on May 18, 2006
The
undersigned hereby appoints J. Barrie Ward and Una S. Ryan, and each of them,
as the true and lawful attorneys, agents and proxies of the undersigned, with
full power of substitution, and hereby authorizes them to represent and to vote,
as designated on the reverse, all shares of Common Stock held of record by the
undersigned on April 5, 2006, at the Annual Meeting of Stockholders (the Meeting)
to be held at 2:00 p.m. on May 18, 2006 at the Companys Fall River manufacturing
facility located at 151 Martine Street, Fall River, Massachusetts 02723, or
at any adjournment or postponement thereof.
When properly executed, this proxy will be voted in the manner directed herein
by the undersigned stockholder(s). If no direction is given in connection with
Proposal 1, this proxy will be voted FOR the election of the nominees for director
and, in their discretion, the proxies are each authorized to vote upon such
other business as may properly come before the Meeting and any adjournments
or postponements thereof. Any stockholders wishing to vote in accordance with
the Board of Directors recommendations need only sign and date this proxy
and return it in the postage-paid envelope provided.
The undersigned hereby acknowledges(s) receipt of a copy of the accompanying
Notice of Annual Meeting of Stockholders, the Proxy Statement with respect thereto
and the Companys 2005 Annual Report to Stockholders, and hereby revoke(s)
any proxy or proxies heretofore given. This proxy may be revoked at any time
before it is executed.
PLEASE
VOTE, DATE, AND SIGN ON REVERSE SIDE
AND RETURN PROMPTLY IN THE ENCLOSED ENVELOPE.