UNITED STATES
                                   SECURITIES
                             & EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                              (Amendment No. __)*


                         AVANT Immunotherapeutics, Inc.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)


                                   053491106


                                 (CUSIP Number)


                                  July 1, 2003
             (Date of event which requires filing of this statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule 13G is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)




- ----------------
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934 ("Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).









                                Page 1 of 6 Pages


CUSIP No. 053491106 13G Page 2 of 6 Pages - ----------------------------------------------------------------------- (1) NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS Millennium Partners, L.P. - ----------------------------------------------------------------------- (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** (a) [ ] (b) [X] - ----------------------------------------------------------------------- (3) SEC USE ONLY - ----------------------------------------------------------------------- (4) CITIZENSHIP OR PLACE OF ORGANIZATION Cayman Islands - ----------------------------------------------------------------------- NUMBER OF (5) SOLE VOTING POWER 4,888,888 SHARES -------------------------------------------------- BENEFICIALLY (6) SHARED VOTING POWER 0 OWNED BY -------------------------------------------------- EACH (7) SOLE DISPOSITIVE POWER 4,888,888 REPORTING -------------------------------------------------- PERSON WITH (8) SHARED DISPOSITIVE POWER 0 - ----------------------------------------------------------------------- (9) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,888,888 - ----------------------------------------------------------------------- (10) CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ** [ ] - ----------------------------------------------------------------------- (11) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 7.48% - ----------------------------------------------------------------------- (12) TYPE OF REPORTING PERSON ** PN - ----------------------------------------------------------------------- ** SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 053491106 13G Page 3 of 6 Pages Item 1. (a) Name of Issuer AVANT Immunotherapeutics, Inc., a Delaware corporation (the "Company"). (b) Address of Issuer's Principal Executive Offices: 119 Fourth Avenue Needham, Massachusetts 02494-2725 Item 2(a). Name of Person Filing: Millennium Partners, L.P. Item 2(b). Address of Principal Business Office: c/o Millennium Management, L.L.C. 666 Fifth Avenue New York, New York 10103 Item 2(c). Citizenship: Cayman Islands Item 2(d) Title of Class of Securities: Common Stock, par value $0.001 per share ("Common Stock") Item 2(e) CUSIP Number: 053491106 Item 3. If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: (a) [ ] Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o). (b) [ ] Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c). (c) [ ] Insurance company as defined in Section 3(a)(19) of the Act (15 U.S.C. 78c). (d) [ ] Investment company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). (e) [ ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E); (f) [ ] An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F); (g) [ ] A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G); (h) [ ] A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

CUSIP No. 053491106 13G Page 4 of 6 Pages (i) [ ] A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3); (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J). If this statement is filed pursuant to Rule 13d-1(c), check this box. [X] Item 4. Ownership. Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1. (a) Amount beneficially owned: As of the date of this filing, the Reporting Person may be deemed the beneficial owner of (i) 4,444,444 shares of Common Stock held outright by Riverview Group, LLC, a Delaware limited liability company and wholly-owned subsidiary of the Reporting Person ("Riverview") and (ii) 444,444 shares of Common Stock currently issuable to Riverview upon the exercise of certain warrants. (b) Percent of class: Approximately 7.48% as of the date of this filing. (Based on the Company's Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2003, there were 60,468,690 shares of Common Stock issued and outstanding as of May 8, 2003. In addition, on July 1, 2003, the Company issued Riverview the 4,444,444 shares of Common Stock and the warrants to purchase 444,444 shares of Common Stock referred to in the first paragraph of Item 4(a) above.) (c) Number of shares as to which such person has: (i) Sole power to vote or to direct the vote: 4,888,888 shares of Common Stock. (ii) Shared power to vote or to direct the vote 0 (iii) Sole power to dispose or to direct the disposition of 4,888,888 shares of Common Stock. (iv) Shared power to dispose or to direct the disposition of 0 Item 5. Ownership of Five Percent or Less of a Class Not applicable.

CUSIP No. 053491106 13G Page 5 of 6 Pages Item 6. Ownership of More than Five Percent on Behalf of Another Person. Not applicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person. The 4,444,444 shares of Common Stock and the warrants to purchase 444,444 shares of Common Stock referred to in the first paragraph of Item 4(a) above are held by Riverview. Item 8. Identification and Classification of Members of the Group This statement is filed by: Not applicable. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification By signing below the undersigned certifies that, to the best of its knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

CUSIP No. 053491106 13G Page 6 of 6 Pages SIGNATURES After reasonable inquiry and to the best of its knowledge and belief, the undersigned certifies that the information with respect to it set forth in this statement is true, complete, and correct. Dated: July 9, 2003 MILLENNIUM PARTNERS, L.P. By: /s/ Robert Williams ------------------------------ Name: Robert Williams Title: Chief Financial Officer