SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Nicholson Mary (Last) (First) (Middle) 268 CONCORD ROAD (Street) WESTON MA 02493 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 06/04/2004	3. Issuer Name and Ticker or Trading Symbol AVANT IMMUNOTHERAPEUTICS INC [ AVAN ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner Officer (give title below) X Other (specify below) Sr. Dir Ops Mfg	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Incentive Stock Opton	12/10/2004	12/10/2013	Common Stock	10,000	2.51	D

Explanation of Responses:

	Mary Nicholson	06/04/2004
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

LIMITED POWER OF ATTORNEY
FOR
AVANT IMMUNOTHERAPEUTICS, INC.
SECTION 16(a) FILINGS


Know all men by these presents, that the
undersigned hereby constitutes and appoints each of
Avery W. Catlin and Una S. Ryan, signing singly, the
undersigned's true and lawful attorney-in-fact to:

(1)	execute for and on behalf of the
undersigned, in the undersigned's capacity
as an officer, director and/or stockholder
of AVANT Immunotherapeutics, Inc. (the
"Company"), Forms 3, 4, and 5 and any
amendments thereto in accordance with
Section 16(a) of the Securities Exchange Act
of 1934 and the rules thereunder;

(2)	do and perform any and all acts for and on
behalf of the undersigned which may be
necessary or desirable to complete and
execute any such Form 3, 4, or 5 or
amendment thereto and timely file such form
with the United States Securities and
Exchange Commission (the "SEC") and any
stock exchange or similar authority; and

(3)	take any other action of any type whatsoever
which, in the opinion of such attorney-in-
fact, may be necessary or desirable in
connection with the foregoing authority, it
being understood that the documents executed
by such attorney-in-fact on behalf of the
undersigned pursuant to this Power of
Attorney shall be in such form and shall
contain such terms and conditions as such
attorney-in-fact may approve.

The undersigned hereby grants to each such
attorney-in-fact full power and authority to do and
perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the
exercise of any of the rights and powers herein
granted, as fully to all intents and purposes as the
undersigned might or could do if personally present,
with full power of substitution or revocation, hereby
ratifying and confirming all that such attorney-in-
fact, or such attorney-in-fact's substitute or
substitutes, shall lawfully do or cause to be done by
virtue of this Power of Attorney and the rights and
powers herein granted.  The undersigned acknowledges
that the foregoing attorneys-in-fact, in serving in
such capacity at the request of the undersigned, are
not assuming, nor is the Company assuming, any of the
undersigned's responsibilities to comply with
Section 16 of the Securities Exchange Act of 1934.

This Power of Attorney shall remain in full force
and effect until the undersigned is no longer required
to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in
securities of the Company, unless earlier revoked by
the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.  This Power of Attorney
may be filed with the SEC as a confirming statement of
the authority granted herein.



IN WITNESS WHEREOF, the undersigned has caused
this Limited Power of Attorney to be executed as of
this 27th day of May, 2004.







						/s/ Mary Nicholson

	Signature



	Mary Nicholson
						Print Name



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