SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULES 13D-1 (b)(c), AND (d)
AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)
(Amendment No. 4 )*
AVANT IMMUNOTHERAPEUTICS, INC.
- --------------------------------------------------------------------------------
(Name of Issuer)
Common Stock, $.001 par value
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(Title of Class of Securities)
053491106
---------------------------
(CUSIP Number)
* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
Page 1 of 17 Pages
CUSIP No. 053491106 13G Page 2 of 19 Pages
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1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
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5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 127,395
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
127,395
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
127,395
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
.23%
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12 TYPE OF REPORTING PERSON*
PN
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*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 3 of 19 Pages
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners II, L.P.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 127,395
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
127,395
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
127,395
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
.23%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
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*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 4 of 19 Pages
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures III, L.P.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,046,908
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,046,908
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,046,908
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
3.72%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 5 of 19 Pages
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,046,908
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,046,908
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,046,908
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
3.72%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 6 of 19 Pages
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
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3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 601,099
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
601,099
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
601,099
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
1.09%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 7 of 19 Pages
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 601,099
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
601,099
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
601,099
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
1.09%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 8 of 19 Pages
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1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
James H. Cavanaugh, Ph.D.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,775,402
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,775,402
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,775,402
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
5.04%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 9 of 19 Pages
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1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Harold R. Werner
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,775,402
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,775,402
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,775,402
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
5.04%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 10 of 19 Pages
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1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
William Crouse
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
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3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,775,402
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,775,402
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,775,402
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
5.04%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
CUSIP No. 053491106 13G Page 11 of 19 Pages
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
John W. Littlechild
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
--------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,775,402
OWNED BY --------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON
WITH --------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,775,402
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,775,402
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
5.04%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
Page 12 of 19 pages
Item 1.
(a) Name of Issuer:
Avant Immunotherapeutics, Inc.
(b) Address of Issuer's Principal Executive Offices:
119 Fourth Avenue
Needham, Massachusetts 02494-2725
Item 2.
(a) Name of Person Filing:
HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners II,
L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV III"),
HealthCare Partners III, L.P. ("HCP III"), HealthCare Ventures IV,
L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"), Dr.
Cavanaugh and Messrs. Werner, Littlechild and Crouse(1). See
attached Exhibit A which is a copy of their agreement in writing to
file this statement on behalf of each of them.
(b) Address of Principal Business Office or, if none, Residence:
The business address for HCV II, HCP II, HCV III, HCP III, HCV IV,
HCP IV and Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau
Street, Princeton, New Jersey 08542. The business address for Messr.
Littlechild is One Kendall Square, Building 300, Cambridge,
Massachusetts 02139.
(c) Citizenship:
HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are limited
partnerships organized under the laws of the State of Delaware. Dr.
Cavanaugh and Messrs. Werner, Littlechild, and Crouse are each
United States citizens.
- --------
(1) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general
partners of HCP II, HCP III and HCP IV, which are the general
partners of HCV II, HCV III and HCV IV, respectively, the record
holders of shares of the Issuer's securities reported hereto.
Page 13 of 19 pages
(d) Title of Class of Securities:
Common Stock, par value $.001 (the "Shares").
(e) CUSIP Number:
053491106
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b),
check whether the person filing is a:
Inapplicable.
Item 4. Ownership.
(a) Amount Beneficially Owned:
As of December 31, 2000: HCV II and HCP II beneficially owned
127,395 Shares, all of which are immediately exercisable warrants to
purchase the same number of Shares of the Issuer's Common Stock; HCV
III and HCP III beneficially owned 2,046,908 Shares, consisting of
1,753,971 Shares of the Issuer's Common Stock and immediately
exercisable warrants to purchase 292,937 Shares of the Issuer's
Common Stock; HCV IV and HCP IV beneficially owned 601,099 Shares,
consisting of 515,074 Shares of the Issuer's Common Stock and
immediately exercisable warrants to purchase 86,025 Shares of the
Issuer's Common Stock; Dr. Cavanaugh and Messrs. Werner, Littlechild
and Crouse beneficially owned 2,775,402 Shares, consisting of
2,269,045 Shares of the Issuer's Common Stock and immediately
exercisable warrants to purchase 506,357 Shares of the Issuer's
Common Stock.
(b) Percent of Class:
As of December 31, 2000: the 127,395 immediately exercisable
warrants to purchase the same number of Shares of the Issuer's
Common Stock beneficially owned by HCV II and HCP II constitute .23%
of Issuer's Shares outstanding; the 2,046,908 Shares, which includes
the warrants to purchase the Shares of the Issuer's Common Stock,
beneficially owned by HCV III and HCP III constitute 3.72% of the
Issuer's Shares outstanding; the 601,099 Shares, which includes the
warrants to purchase the Shares of the Issuer's Common Stock,
beneficially owned by HCV IV and HCP IV constitute 1.09% of the
Issuer's Shares outstanding; the 2,775,402 Shares, which includes
the warrants to purchase the Shares of the Issuer's Common Stock,
beneficially owned by Dr. Cavanaugh and Messrs. Werner, Littlechild
and Crouse constitute 5.04% of the Issuer's Shares outstanding.
Page 14 of 19 pages
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Not applicable.
(ii) shared power to vote or to direct the vote:
HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild,
and Crouse share the power to vote or direct the vote of those
Shares owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild, and Crouse share the power to vote or direct the
vote of those Shares owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild,
and Crouse share the power to vote or direct the vote of those
Shares owned by HCV IV.
(iii) sole power to dispose or to direct the disposition of:
Not applicable.
(iv) shared power to dispose of or to direct the disposition of:
HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner and
Littlechild share the power to dispose of or direct the
disposition of those Shares owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to dispose of or direct
the disposition of those Shares owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild
and Crouse share the power to dispose of or direct the
disposition of those Shares owned by HCV IV.
Item 5. Ownership of Five Percent or less of a Class:
Inapplicable.
Page 15 of 19 pages
Item 6. Ownership of More than Five Percent on Behalf of Another Person:
Inapplicable.
Item 7. Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on by the Parent Holding Company:
Inapplicable.
Item 8. Identification and Classification of Members of the Group:
Inapplicable.
Item 9. Notice of Dissolution of Group:
Inapplicable.
Item 10. Certification:
Inapplicable.
Page 16 of 19 pages
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.
Dated: February 2, 2001 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P.
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P.
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P.
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey ---------------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey ---------------------------------------
Harold R. Werner
Page 17 of 19 pages
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts ---------------------------------------
John W. Littlechild
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey ---------------------------------------
William Crouse
Page 18 of 19 pages
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of Avant
Immunotherapeutics, Inc. and hereby affirm that such Schedule 13G is being filed
on behalf of each of the undersigned.
Dated: February 2, 2001 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners II, L.P.
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners III, L.P.
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners IV, L.P.
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Dated: February 2, 2001 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
---------------------------------------
Administrative Partner
Page 19 of 19 pages
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey ---------------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey ---------------------------------------
Harold R. Werner
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts ---------------------------------------
John W. Littlechild
Dated: February 2, 2001 By: /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey ---------------------------------------
William Crouse